ZFIN ID: ZDB-LAB-170207-4
Woo Lab
PI/Director: Woo, Stephanie
Contact Person: Woo, Stephanie
Email: swoo6@ucmerced.edu
URL:
Address: University of California Merced SE1 253 5200 N. Lake Rd. Merced, CA 95343
Country: United States
Phone: (209) 228-4016
Fax: (209) 228-4060
Line Designation: sfc


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 3 genomic features


STATEMENT OF RESEARCH INTERESTS
Endoderm development and epithelial morphogenesis in zebrafish

Our lab is interested in how morphogenetic movements are coordinated with cell specification and differentiation programs. In particular we are interested in how these processes are regulated during development of the gastrointestinal epithelium, which is derived from the endoderm. In zebrafish, endodermal cells are specified just prior to gastrulation and soon after become highly motile and quickly disperse across the inner surface of the embryo. These scattered cells then undergo a switch in migratory behavior to converge into a coherent endodermal sheet, which ultimately gives rise to the epithelial lining of the gut tube. Our lab has developed techniques to image these cells in vivo at single- and sub-cellular resolution, which we are using to explore 1) how these cells initiate epithelial sheet formation and develop into a functional GI tract and 2) how defects in epithelial morphogenesis can contribute to gastrointestinal diseases such as inflammatory bowel disease.


LAB MEMBERS
Materna, Stefan Post-Doc


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Liu, Z., Woo, S., Weiner, O.D. (2018) Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation. Development (Cambridge, England). 145(17):
Hu, B., Gao, Y., Davies, L., Woo, S., Topczewski, J., Jessen, J.R., Lin, F. (2018) Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition. Development (Cambridge, England). 145(17):
Reade, A., Motta-Mena, L.B., Gardner, K.H., Stainier, D.Y., Weiner, O.D., Woo, S. (2017) TAEL: A zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development (Cambridge, England). 144(2):345-355
Woo, S., Housley, M.P., Weiner, O.D., and Stainier, D.Y. (2012) Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. The Journal of cell biology. 198(5):941-952
Fish, J.E., Wythe, J.D., Xiao, T., Bruneau, B.G., Stainier, D.Y., Srivastava, D., and Woo, S. (2011) A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development (Cambridge, England). 138(7):1409-1419
Woo, S., Rowan, D.J., and Gomez, T.M. (2009) Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(44):13981-13991