ZFIN Lab: Jun Chen Lab

ZFIN ID: ZDB-LAB-151209-1

Jun Chen Lab

PI/Director:	Chen, Jun
Contact Person:	Chen, Jun
Email:	chenjun2009@zju.edu.cn
URL:	http://mypage.zju.edu.cn/chenjun
Address:	College of Life Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, China 310058
Country:	China
Phone:	86-571-88982101
Fax:	86-571-88982101
Line Designation:	zju

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 34 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Jin, Q., Hu, Y., Gao, Y., Zheng, J., Chen, J., Gao, C., Peng, J. (2023) Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish. Biochemical and Biophysical Research Communications. 686:149182149182

Xie, A., Ma, Z., Wang, J., Zhang, Y., Chen, Y., Yang, C., Chen, J., Peng, J. (2023) Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner. Cell discovery. 9:6363

Wei, J., Wang, S., Zhu, H., Cui, W., Gao, J., Gao, C., Yu, B., Liu, B., Chen, J., Peng, J. (2023) Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation. iScience. 26:107220107220

Tang, Z., Wang, K., Lo, L., Chen, J. (2023) Tg(Δ113p53:cmyc) Transgene Upregulates glut1 Expression to Promote Zebrafish Heart Regeneration. Journal of cardiovascular development and disease. 10(6):

Jin, Q., Gao, Y., Shuai, S., Chen, Y., Wang, K., Chen, J., Peng, J., Gao, C. (2022) Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification. Journal of genetics and genomics = Yi chuan xue bao. 49(12):1101-1113

Xia, C., Tian, L., Yu, J., Lu, X., Wang, H., He, Z., Qian, B., Gu, L., Wang, L., Chen, J., Lu, T., Xu, C., Qian, H., Sun, L. (2022) Inhibitory effects of estrogenic endocrine disrupting chemicals on fin regeneration in zebrafish are dependent on estrogen receptors. Aquatic toxicology (Amsterdam, Netherlands). 247:106156

Zhu, Y., Wang, Y., Tao, B., Han, J., Chen, H., Zhu, Q., Huang, L., He, Y., Hong, J., Li, Y., Chen, J., Huang, J., Lo, L.J., Peng, J. (2021) Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication. Journal of molecular cell biology. 13(12):902-917

Zhao, T., Ye, S., Tang, Z., Guo, L., Ma, Z., Zhang, Y., Yang, C., Peng, J., Chen, J. (2021) Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish. Cell Death & Disease. 12:151

Ye, S., Zhao, T., Zhang, W., Tang, Z., Gao, C., Ma, Z., Xiong, J.W., Peng, J., Tan, W.Q., Chen, J. (2020) p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Cell Death & Disease. 11:568

Gong, L., Zhang, Q., Pan, X., Chen, S., Yang, L., Liu, B., Yang, W., Yu, L., Xiao, Z.X., Feng, X.H., Wang, H., Yuan, Z.M., Peng, J., Tan, W.Q., Chen, J. (2019) p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell Reports. 29:3693-3707.e5

Ding, Y., Dvornikov, A.V., Ma, X., Zhang, H., Wang, Y., Lowerison, M., Packard, R.R., Wang, L., Chen, J., Zhang, Y., Hsiai, T., Lin, X., Xu, X. (2019) Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Disease models & mechanisms. 12(10):

Ma, Z., Zhu, P., Shi, H., Guo, L., Zhang, Q., Chen, Y., Chen, S., Zhang, Z., Peng, J., Chen, J. (2019) PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Nature. 568(7751):259-263

Zhao, S., Chen, Y., Chen, F., Huang, D., Shi, H., Lo, L.J., Chen, J., Peng, J. (2019) Sas10 controls ribosome biogenesis by stabilizing Mpp10 and delivering the Mpp10-Imp3-Imp4 complex to nucleolus. Nucleic acids research. 47(6):2996-3012

Gao, C., Huang, W., Gao, Y., Jan Lo, L., Luo, L., Huang, H., Chen, J., Peng, J. (2018) Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1. Journal of molecular cell biology. 11(6):448-462

Gao, C., Zhu, Z., Gao, Y., Lo, L.J., Chen, J., Luo, L., Peng, J. (2018) Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes. Journal of genetics and genomics = Yi chuan xue bao. 45:173-175

Zhu, P., Ma, Z., Guo, L., Zhang, W., Zhang, Q., Zhao, T., Jiang, K., Peng, J., Chen, J. (2017) Short body length phenotype is compensated by the upregulation of nidogen family members in a deleterious nid1a mutation of zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 44(11):553-556

Ma, Z., Zhu, P., Pang, M., Guo, L., Chang, N., Zheng, J., Zhu, X., Gao, C., Huang, H., Cui, Z., Xiong, J.W., Peng, J., Chen, J. (2017) A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Scientific Reports. 7:10381

Hou, J., Su, Y., Lin, W., Guo, H., Xie, P., Chen, J., Gu, Z., Li, L. (2017) Microcystin-LR retards gonadal maturation through disrupting the growth hormone/insulin-like growth factors system in zebrafish. Ecotoxicology and environmental safety. 139:27-35

Chen, L., Hu, Y., He, J., Chen, J., Giesy, J.P., Xie, P. (2017) Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Environmental science & technology. 51(1):596-607

Tuo, X., Chen, J., Zhao, S., Xie, P. (2016) Chemical proteomic analysis of the potential toxicological mechanisms of microcystin-RR in zebrafish (Danio rerio) liver. Environmental toxicology. 31(10):1206-16

Guan, Y., Huang, D., Chen, F., Gao, C., Tao, T., Shi, H., Zhao, S., Liao, Z., Lo, L.J., Wang, Y., Chen, J., Peng, J. (2016) Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3. PLoS Biology. 14:e1002555e1002555

Wang, Y., Zhu, Q., Huang, L., Zhu, Y., Chen, J., Peng, J., Lo, L.J. (2016) Interaction between Bms1 and Rcl1, two ribosome biogenesis factors, is evolutionally conserved in zebrafish and human. Journal of genetics and genomics = Yi chuan xue bao. 43(7):467-9

Li, Q., Wang, X., Dai, T., Liu, C., Li, T., McClements, D.J., Chen, J., Liu, J. (2016) Proanthocyanidins, Isolated from Choerospondias axillaris Fruit Peels, Exhibit Potent Antioxidant Activities in Vitro and Novel Anti-angiogenic Property in Vitro and in Vivo. Journal of Agricultural and Food Chemistry. 64(18):3546-56

Cai, Y., Zhang, C., Hao, L., Chen, J., Xie, P., Chen, Z. (2016) Systematic identification of seven ribosomal protein genes in bighead carp and their expression in response to microcystin-LR. The Journal of Toxicological Sciences. 41:293-302

Hu, M., Bai, Y., Zhang, C., Liu, F., Cui, Z., Chen, J., Peng, J. (2016) Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genetics. 12:e1005881

Chen, J., Peng, J. (2015) Δ113p53/Δ133p53: survival and integrity. Oncotarget. 6:13850-1