ZFIN ID: ZDB-LAB-180424-2
Huveneers Lab
PI/Director: Huveneers, Stephan
Contact Person: Huveneers, Stephan
Email: s.huveneers@amc.uva.nl
URL: http://www.huveneerslab.eu
Address: Academic Medical Center – University of Amsterdam Vascular Microenvironment & Integrity Lab Dept. Medical Biochemistry Meibergdreef 9, Room K1-116 1105 AZ Amsterdam
Country: Netherlands
Phone: +31 20 5665154
Fax:
Line Designation: ams


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Our research is focused on the molecular understanding of vascular remodeling through cell adhesion structures. An important aspect of adhesion regulation occurs via mechanotransduction pathways at integrin and cadherin-based adhesion complexes. We currently study the physiological importance of endothelial junctional events, such as Pacsin2 and Vinculin recruitment, by combining high resolution microscopy of in vitro junction dynamics with visualizing endothelial interactions in transgenic zebrafish.


LAB MEMBERS
van der Stoel, Miesje Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
van der Stoel, M.M., Kotini, M.P., Schoon, R.M., Affolter, M., Belting, H.G., Huveneers, S. (2022) Vinculin strengthens the endothelial barrier during vascular development. Vascular biology (Bristol, England). 5(1)
Kotini, M.P., van der Stoel, M.M., Yin, J., Han, M.K., Kirchmaier, B., de Rooij, J., Affolter, M., Huveneers, S., Belting, H.G. (2022) Vinculin controls endothelial cell junction dynamics during vascular lumen formation. Cell Reports. 39:110658
Angulo-Urarte, A., Casado, P., Castillo, S.D., Kobialka, P., Kotini, M.P., Figueiredo, A.M., Castel, P., Rajeeve, V., Milà-Guasch, M., Millan, J., Wiesner, C., Serra, H., Muixi, L., Casanovas, O., Viñals, F., Affolter, M., Gerhardt, H., Huveneers, S., Belting, H.G., Cutillas, P.R., Graupera, M. (2018) Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility. Nature communications. 9:4826
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