ZFIN ID: ZDB-LAB-161220-5
Darras Lab
PI/Director: Darras, Veerle
Contact Person: Darras, Veerle
Email: veerle.darras@kuleuven.be
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Line Designation: lv


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Houbrechts, A.M., Beckers, A., Vancamp, P., Sergeys, J., Gysemans, C., Mathieu, C., Darras, V.M. (2019) Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish. Endocrinology. 160(11):2759-2772
Houbrechts, A.M., Van Houcke, J., Darras, V.M. (2019) Disruption of deiodinase type 2 in zebrafish disturbs male and female reproduction. The Journal of endocrinology.
Vancamp, P., Bourgeois, N.M.A., Houbrechts, A.M., Darras, V.M. (2018) Knockdown of the thyroid hormone transporter MCT8 in chicken retinal precursor cells hampers early retinal development and results in a shift towards more UV/blue cones at the expense of green/red cones. Experimental Eye Research. 178:135-147
Vancamp, P., Houbrechts, A.M., Darras, V.M. (2018) Insights from zebrafish deficiency models to understand the impact of local thyroid hormone regulator action on early development. General and comparative endocrinology. 279:45-52
Stinckens, E., Vergauwen, L., Ankley, G.T., Blust, R., Darras, V.M., Villeneuve, D.L., Witters, H., Volz, D.C., Knapen, D. (2018) An AOP-based alternative testing strategy to predict the impact of thyroid hormone disruption on swim bladder inflation in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 200:1-12
Vancamp, P., Darras, V.M. (2017) From zebrafish to human: A comparative approach to elucidate the role of the thyroid hormone transporter MCT8 during brain development. General and comparative endocrinology. 265:219-229
van der Spek, A.H., Jim, K.K., Karaczyn, A., van Beeren, H.C., Ackermans, M.T., Darras, V.M., Vandenbroucke-Grauls, C.M.J.E., Hernandez, A., Brouwer, M.C., Fliers, E., van de Beek, D., Boelen, A. (2017) The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species. Endocrinology. 159(2):826-835
Houbrechts, A.M., Delarue, J., Gabriƫls, I.J., Sourbron, J., Darras, V.M. (2016) Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility. Endocrinology. 157:3668-81
Lemmens, K., Bollaerts, I., Bhumika, S., De Groef, L., Van Houcke, J., Darras, V.M., Van Hove, I., Moons, L. (2016) Matrix metalloproteinases as promising regulators of axonal regrowth in the injured adult zebrafish retinotectal system. The Journal of comparative neurology. 524(7):1472-93
Houbrechts, A.M., Vergauwen, L., Bagci, E., Van Houcke, J., Heijlen, M., Kulemeka, B., Hyde, D.R., Knapen, D., Darras, V.M. (2016) Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Molecular and Cellular Endocrinology. 424:81-93
Bhumika, S., Lemmens, K., Vancamp, P., Moons, L., Darras, V.M. (2015) Decreased thyroid hormone signaling accelerates the reinnervation of the optic tectum following optic nerve crush in adult zebrafish. Molecular and cellular neurosciences. 68:92-102
Bagci, E., Heijlen, M., Vergauwen, L., Hagenaars, A., Houbrechts, A.M., Esguerra, C.V., Blust, R., Darras, V.M., Knapen, D. (2015) Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction. PLoS One. 10:e0123285
Darras, V.M., Houbrechts, A.M., Van Herck, S.L. (2015) Intracellular thyroid hormone metabolism as a local regulator of nuclear thyroid hormone receptor-mediated impact on vertebrate development. Biochimica et biophysica acta. Gene regulatory mechanisms. 1849(2):130-141
Heijlen, M., Houbrechts, A.M., Bagci, E., Van Herck, S.L., Kersseboom, S., Esguerra, C.V., Blust, R., Visser, T.J., Knapen, D., and Darras, V.M. (2014) Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. 155(4):1547-1559
Heijlen, M., Houbrechts, A.M., and Darras, V.M. (2013) Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development. General and comparative endocrinology. 188:289-96
Janssens, E., Gaublomme, D., De Groef, L., Darras, V.M., Arckens, L., Delorme, N., Claes, F., Van Hove, I., and Moons, L. (2013) Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development. PLoS One. 8(1):e52915
Darras, V.M., Van Herck, S.L., Heijlen, M., and De Groef, B. (2011) Thyroid hormone receptors in two model species for vertebrate embryonic development: chicken and zebrafish. Journal of Thyroid Research. 2011:402320
Walpita, C.N., Crawford, A.D., and Darras, V.M. (2010) Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio). General and comparative endocrinology. 166(1):134-141