ZFIN ID: ZDB-LAB-170302-2
Laboratory of Molecular Medicine
PI/Director: Zhou, Jianfeng
Contact Person: Zhou, Jianfeng
Email: jfzhou@ouc.edu.cn
URL: http://eweb.ouc.edu.cn/mp/4b/13/c3878a19219/page.htm
Address: School of Medicine and Pharmacy Ocean University of China 5 Yushan Road Qingdao 266003 China
Country: China
Phone: 86-532-82032957
Fax: 86-532-82032957
Line Designation: ouc


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
Laboratory of Molecular Medicine (LMM) was established in 2005. Research areas in the LMM include 1) basic biology of molecular medicine; 2) roles of biomolecules in regulating development, growth, reproduction, and aging; 3) establishment of animal models of human disease; 4) chemical biology and compound screening by using zebrafish. Research in the LMM is supported by NSFC, MOST and other fundings.


LAB MEMBERS
He, Yuxue Graduate Student Li, Mengjiao Graduate Student Wang, Bo Graduate Student
Wang, Caixia Graduate Student Wang, Zhenghua Graduate Student Zhang, Haifeng Graduate Student
Zhao, Qian Graduate Student Liu, Yunzhang Technical Staff Rong, Xiaozhi


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Rong, X., Zhou, Y., Liu, Y., Zhao, B., Wang, B., Wang, C., Gong, X., Tang, P., Lu, L., Li, Y., Zhao, C., Zhou, J. (2017) Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos. Development (Cambridge, England).
Chen, S., Liu, Y., Rong, X., Li, Y., Zhou, J., Lu, L. (2017) Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish. Frontiers in endocrinology. 8:21
Shi, L., Zhou, J., Wu, J., Cao, J., Shen, Y., Zhou, H., Li, X. (2016) Quinoxalinone (Part II). Discovery of (Z)-3-(2-(pyridin-4-yl)vinyl)quinoxalinone derivates as potent VEGFR-2 kinase inhibitors. Bioorganic & Medicinal Chemistry. 24(8):1840-52
Bai, Y., Tan, X., Zhang, H., Liu, C., Zhao, B., Li, Y., Lu, L., Liu, Y., Zhou, J. (2014) Ror2 Receptor Mediates Wnt11 Signaling and Affects Convergence and Extension Movements in Zebrafish. The Journal of biological chemistry. 289(30):20664-20676
Rong, X., Chen, C., Zhou, P., Zhou, Y., Li, Y., Lu, L., Liu, Y., Zhou, J., Duan, C. (2014) R-Spondin 3 Regulates Dorsoventral and Anteroposterior Patterning by Antagonizing Wnt/β-Catenin Signaling in Zebrafish Embryos. PLoS One. 9(6):e99514
Liu, C., Luan, J., Bai, Y., Li, Y., Lu, L., Liu, Y., Hakuno, F., Takahashi, S., Duan, C., and Zhou, J. (2014) Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos. Gen. Comp. Endocrinol.. 197:82-91
Zhou, J., Xiang, J., Zhang, S., and Duan, C. (2013) Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions. Endocrinology. 154(10):3753-63
Kjaer-Sorensen, K., Engholm, D.H., Kamei, H., Morch, M.G., Kristensen, A.O., Zhou, J., Conover, C.A., Duan, C., and Oxvig, C. (2013) Pregnancy-associated plasma protein-A (PAPP-A) modulates early developmental rate in zebrafish independent of its proteolytic activity. The Journal of biological chemistry. 288(14):9982-92
Jiao, S., Ren, H., Li, Y., Zhou, J., Duan, C., Lu, L. (2013) Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells.. Molecular and cellular biochemistry. 373(1):107-113
Feng, Q., Zou, X., Lu, L., Li, Y., Liu, Y., Zhou, J., and Duan, C. (2012) The Stress-Response Gene redd1 Regulates Dorsoventral Patterning by Antagonizing Wnt/beta-catenin Activity in Zebrafish. PLoS One. 7(12):e52674
Zhang, P., Lu, L., Yao, Q., Li, Y., Zhou, J., Liu, Y., and Duan, C. (2012) Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3alpha. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 303(11):R1165-1174
Zhang, C., Lu, L., Li, Y., Wang, X., Zhou, J., Liu, Y., Fu, P., Gallicchio, M.A., Bach, L.A., and Duan, C. (2011) IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. International Journal of Cancer. 30(9):2003-2012
Zhong, Y., Lu, L., Zhou, J., Li, Y., Liu, Y., Clemmons, D.R., and Duan, C. (2011) IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. Journal of Cell Science. 124(11):1925-1935
Jiao, S., Dai, W., Lu, L., Liu, Y., Zhou, J., Li, Y., Korzh, V., and Duan, C. (2011) The Conserved Clusterin Gene Is Expressed in the Developing Choroid Plexus Under the Regulation of Notch But Not IGF Signaling in Zebrafish. Endocrinology. 152(5):1860-1871
Zhou, J., Li, W., Kamei, H., and Duan, C. (2008) Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. PLoS One. 3(12):e3926