ZFIN ID: ZDB-LAB-170302-3
Roger Chung Lab
PI/Director: Chung, Roger
Co-PI / Senior
Researcher:
Morsch, Marco
Contact Person: Chung, Roger
Email: roger.chung@mq.edu.au
URL: http://www.mq.edu.au/about/about-the-university/faculties-and-departments/faculty-of-medicine-and-health-sciences/staff-profiles/roger-chung
Address: Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, 2 Technology Place, Macquarie University, NSW 2109, Australia
Country: Australia
Phone: +61 2 9850 2724
Fax: +61 2 9850 3600
Line Designation: mq


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
1. Understanding the role of abnormal protein aggregates in the pathogenesis of MND

2. Using zebrafish to visualise neuron‐glia interactions underlying MND disease mechanisms

3. Nanoparticle‐based theranostics for MND and other neurodegenerative diseases


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Cheng, D., Morsch, M., Shami, G.J., Chung, R.S., Braet, F. (2020) Observation and characterisation of macrophages in zebrafish liver. Micron (Oxford, England : 1993). 132:102851
Aksoy, Y.A., Nguyen, D.T., Chow, S., Chung, R.S., Guillemin, G.J., Cole, N.J., Hesselson, D. (2019) Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos. Communications biology. 2:198
Fu, L., Chung, R., Shi, B. (2019) Upconversion Nanoparticle-Based Strategy for Crossing the Blood-Brain Barrier to Treat the Central Nervous System Disease. Methods in molecular biology (Clifton, N.J.). 2054:263-282
Cheng, D., Morsch, M., Shami, G.J., Chung, R.S., Braet, F. (2018) Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging. Experimental cell research. 374(1):162-171
Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S.S.L., Formella, I., Hortle, E., Yuan, K.C., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2018) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 28(4):698
Formella, I., Svahn, A.J., Radford, R.A.W., Don, E.K., Cole, N.J., Hogan, A., Lee, A., Chung, R.S., Morsch, M. (2018) Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo. Redox Biology. 19:226-234
Svahn, A.J., Don, E.K., Badrock, A.P., Cole, N.J., Graeber, M.B., Yerbury, J.J., Chung, R., Morsch, M. (2018) Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons. Acta Neuropathologica. 136(3):445-459
Gwee, S.S.L., Radford, R.A.W., Chow, S., Syal, M.D., Morsch, M., Formella, I., Lee, A., Don, E.K., Badrock, A.P., Cole, N.J., West, A.K., Cheung, S.N.S., Chung, R.S. (2018) Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish. Cellular and molecular life sciences : CMLS. 75(23):4269-4285
Fu, L., Morsch, M., Shi, B., Wang, G., Lee, A., Radford, R., Lu, Y., Jin, D., Chung, R. (2017) A versatile upconversion surface evaluation platform for bio-nano surface selection for the nervous system. Nanoscale. 9(36):13683-13692
Chen, L., Watson, C., Morsch, M., Cole, N.J., Chung, R.S., Saunders, D.N., Yerbury, J.J., Vine, K.L. (2017) Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles. Frontiers in neuroscience. 11:476
Lee, A., Rayner, S.L., Gwee, S.S.L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A.K., Don, E.K., Cole, N.J., Yang, S., Williams, K.L., Yerbury, J.J., Blair, I.P., Atkin, J.D., Molloy, M.P., Chung, R.S. (2017) Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.. Cellular and molecular life sciences : CMLS. 75(2):335-354
Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S., Formella, I., Hortle, E., Yuan, K., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2017) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 26(14):2616-2626
Morsch, M., Radford, R.A., Don, E.K., Lee, A., Hortle, E., Cole, N.J., Chung, R.S. (2017) Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy. Journal of visualized experiments : JoVE. (120)
Cheng, D., Shami, G., Morsch, M., Huynh, M., Trimby, P., Braet, F. (2017) Relocation is the key to successful correlative fluorescence and scanning electron microscopy. Methods in cell biology. 140:215-244
Morsch, M., Radford, R., Lee, A., Don, E.K., Badrock, A.P., Hall, T.E., Cole, N.J., Chung, R. (2015) In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord. Frontiers in Cellular Neuroscience. 9:321