ZFIN ID: ZDB-LAB-150205-3
Panáková Lab
PI/Director: Panáková, Daniela
Contact Person: Panáková, Daniela
Email: daniela.panakova@uksh.de
URL: https://www.mdc-berlin.de/35567762/en/research/research_teams/electrochemical_signaling_in_cell_development_and_disease
Address: Max Delbrück Center for Molecular Medicine, Robert Rössle Str. 10, 13125 Berlin, Germany
Country: Germany
Phone: +49 30 9406 2730
Fax: +49 30 9406 2394
Line Designation: md


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
Our research interest lies in understanding the interplay between development and physiology during embryonic development. We focus on the mechanisms that underly the formation of functional cardiac syncytium.


LAB MEMBERS
Bartolini, Laura Graduate Student Csalyi, Kitti Graduate Student Merks, Anne Graduate Student
Swinarski, Marie Graduate Student Meyer, Alexander Research Staff Richter, Jana Research Staff
Schulz, Christina Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Kourpa, A., Schulz, A., Mangelsen, E., Kaiser-Graf, D., Koppers, N., Stoll, M., Rothe, M., Bader, M., Purfürst, B., Kunz, S., Gladytz, T., Niendorf, T., Bachmann, S., Mutig, K., Bolbrinker, J., Panáková, D., Kreutz, R. (2023) Studies in Zebra Fish and Rat Models Support Dual Blockade of EP2 and EP4 (Prostaglandin E2 Receptors Type 2 and 4) for Renoprotection in Glomerular Hyperfiltration and Albuminuria. Hypertension (Dallas, Tex. : 1979). 80(4):771-782
Kourpa, A., Kaiser-Graf, D., Sporbert, A., Philippe, A., Catar, R., Rothe, M., Mangelsen, E., Schulz, A., Bolbrinker, J., Kreutz, R., Panáková, D. (2022) 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life sciences. 310:121114
Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D., Junker, J.P. (2022) Origin and function of activated fibroblast states during zebrafish heart regeneration. Nature Genetics. 54(8):1227-1237
McGarvey, A.C., Kopp, W., Vučićević, D., Mattonet, K., Kempfer, R., Hirsekorn, A., Bilić, I., Gil, M., Trinks, A., Merks, A.M., Panáková, D., Pombo, A., Akalin, A., Junker, J.P., Stainier, D.Y.R., Garfield, D., Ohler, U., Lacadie, S.A. (2022) Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos. Cell genomics. 2:100083100083
Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M., Weinstein, B.M. (2019) Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in cell and developmental biology. 7:89
Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730
Kny, M., Csályi, K.D., Klaeske, K., Busch, K., Meyer, A.M., Merks, A.M., Darm, K., Dworatzek, E., Fliegner, D., Baczko, I., Regitz-Zagrosek, V., Butter, C., Luft, F.C., Panáková, D., Fielitz, J. (2019) Ninjurin1 regulates striated muscle growth and differentiation. PLoS One. 14:e0216987
Schulz, A., Müller, N.V., van de Lest, N.A., Eisenreich, A., Schmidbauer, M., Barysenka, A., Purfürst, B., Sporbert, A., Lorenzen, T., Meyer, A.M., Herlan, L., Witten, A., Rühle, F., Zhou, W., de Heer, E., Scharpfenecker, M., Panáková, D., Stoll, M., Kreutz, R. (2019) Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. eLIFE. 8:
Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
Felker, A., Prummel, K.D., Merks, A.M., Mickoleit, M., Brombacher, E.C., Huisken, J., Panáková, D., Mosimann, C. (2018) Continuous addition of progenitors forms the cardiac ventricle in zebrafish. Nature communications. 9:2001
Weber, M., Scherf, N., Meyer, A.M., Panáková, D., Kohl, P., Huisken, J. (2017) Cell-accurate optical mapping across the entire developing heart. eLIFE. 6
Kreutz, R., Schulz, A., Meyer, A.M., Lorenzen, T., Stoll, M., Panakova, D. (2016) Functional analysis of tmem63c in zebrafish reveals its role as a novel candidate for albuminuria and chronic kidney disease. Journal of hypertension. 34 Suppl 2 - ESH 2016 Abstract Book:e51
Musso, G., Mosimann, C., Panáková, D., Burger, A., Zhou, Y., Zon, L.I., MacRae, C.A. (2015) Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genomics Data. 6:199-201
Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K., Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A., Zon, L.I. (2015) Chamber identity programs drive early functional partitioning of the heart. Nature communications. 6:8146
Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G., Traver, D. (2014) Discrete Notch signaling requirements in the specification of hematopoietic stem cells. The EMBO journal. 33(20):2363-73
Panáková, D., Werdich, A.A., and MacRae, C.A. (2010) Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 466(7308):874-878