ZFIN ID: ZDB-LAB-201229-1
Henke Lab
PI/Director: Henke, Katrin
Contact Person: Henke, Katrin
Email: khenke@emory.edu
URL: http://henkelab.com
Address: Emory University School of Medicine Orthopaedics Department 615 Michael St Whitehead Biomed Res Bldg, Rm 605F Atlanta, GA 30322
Country: United States
Phone: 404-727-7425
Line Designation: em


Our lab explores gene function during development, homeostasis and disease of the musculoskeletal system utilizing the zebrafish as a model. Zebrafish are widely used in biomedical research due to ease of genetic manipulation, high fecundity, external fertilization, rapid early development and transparency of early life stages. They show strong similarities with human physiology and in genetic architecture. While at first glance the skeleton of the zebrafish looks very different compared to a human skeleton, it contains the same major cell types and shows a strong correlation in its structure and genetic regulation. Taking advantage of the many imaging, genetic and genomic tools in zebrafish and the diverse expertise in the Orthopaedics Department, we seek to gain crucial insight into musculoskeletal biology, disease etiology and progression to aid in the development of new treatments and therapeutic strategies.


Peskin, B., Henke, K., Cumplido, N., Treaster, S., Harris, M.P., Bagnat, M., Arratia, G. (2020) Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. Current biology : CB. 30(14):2805-2814.e3
Rose, C.D., Pompili, D., Henke, K., Van Gennip, J.L.M., Meyer-Miner, A., Rana, R., Gobron, S., Harris, M.P., Nitz, M., Ciruna, B. (2020) SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. Current biology : CB. 30(12):2363-2373.e6
Coulter, M.E., Musaev, D., DeGennaro, E.M., Zhang, X., Henke, K., James, K.N., Smith, R.S., Hill, R.S., Partlow, J.N., Muna Al-Saffar, ., Kamumbu, A.S., Hatem, N., Barkovich, A.J., Aziza, J., Chassaing, N., Zaki, M.S., Sultan, T., Burglen, L., Rajab, A., Al-Gazali, L., Mochida, G.H., Harris, M.P., Gleeson, J.G., Walsh, C.A. (2020) Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival. Genetics in medicine : official journal of the American College of Medical Genetics. 22(6):1040-1050
Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
Caetano-Lopes, J., Henke, K., Urso, K., Duryea, J., Charles, J.F., Warman, M.L., Harris, M.P. (2020) Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development (Cambridge, England). 147(2):
Urso, K., Caetano-Lopes, J., Lee, P.Y., Yan, J., Henke, K., Sury, M., Liu, H., Zgoda, M., Jacome-Galarza, C., Nigrovic, P.A., Duryea, J., Harris, M.P., Charles, J.F. (2019) A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Bone. 127:104-113
Villani, A., Benjaminsen, J., Moritz, C., Henke, K., Hartmann, J., Norlin, N., Richter, K., Schieber, N.L., Franke, T., Schwab, Y., Peri, F. (2019) Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. Developmental Cell. 49(1):77-88.e7
Webster, K.A., Henke, K., Ingalls, D.M., Nahrin, A., Harris, M.P., Siegfried, K.R. (2019) Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germ line of zebrafish. Reproduction (Cambridge, England). 157(4):383-398
Gistelinck, C., Kwon, R.Y., Malfait, F., Symoens, S., Harris, M.P., Henke, K., Hawkins, M.B., Fisher, S., Sips, P., Guillemyn, B., Bek, J.W., Vermassen, P., De Saffel, H., Witten, P.E., Weis, M., De Paepe, A., Eyre, D.R., Willaert, A., Coucke, P.J. (2018) Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Proceedings of the National Academy of Sciences of the United States of America. 115(34):E8037-E8046
Henke, K., Daane, J.M., Hawkins, M.B., Dooley, C.M., Busch-Nentwich, E.M., Stemple, D.L., Harris, M.P. (2017) Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form.. Genetics. 207(2):609-623
Charles, J.F., Sury, M., Tsang, K., Urso, K., Henke, K., Huang, Y., Russell, R., Duryea, J., Harris, M.P. (2017) Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis. Bone. 101:162-171
Rossi, F., Casano, A.M., Henke, K., Richter, K., Peri, F. (2015) The SLC7A7 Transporter Identifies Microglial Precursors prior to Entry into the Brain. Cell Reports. 11(7):1008-17
Hu, W.F., Pomp, O., Ben-Omran, T., Kodani, A., Henke, K., Mochida, G.H., Yu, T.W., Woodworth, M.B., Bonnard, C., Raj, G.S., Tan, T.T., Hamamy, H., Masri, A., Shboul, M., Al Saffar, M., Partlow, J.N., Al-Dosari, M., Alazami, A., Alowain, M., Alkuraya, F.S., Reiter, J.F., Harris, M.P., Reversade, B., Walsh, C.A. (2014) Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number. Neuron. 84:1240-1257
Henke, K., Bowen, M.E., and Harris, M.P. (2013) Identification of mutations in zebrafish using next-generation sequencing. Current Protocols in Moledular Biology. 104:Unit 7.13
Henke, K., Bowen, M.E., and Harris, M.P. (2013) Perspectives for identification of mutations in the zebrafish: Making use of next-generation sequencing technologies for forward genetic approaches. Methods (San Diego, Calif.). 62(3):185-96
Dauber, A., Lafranchi, S.H., Maliga, Z., Lui, J.C., Moon, J.E., McDeed, C., Henke, K., Zonana, J., Kingman, G.A., Pers, T.H., Baron, J., Rosenfeld, R.G., Hirschhorn, J.N., Harris, M.P., and Hwa, V. (2012) Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein. The Journal of clinical endocrinology and metabolism. 97(11):E2140-2151
Bowen, M.E., Henke, K., Siegfried, K.R., Warman, M.L., and Harris, M.P. (2012) Efficient Mapping and Cloning of Mutations in Zebrafish by Low-Coverage Whole-Genome Sequencing. Genetics. 190(3):1017-1024