ZFIN ID: ZDB-LAB-190408-1
Longhou Fang Lab
PI/Director: Fang, Longhou
Contact Person: Yan, Qing
Email: qyan@houstonmethodist.org
URL: http://openwetware.org/wiki/Fanglab:people
Address: 6670 Bertner Ave. RIB10-430.19, Houston Tx 77030
Country: United States
Phone: 713-441-7206
Fax: 713-363-9782
Line Designation: hmr

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The Fang lab employ zebrafish and mouse models to studying lipid metabolism in angiogenesis, lymphangiogenesis, and hematopoiesis. During his postdoctoral studies at UC San Diego, Dr. Fang discovered that apolipoprotein (apoA-I) binding protein (AIBP) controls angiogenesis via regulation of cholesterol homeostasis. Based upon the findings, the Fang laboratory will be focusing on the role of AIBP-regulated lipid metabolism in endothelial cell biology. We will use a plethora of developmental and disease models such as zebrafish angiogenesis, murine angiogenesis, heart hypertrophy, heart ischemia and reperfusion, peripheral artery ischemia and reperfusion, corneal angiogenesis, and tumorigenesis in mice.

Gu, Qilin Post-Doc Yang, Xiaojie Post-Doc Sun, Quan Research Staff
Yan, Qing Research Staff Kim, Jun-Dae

Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366
Yang, X., Li, X., Gu, Q., Li, Q., Cui, Z. (2019) Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish. Cells. 8(9):
Fang, L., Miller, Y.I. (2019) Regulation of lipid rafts, angiogenesis and inflammation by AIBP. Current opinion in lipidology. 30(3):218-223
Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J.D., Wang, R., Xiong, F., Meng, S., Clements, T.P., Tandon, B., Wagner, D.S., Diaz, M.F., Wenzel, P.L., Miller, Y.I., Traver, D., Cooke, J.P., Li, W., Zon, L.I., Chen, K., Bai, Y., Fang, L. (2019) AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science (New York, N.Y.). 363:1085-1088
Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2019) Publisher Correction: Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 9:4152
Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2018) Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 8:9840
Meng, S., Gu, Q., Yang, X., Lv, J., Owusu, I., Matrone, G., Chen, K., Cooke, J.P., Fang, L. (2018) TBX20 Regulates Angiogenesis Through the PROK2-PROKR1 Pathway. Circulation. 138(9):913-928
Matrone, G., Meng, S., Gu, Q., Lv, J., Fang, L., Chen, K., Cooke, J.P. (2017) Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(10):1860-1868
Hwangbo, C., Lee, H.W., Kang, H., Ju, H., Wiley, D.S., Papangeli, I., Han, J., Kim, J.D., Dunworth, W.P., Hu, X., Lee, S., El-Hely, O., Sofer, A., Pak, B., Peterson, L., Comhair, S., Hwang, E.M., Park, J.Y., Thomas, J.L., Bautch, V.L., Erzurum, S.C., Chun, H.J., Jin, S.W. (2017) Modulation of Endothelial BMPR2 Activity by VEGFR3 in Pulmonary Arterial Hypertension. Circulation. 135(23):2288-2298
Meng, S., Mao, R., Gu, Q., Araujo-Gutierrez, R., Kumar, S., Yan, Q., Almazan, F., Youker, K.A., Fu, Y., Pownall, H.J., Cooke, J.P., Miller, Y.I., Fang, L. (2017) AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling. Circulation research. 120(11):1727-1739
Mouillesseaux, K.P., Wiley, D.S., Saunders, L.M., Wylie, L.A., Kushner, E.J., Chong, D.C., Citrin, K.M., Barber, A.T., Park, Y., Kim, J.D., Samsa, L.A., Kim, J., Liu, J., Jin, S.W., Bautch, V.L. (2016) Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6.. Nature communications. 7:13247
Koun, S., Kim, J.D., Rhee, M., Kim, M.J., Huh, T.L. (2016) Spatiotemporal expression pattern of the zebrafish aquaporin 8 family during early developmental stages. Gene expression patterns : GEP. 21(1):1-6
Yang, X., Gu, Q., Lin, L., Li, S., Zhong, S., Li, Q., Cui, Z. (2015) Nucleoporin 62-like protein activates canonical Wnt signaling through facilitating the nuclear import of β-catenin in zebrafish. Molecular and cellular biology. 35(7):1110-24
Gu, Q., Yang, X., Lin, L., Li, S., Li, Q., Zhong, S., Peng, J., Cui, Z. (2014) Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Hepatology (Baltimore, Md.). 60(6):1929-41
Zhong, L., Yuan, L., Rao, Y., Li, Z., Gu, Q., Long, Y., Zhang, X., Cui, Z., Xu, Y., Dai, H. (2014) Investigation of effect of 17α-ethinylestradiol on vigilin expression using an isolated recombinant antibody. Aquatic toxicology (Amsterdam, Netherlands). 156:1-9
So, J.H., Kim, J.D., Yoo, K.W., Kim, H.T., Jung, S.H., Choi, J.H., Lee, M.S., Jin, S.W., Kim, C.H. (2014) FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential Anti-Angiogenic Factor during Zebrafish Vascular Development. PLoS One. 9:e109517
Kim, J.D., Lee, H.W., Jin, S.W. (2014) Diversity Is in My Veins: Role of Bone Morphogenetic Protein Signaling During Venous Morphogenesis in Zebrafish Illustrates the Heterogeneity Within Endothelial Cells. Arterioscler. Thromb. Vasc. Biol.. 34(9):1838-45
Kim, J.D., Jin, S.W. (2014) A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies. Molecules and cells. 37(7):503-10
Kim, J.D., Kim, H.J., Koun, S., Ham, H.J., Kim, M.J., Rhee, M., Huh, T.L. (2014) Zebrafish Crip2 Plays a Critical Role in Atrioventricular Valve Development by Downregulating the Expression of ECM Genes in the Endocardial Cushion. Molecules and cells. 37(5):406-11
Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E., and Yin, Z. (2014) Sept6 Is Required for Ciliogenesis in Kupffer's Vesicle, the Pronephros, and the Neural Tube during Early Embryonic Development. Molecular and cellular biology. 34(7):1310-1321
Kim, J.D., Kim, J. (2014) Alk3/Alk3b and Smad5 Mediate BMP Signaling during Lymphatic Development in Zebrafish. Molecules and cells. 37:270-4
Kim, J.D., Kang, Y., Kim, J., Papangeli, I., Kang, H., Wu, J., Park, H., Nadelmann, E., Rockson, S.G., Chun, H.J., and Jin, S.W. (2014) Essential role of apelin signaling during lymphatic development in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 34(2):338-345
Dunworth, W.P., Cardona-Costa, J., Cagavi, E., Kim, J.D., Fischer, J.C., Meadows, S., Wang, Y., Cleaver, O., Qyang, Y., Ober, E.A., and Jin, S.W. (2014) Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circulation research. 114(1):56-66
Nie, L., Guo, X., Esmailzadeh, L., Zhang, J., Asadi, A., Collinge, M., Li, X., Kim, J.D., Woolls, M., Jin, S.W., Dubrac, A., Eichmann, A., Simons, M., Bender, J.R., and Sadeghi, M.M. (2013) Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J. Clin. Invest.. 123(12):5082-97
Gu, Q., Yang, X., He, X., Li, Q., and Cui, Z. (2013) Generation and characterization of a transgenic zebrafish expressing the reverse tetracycline transactivator. Journal of genetics and genomics = Yi chuan xue bao. 40(10):523-531
Kim, J.D., Kang, H., Larrivée, B., Lee, M.Y., Mettlen, M., Schmid, S.L., Roman, B.L., Qyang, Y., Eichmann, A., and Jin, S.W. (2012) Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Developmental Cell. 23(2):441-448
Kim, Y.S., Kim, M.J., Koo, T.H., Kim, J.D., Koun, S., Ham, H.J., Lee, Y.M., Rhee, M., Yeo, S.Y., and Huh, T.L. (2012) Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. Biochemical and Biophysical Research Communications. 423(1):140-146
Kim, S., Kim, J.D., Chung, A.Y., Kim, H.S., Kim, Y.S., Kim, M.J., Koun, S., Lee, Y.M., Rhee, M., Park, H.C., and Huh, T.L. (2012) Antagonistic Regulation of PAF1C and p-TEFb Is Required for Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(24):8201-8207
Wiley, D.M., Kim, J.D., Hao, J., Hong, C.C., Bautch, V.L., and Jin, S.W. (2011) Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nature cell biology. 13(6):686-92
Park, J.S., Kim, H.S., Kim, J.D., Seo, J., Chung, K.S., Lee, H.S., Huh, T.L., Jo, I., and Kim, Y.O. (2009) Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development. Developmental dynamics : an official publication of the American Association of Anatomists. 238(6):1574-1581