ZFIN Lab: Wang GX Lab

ZFIN ID: ZDB-LAB-170214-17

Wang GX Lab

PI/Director:	Wang, Guixue
Co-PI / Senior Researcher:	Qiu, Juhui Wang, Yeqi
Contact Person:	Wang, Guixue
Email:	wanggx@cqu.edu.cn
URL:	http://publab.cqu.edu.cn/index.jsp
Address:	Laboratory for Mechno-Developmental Biology, State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University, 174 Shazhengjie, Shapingba, Chongqing, 400030, China,
Country:	China
Phone:	86-23-65112675
Fax:	86-23-65102507
Line Designation:	cqu

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 11 genomic features

STATEMENT OF RESEARCH INTERESTS

Our research interests are focused on the effects of hemodynamic factors on cardio-cerebral- vascular development, mechanical signal transduction and vascular remodeling using zebrafish model, in vivo investigations on the effects of LDL concentration polarization and hemodynamics on atherosclerotic localization in zebrafish, the roles of blood flow in regulating zebrafish caudal vein plexus angiogenesis by inducing bmp signaling, the roles of BMP3 in integrity of blood brain barrier by promoting pericyte coverage in zebrafish embryos. We are also interested in the mechanisms of lymphatic vessel development, intravascular restenosis and late thrombosis, as well as biocompatibility and toxicity test of biomedical materials using zebrafish model.

LAB MEMBERS

Xie, Xiang Post-Doc	Cui, Yuliang Graduate Student	Huang, Lu Graduate Student
Jin, Xuepu Graduate Student	Lei, Daoxi Graduate Student	Li, Tianhan Graduate Student
Luo, Desha Graduate Student	Wang, Qilong Graduate Student	Wang, Yi Graduate Student
Wen, Lin Graduate Student	Zhou, Tian Graduate Student	Zhang, Xiaojuan Technical Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Zhang, T., Yan, W., Liu, C., Duan, W., Duan, Y., Li, Y., Yu, Q., Sun, Y., Tian, J., Zhou, J., Xia, Z., Wang, G., Xu, S. (2023) Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish. Ecotoxicology and environmental safety. 263:115241115241

Wen, L., Yan, W., Zhu, L., Tang, C., Wang, G. (2023) The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis. Cellular and molecular life sciences : CMLS. 80:162162

Yan, Y., Liang, S., Zhang, T., Deng, C., Li, H., Zhang, D., Lei, D., Wang, G. (2023) Acute exposure of Isopyrazam damages the developed cardiovascular system of zebrafish (Danio rerio). Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 58(4):367-377

Cui, Y., Shi, W., Zhang, K., Hou, Z., Wang, Y., Yan, W., Ma, Q., He, S., Huang, J., Lu, C., Wang, Y., Wang, G., Qiu, J. (2022) Temporal-spatial low shear stress induces heterogenous distribution of hematopoietic stem cell budding in zebrafish. Cellular and molecular life sciences : CMLS. 79:399

Chen, G., Wang, M., Zhu, P., Wang, G., Hu, T. (2022) Adverse effects of SYP-3343 on zebrafish development via ROS-mediated mitochondrial dysfunction. Journal of hazardous materials. 437:129382

Liu, B., Yan, W., Luo, L., Wu, S., Wang, Y., Zhong, Y., Tang, D., Maruf, A., Yan, M., Zhang, K., Qin, X., Qu, K., Wu, W., Wang, G. (2021) Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia. Journal of nanobiotechnology. 19:374

Yu, L., He, M., Liu, S., Dou, X., Li, L., Gu, N., Li, B., Liu, Z., Wang, G., Fan, J. (2021) Fluorescent Egg White-Based Carbon Dots as a High-Sensitivity Iron Chelator for the Therapy of Nonalcoholic Fatty Liver Disease by Iron Overload in Zebrafish. ACS applied materials & interfaces. 13(46):54677-54689

Qin, X., Zhang, K., Qiu, J., Wang, N., Qu, K., Cui, Y., Huang, J., Luo, L., Zhong, Y., Tian, T., Wu, W., Wang, Y., Wang, G. (2021) Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress. Bioactive materials. 9:397-410

Lei, D., Zhang, X., Rouf, M.A., Mahendra, Y., Wen, L., Li, Y., Zhang, X., Li, L., Wang, L., Zhang, T., Wang, G., Wang, Y. (2021) Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish. iScience. 24:103386

Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054

Wen, L., Zhang, T., Wang, J., Jin, X., Rouf, M.A., Luo, D., Zhu, Y., Lei, D., Gregersen, H., Wang, Y., Wang, G. (2021) The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics. PLoS Genetics. 17:e1009690

Zhong, Y., Qin, X., Wang, Y., Qu, K., Luo, L., Zhang, K., Liu, B., Obaid, E.A.M.S., Wu, W., Wang, G. (2021) "Plug and Play" Functionalized Erythrocyte Nanoplatform for Target Atherosclerosis Management. ACS applied materials & interfaces. 13:33862-33873

Wang, Q., Chen, G., Zhang, Q., Wang, M., Wang, G., Hu, T. (2021) Microcystin-leucine arginine blocks vasculogenesis and angiogenesis through impairing cytoskeleton and impeding endothelial cell migration by downregulating integrin-mediated Rho/ROCK signaling pathway. Environmental science and pollution research international. 28(47):67108-67119

Zhang, T., Xu, Z., Wen, L., Lei, D., Li, S., Wang, J., Huang, J., Wang, N., Durkan, C., Liao, X., Wang, G. (2021) Cadmium-induced dysfunction of the blood-brain barrier depends on ROS-mediated inhibition of PTPase activity in zebrafish. Journal of hazardous materials. 412:125198

Sun, X., Zhou, Y., Zhang, R., Wang, Z., Xu, M., Zhang, D., Huang, J., Luo, F., Li, F., Ni, Z., Zhou, S., Chen, H., Chen, S., Chen, L., Du, X., Chen, B., Huang, H., Liu, P., Yin, L., Qiu, J., Chen, D., Deng, C., Xie, Y., Luo, L., Chen, L. (2020) Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway. Nature communications. 11:479

Wang, L., Wang, Q., Xiao, G., Chen, G., Han, L., Hu, T. (2019) Adverse effect of cylindrospermopsin on embryonic development in zebrafish (Danio rerio). Chemosphere. 241:125060

Ge, S., Xi, Y., Du, R., Ren, Y., Xu, Z., Tan, Y., Wang, Y., Yin, T., Wang, G. (2019) Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility. Regenerative biomaterials. 6:299-309

Huang, L., Tjakra, M., Luo, D., Wen, L., Lei, D., Wang, J., Yin, T., Zhang, X., Huang, J., Wang, Y., Wang, G. (2019) FoxF1 is Required for Ciliogenesis and Distribution of Sonic Hedgehog Signaling Components in Cilium. Current Molecular Medicine. 19(5):326-334

Xie, X., Lei, D., Zhang, Q., Wang, Y., Wen, L., Ye, Z., Ud Din, A., Jia, D., Apicella, A., Wang, G. (2019) Effect of simulated microgravity induced PI3K-nos2b signalling on zebrafish cardiovascular plexus network formation. Journal of biomechanics. 87:83-92

Wang, Q., Liu, Y., Guo, J., Lin, S., Wang, Y., Yin, T., Gregersen, H., Hu, T., Wang, G. (2018) Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway. Chemosphere. 218:438-448

Luo, L., Wu, W., Sun, D., Dai, H.B., Wang, Y., Zhong, Y., Wang, J.X., Maruf, A., Nurhidayah, D., Zhang, X.J., Wang, Y., Wang, G.X. (2018) Acid-Activated Melittin for Targeted and Safe Antitumor Therapy. Bioconjugate Chemistry. 29:2936-2944

Xie, X., Zhou, T., Wang, Y., Chen, H., Lei, D., Huang, L., Wang, Y., Jin, X., Sun, T., Tan, J., Yin, T., Huang, J., Gregersen, H., Wang, G. (2018) Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling. Current Molecular Medicine. 18(1):3-14

Chen, J., Wu, Q., Luo, L., Wang, Y., Zhong, Y., Dai, H.B., Sun, D., Luo, M.L., Wu, W., Wang, G.X. (2017) Dual tumor-targeted poly(lactic-co-glycolic acid)-polyethylene glycol-folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery.. International Journal of Nanomedicine. 12:5745-5760

Zou, D., Wang, W., Lei, D., Yin, Y., Ren, P., Chen, J., Yin, T., Wang, B., Wang, G., Wang, Y. (2017) Penetration of blood-brain barrier and antitumor activity and nerve repair in glioma by doxorubicin-loaded monosialoganglioside micelles system. International Journal of Nanomedicine. 12:4879-4889

Chen, J., Wu, X., Yao, L., Yan, L., Zhang, L., Qiu, J., Liu, X., Jia, S., Meng, A. (2017) Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos.. The Journal of biological chemistry. 292(6):2315-2327

Zhou, T., Dong, Q., Shen, Y., Wu, W., Wu, H., Luo, X., Liao, X., Wang, G. (2016) PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish.. International Journal of Nanomedicine. 11:6517-6531

Xie, X., Lei, D., Liu, Y., Huang, L., Zhou, T., Wang, Y., Wang, G. (2015) S22 is required in the process of blood flow regulate the vascular development in zebrafish. Biorheology. 52(1-2):112

Sun, T., Xie, X., Zhang, J.Q., Bao, J., Tang, C.Z., Lei, D.X., Qiu, J.H., and Wang, G.X. (2013) Effect of horizontal rotary culture on zebrafish vascular development. Yi chuan = Hereditas. 35(4):502-510

Xie, X., Tan, J., Wei, D., Lei, D., Yin, T., Huang, J., Zhang, X., Qiu, J., Tang, C., and Wang, G. (2013) In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish. Journal of the Royal Society, Interface. 10(82):20121053

Tan, J., Wang, G.X., Xie, X., Tang, C.J., Qiu, J.H., Luo, L.F. (2010) Model establishment of lipoprotein accumulation observation in vivo in zebrafish. Hypertension (Dallas, Tex. : 1979). 56(6):1180

Wang, Y., Kaiser, M.S., Larson, J.D., Nasevicius, A., Clark, K.J., Wadman, S.A., Roberg-Perez, S.E., Ekker, S.C., Hackett, P.B., McGrail, M., and Essner, J.J. (2010) Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development (Cambridge, England). 137(18):3119-3128