ZFIN ID: ZDB-LAB-200124-2
McLean Lab
PI/Director: McLean, David
Contact Person: McLean, David
Email: david-mclean@northwestern.edu
URL: http://www.neurobiology.northwestern.edu/people/core-faculty/david-mclean.html
Address: Cook Hall (Room 2103) 2205 Tech Drive Northwestern University Evanston, IL 60208
Country: United States
Phone: 847.467.1696
Fax: 847.491.5211
Line Designation: k


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 7 genomic features


STATEMENT OF RESEARCH INTERESTS
We are interested in the development and functional organization of neuronal networks that control innate motor behaviors. Specifically, we study motor circuits controlling exploratory and evasive maneuvers in developing zebrafish and how excitatory and inhibitory circuits in the brainstem and spinal cord control the speed and direction of locomotion. To do so, the lab uses a combination of molecular, imaging, electrophysiology and behavioral approaches.


LAB MEMBERS
Chiu, Cindy Post-Doc Jay, Michael Post-Doc Kishore, Sandeep Post-Doc
Agha, Moneeza Graduate Student Gocker, Rachel Fish Facility Staff Szuter, Elissa


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Najac, M., McLean, D.L., Raman, I.M. (2023) Synaptic variance and action potential firing of cerebellar output neurons during motor learning in larval zebrafish. Current biology : CB. 33(16):3299-3311.e3
Jay, M., MacIver, M.A., McLean, D.L. (2023) Spinal basis of direction control during locomotion in larval zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 43(22):4062-4074
Menelaou, E., Kishore, S., McLean, D.L. (2022) Mixed synapses reconcile violations of the size principle in zebrafish spinal cord. eLIFE. 11:
Bhattacharyya, K., McLean, D.L., MacIver, M.A. (2021) Intersection of motor volumes predicts the outcome of ambush predation of larval zebrafish. The Journal of experimental biology. 224(Pt 5):
Kishore, S., Cadoff, E.B., Agha, M.A., McLean, D.L. (2020) Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord. Science (New York, N.Y.). 370:431-436
Harmon, T.C., McLean, D.L., Raman, I.M. (2020) Integration of swimming-related synaptic excitation and inhibition by olig2+ eurydendroid neurons in larval zebrafish cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(15):3063-3074
Bello-Rojas, S., Istrate, A.E., Kishore, S., McLean, D.L. (2019) Central and peripheral innervation patterns of defined axial motor units in larval zebrafish. The Journal of comparative neurology. 527(15):2557-2572
Kumar, M., Kishore, S., Nasenbeny, J., McLean, D.L., Kozorovitskiy, Y. (2018) Integrated one- and two-photon scanned oblique plane illumination (SOPi) microscopy for rapid volumetric imaging. Optics express. 26:13027-13041