ZFIN ID: ZDB-LAB-170302-2
Laboratory of Molecular Medicine
PI/Director: Zhou, Jianfeng
Contact Person: Zhou, Jianfeng
Email: jfzhou@ouc.edu.cn
URL: http://eweb.ouc.edu.cn/mp/4b/13/c3878a19219/page.htm
Address: School of Medicine and Pharmacy Ocean University of China 5 Yushan Road Qingdao 266003 China
Country: China
Phone: 86-532-82032957
Fax: 86-532-82032957
Line Designation: ouc

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Laboratory of Molecular Medicine (LMM) was established in 2005. Research areas in the LMM include 1) basic biology of molecular medicine; 2) roles of biomolecules in regulating development, growth, reproduction, and aging; 3) establishment of animal models of human disease; 4) chemical biology and compound screening by using zebrafish. Research in the LMM is supported by NSFC, MOST and other fundings.

He, Yuxue Graduate Student Li, Mengjiao Graduate Student Wang, Bo Graduate Student
Wang, Caixia Graduate Student Wang, Zhenghua Graduate Student Zhang, Haifeng Graduate Student
Zhao, Qian Graduate Student Liu, Yunzhang Technical Staff Rong, Xiaozhi

Yue, Y., Tang, Y., Huang, H., Zheng, D., Liu, C., Zhang, H., Liu, Y., Li, Y., Sun, X., Lu, L. (2023) VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. The Journal of biological chemistry. 299(6):104829
Wang, C., Zhang, X., Wang, X., Zhai, Y., Li, M., Pan, J., Bai, Y., Rong, X., Zhou, J. (2022) Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development. Journal of Cell Science. 135(21):
Li, X., Zhao, F., Fu, C., Yang, Y., Xu, Q., Hao, Y., Shi, X., Chen, D., Bi, X., Gong, Z., Wu, S., Zhang, H. (2022) Early- and whole-life exposures to florfenicol disrupts lipid metabolism and induces obesogenic effects in zebrafish (Danio rerio). Chemosphere. 308(Pt 3):136429
Xiao, H., Wang, H., He, Q., Zhou, J., Du, S. (2022) Gene expression and functional analysis of Aha1a and Aha1b in stress response in zebrafish. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 262:110777
Sun, C., Liu, Q., Shah, M., Che, Q., Zhang, G., Zhu, T., Zhou, J., Rong, X., Li, D. (2022) Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromyces sp. HDN151403, Inhibits Wnt/β-Catenin Signaling Pathway. Organic letters. 24(22):3993-3997
Li, M., Rong, X., Lu, L., Li, Y., Yao, K., Ge, W., Duan, C. (2021) IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. General and comparative endocrinology. 313:113875
Wang, B., Rong, X., Zhou, Y., Liu, Y., Sun, J., Zhao, B., Deng, B., Lu, L., Lu, L., Li, Y., Zhou, J. (2021) Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development (Cambridge, England). 148(9):
Zhang, H., Rong, X., Wang, C., Liu, Y., Lu, L., Li, Y., Zhao, C., Zhou, J. (2020) VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs. The Journal of biological chemistry. 295(49):16826-16839
Li, J., Zhang, Y., Cai, C., Rong, X., Shao, M., Li, J., Yang, C., Yu, G. (2019) Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma. Biomaterials science. 8(1):189-200
Wang, B., Du, X., Wang, H., Jin, C., Gao, C., Liu, J., Zhang, Q. (2019) Comparative studies on duplicated tdrd7 paralogs in teleosts: Molecular evolution caused neo-functionalization. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 30:347-357
Wang, B., Yang, F., Li, R., Li, X., Wu, X., Sun, Z., Zhai, J., He, Y., Qi, J. (2018) Functional characterization of Cynoglossus semilaevis R-spondin2 and its role in muscle development during embryogenesis. Genes & genetic systems. 93(5):181-190
Bai, Y., Liu, C., Zhou, J., Rong, X., Wang, H. (2018) Molecular, functional, and gene expression analysis of zebrafish Ror1 receptor. Fish physiology and biochemistry. 45(1):355-363
Chen, J.Y., Tan, X., Wang, Z.H., Liu, Y.Z., Zhou, J.F., Rong, X.Z., Lu, L., Li, Y. (2018) The Ribosome Biogenesis Protein Esf1 is Essential for Pharyngeal Cartilage Formation in zebrafish. The FEBS journal. 285(18):3464-3484
Yao, Q., Zhang, P., Lu, L., Liu, Y., Li, Y., Duan, C. (2018) Nuclear localization of Hif-3α requires two redundant NLS motifs in its unique C-terminal region. FEBS letters. 592(16):2769-2775
Zhao, J., Wang, B., Yu, H., Wang, Y., Liu, X., Zhang, Q. (2018) tdrd1 is a germline-specific and sexually dimorphically expressed gene in Paralichthys olivaceus. Gene. 673:61-69
Liu, T., Ning, J., Wang, B., Dong, B., Li, S., Tian, X., Yu, Z., Peng, Y., Wang, C., Zhao, X., Huo, X., Sun, C.P., Cui, J.N., Feng, L., Ma, X. (2018) An activatable near-infrared fluorescent probe for dipeptidyl peptidase IV and its bioimaging applications in living cells and animals. Analytical chemistry. 90(6):3965-3973
Li, P., Wang, B., Cao, D., Liu, Y., Zhang, Q., Wang, X. (2017) Characterization and functional analysis of the Paralichthys olivaceus prdm1 gene promoter. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 212:32-40
Gaoxiang, W., Pan, Z., Xing, C., Zhao, L., Jiaqi, T., Yang, Y., Fang, Y., Zhou, J. (2017) The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis. Cancer biology & therapy. 18(8):584-595
Rong, X., Zhou, Y., Liu, Y., Zhao, B., Wang, B., Wang, C., Gong, X., Tang, P., Lu, L., Li, Y., Zhao, C., Zhou, J. (2017) Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos. Development (Cambridge, England). 144(9):1687-1697
Chen, S., Liu, Y., Rong, X., Li, Y., Zhou, J., Lu, L. (2017) Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish. Frontiers in endocrinology. 8:21
Shi, L., Zhou, J., Wu, J., Cao, J., Shen, Y., Zhou, H., Li, X. (2016) Quinoxalinone (Part II). Discovery of (Z)-3-(2-(pyridin-4-yl)vinyl)quinoxalinone derivates as potent VEGFR-2 kinase inhibitors. Bioorganic & Medicinal Chemistry. 24(8):1840-52
Bai, Y., Tan, X., Zhang, H., Liu, C., Zhao, B., Li, Y., Lu, L., Liu, Y., Zhou, J. (2014) Ror2 Receptor Mediates Wnt11 Signaling and Affects Convergence and Extension Movements in Zebrafish. The Journal of biological chemistry. 289(30):20664-20676
Rong, X., Chen, C., Zhou, P., Zhou, Y., Li, Y., Lu, L., Liu, Y., Zhou, J., Duan, C. (2014) R-Spondin 3 Regulates Dorsoventral and Anteroposterior Patterning by Antagonizing Wnt/β-Catenin Signaling in Zebrafish Embryos. PLoS One. 9(6):e99514
Liu, C., Luan, J., Bai, Y., Li, Y., Lu, L., Liu, Y., Hakuno, F., Takahashi, S., Duan, C., and Zhou, J. (2014) Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos. General and comparative endocrinology. 197:82-91
Zhou, J., Xiang, J., Zhang, S., and Duan, C. (2013) Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions. Endocrinology. 154(10):3753-63
Kjaer-Sorensen, K., Engholm, D.H., Kamei, H., Morch, M.G., Kristensen, A.O., Zhou, J., Conover, C.A., Duan, C., and Oxvig, C. (2013) Pregnancy-associated plasma protein-A (PAPP-A) modulates early developmental rate in zebrafish independent of its proteolytic activity. The Journal of biological chemistry. 288(14):9982-92
Jiao, S., Ren, H., Li, Y., Zhou, J., Duan, C., Lu, L. (2013) Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells.. Molecular and cellular biochemistry. 373(1):107-113
Zhang, P., Lu, L., Yao, Q., Li, Y., Zhou, J., Liu, Y., and Duan, C. (2012) Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α. American journal of physiology. Regulatory, integrative and comparative physiology. 303(11):R1165-R1174
Zhang, C., Lu, L., Li, Y., Wang, X., Zhou, J., Liu, Y., Fu, P., Gallicchio, M.A., Bach, L.A., and Duan, C. (2012) IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. International Journal of Cancer. 30(9):2003-2012
Feng, Q., Zou, X., Lu, L., Li, Y., Liu, Y., Zhou, J., and Duan, C. (2012) The Stress-Response Gene redd1 Regulates Dorsoventral Patterning by Antagonizing Wnt/β-catenin Activity in Zebrafish. PLoS One. 7(12):e52674
Zhong, Y., Lu, L., Zhou, J., Li, Y., Liu, Y., Clemmons, D.R., and Duan, C. (2011) IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. Journal of Cell Science. 124(11):1925-1935
Jiao, S., Dai, W., Lu, L., Liu, Y., Zhou, J., Li, Y., Korzh, V., and Duan, C. (2011) The Conserved Clusterin Gene Is Expressed in the Developing Choroid Plexus Under the Regulation of Notch But Not IGF Signaling in Zebrafish. Endocrinology. 152(5):1860-1871
Zhou, J., Li, W., Kamei, H., and Duan, C. (2008) Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. PLoS One. 3(12):e3926