ZFIN ID: ZDB-LAB-190627-1
Quinn Lab
PI/Director: Quinn, Alex
Contact Person: Quinn, Alex
Email: alex.quinn@dal.ca
URL: http://medicine.dal.ca/departments/department-sites/physiology/our-people/our-faculty/alexander-quinn.html
Address: 5850 College St, Lab 4J Halifax, NS B3H 4R2
Country: Canada
Phone: 902-494-4349
Fax: 902-494-1685
Line Designation: hsi


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 1 genomic features


STATEMENT OF RESEARCH INTERESTS
The Cardiac Autoregulation and Arrhythmias Laboratory, directed by Dr. Alex Quinn, is focused on the intrinsic regulation of cardiac function and the effects of mechano-electric interactions on heart rhythm. We employ a multi-scale, multi-species approach (from whole animals to isolated tissue and cell preparations, including rabbit, mouse, and zebrafish), combining engineering-based experimental methods (optical mapping, fluorescence microscopy, and optogenetics) with computational modeling to gain insight into normal cardiovascular function and pathologies at various levels of functional and structural complexity. Our overall goals are to: (i) define organ-, tissue-, cell-, and subcellular-level mechanisms responsible for (patho-)physiological responses; (ii) discover their relevance for heart rhythm in health and disease; and (iii) use this knowledge to develop novel targeted anti-arrhythmic therapies.


LAB MEMBERS
Stoyek, Matthew Post-Doc Baillie, Jonathan Graduate Student Cameron, Breanne Graduate Student
MacDonald, Eilidh Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Kopton, R.A., Baillie, J.S., Rafferty, S.A., Moss, R., Zgierski-Johnston, C.M., Prykhozhij, S.V., Stoyek, M.R., Smith, F.M., Kohl, P., Quinn, T.A., Schneider-Warme, F. (2018) Cardiac Electrophysiological Effects of Light-Activated Chloride Channels. Frontiers in Physiology. 9:1806
Stoyek, M.R., Rog-Zielinska, E.A., Quinn, T.A. (2018) Age-associated changes in electrical function of the zebrafish heart. Progress in Biophysics and Molecular Biology. 138:91-104
MacDonald, E.A., Stoyek, M.R., Rose, R.A., Quinn, T.A. (2017) Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemaking. Progress in Biophysics and Molecular Biology. 130(Pt B):198-211
Stoyek, M.R., Quinn, T.A., Croll, R.P., Smith, F.M. (2016) Zebrafish heart as a model to study the integrative autonomic control of pacemaker function. American journal of physiology. Heart and circulatory physiology. 311(3):H676-88