ZFIN ID: ZDB-LAB-150304-1
Kindt Lab
PI/Director:
Contact Person:
Email: katie.kindt@nih.gov
URL:
Address: National Institute on Deafness and Other Communication Disorders Building 35A, Room 1D 908 35A Convent Drive Bethesda, MD 20892 USA
Country: United States
Phone: 301-402-2684
Fax:
Line Designation: idc


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 14 genomic features


STATEMENT OF RESEARCH INTERESTS
Auditory and vestibular systems are required for proper hearing and
balance. These systems require sensory hair cells of the inner ear, to
sense sound and process vestibular stimuli. To reliably transmit auditory
and vestibular information, hair cells use specialized pre-synaptic
structures called synaptic ribbons. Our studies combine genetic,
molecular, and imaging-based approaches to identify the structural and
functional processes underlying synapse formation in hair cells. For our
studies we use the zebrafish lateral-line system in order to study
hair-cell development and function, in a live, transparent preparation. We
have an extremely powerful collection of transgenic zebrafish that label
synaptic structures to either assess synaptic morphology or function using
genetically encoded fluorescent proteins. We are combining these
microscopy-based approaches with CRISPR technology to create mutant
zebrafish in order to identify genes required for synapse formation,
function and regeneration. With this knowledge we aim to apply our
understanding of these processes in order to understand how to properly
reform hair cells and synaptic structures when they are loss or damaged
after hearing loss.


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