ZFIN ID: ZDB-LAB-140902-2
Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" (Neurosciences and Behavior Lab)
PI/Director: Maximino, Caio
Co-PI / Senior
Researcher:		 Lima, Monica Gomes
Contact Person: Maximino, Caio
Email: cmaximino@unifesspa.edu.br
URL:
Address: Universidade Federal do Sul e Sudeste do Pará - Unifesspa
Country: Brazil
Phone: +55-94-2101-7121
Fax:
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Our laboratory combines behavioural and pharmacological techniques to investigate the neural mechanisms of anxiety, fear and stress using zebrafish as a model system. In order to exploit the potential of zebrafish in this area we have developed behavioural assays of anxiety and fear in adult zebrafish and have initiated a neuropharmacology programme to identify the biological mechanisms contributing to behavioural phenotypes associated with psychiatric disorders.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
do Nascimento, B.G., Maximino, C. (2023) Social investigation and social novelty in zebrafish: Roles of salience and novelty. Behavioural processes. 210:104903
de Moura, L.A., Pyterson, M.P., Pimentel, A.F.N., Araújo, F., de Souza, L.V.X.B., Mendes, C.H.M., Costa, B.P.D., de Siqueira-Silva, D.H., Lima-Maximino, M., Maximino, C. (2023) Roles of the 5-HT2C receptor on zebrafish sociality. Progress in neuro-psychopharmacology & biological psychiatry. 125:110769
Bozi, B., Rodrigues, J., Lima-Maximino, M., de Siqueira-Silva, D.H., Soares, M.C., Maximino, C. (2021) Social Stress Increases Anxiety-Like Behavior Equally in Male and Female Zebrafish. Frontiers in behavioral neuroscience. 15:785656
do Carmo Silva, R.X., do Nascimento, B.G., Gomes, G.C.V., da Silva, N.A.H., Pinheiro, J.S., da Silva Chaves, S.N., Pimentel, A.F.N., Costa, B.P.D., Herculano, A.M., Lima-Maximino, M., Maximino, C. (2021) 5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish. Pharmacology, biochemistry, and behavior. 210:173276
German-Ponciano, L.J., Dutra Costa, B.P., Feitosa, L.M., Campos, K.D.S., Nayara da Silva Chaves, S., Cueto-Escobedo, J., Lima-Maximino, M., Rodríguez-Landa, J.F., Maximino, C. (2020) Chrysin, but not flavone backbone, decreases anxiety-like behavior in animal screens. Neurochemistry international. 140:104850
do Nascimento, B.G., Oliveira, H.S.T.O.E., Silva, H.T.L., de Siqueira-Silva, D.H., Lima-Maximino, M., Maximino, C. (2020) A model to study orienting responses in zebrafish, and applications towards the emotion-cognition interaction. Animal cognition. 23(5):965-972
Lima-Maximino, M., Pyterson, M.P., do Carmo Silva, R.X., Gomes, G.C.V., Rocha, S.P., Herculano, A.M., Rosemberg, D.B., Maximino, C. (2020) Phasic and tonic serotonin modulate alarm reactions and post-exposure behavior in zebrafish. Journal of neurochemistry. 153(4):495-509
de Abreu, M.S., Maximino, C., Banha, F., Anastácio, P.M., Demin, K.A., Kalueff, A.V., Soares, M.C. (2019) Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish. Journal of neuroscience research. 98(5):764-779
Santos, B.R.D., Santos, R.C.D., Dias, C.A.G.M., Maximino, C., Gouveia, A. (2019) White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning. Zebrafish. 16(5):443-450
Maruska, K., Soares, M.C., Lima-Maximino, M., Henrique de Siqueira-Silva, D., Maximino, C. (2019) Social plasticity in the fish brain: Neuroscientific and ethological aspects. Brain research. 1711:156-172
Maximino, C., do Carmo Silva, R.X., Dos Santos Campos, K., de Oliveira, J.S., Rocha, S.P., Pyterson, M.P., Dos Santos Souza, D.P., Feitosa, L.M., Ikeda, S.R., Pimentel, A.F.N., Ramos, P.N.F., Costa, B.P.D., Herculano, A.M., Rosemberg, D.B., da Silva, D.H.S., Lima-Maximino, M. (2018) Sensory ecology of ostariophysan alarm substances. Journal of Fish Biology. 95(1):274-286
Barbosa, H.P., Lima-Maximino, M.G., Maximino, C. (2018) Acute fluoxetine differently affects aggressive display in zebrafish phenotypes. Aggressive behavior. 45(1):62-69
Soares, M.C., Gerlai, R., Maximino, C. (2018) The integration of sociality, monoamines and stress neuroendocrinology in fish models: Applications in the neurosciences. Journal of Fish Biology. 93(2):170-191
Lima, M.G., Cueto-Escobedo, J., Rodríguez-Landa, J.F., Maximino, C. (2018) FGIN-1-27, an agonist at translocator protein 18 kDa (TSPO), produces anti-anxiety and anti-panic effects in non-mammalian models. Pharmacology, biochemistry, and behavior. 171:66-73
da Silva Chaves, S.N., Rocha, G.F., Costa, B.P.D., de Oliveira, W.E.A., Lima, M.G., de Siqueira Silva, D.H., Maximino, C. (2018) Behavioral and biochemical effects of ethanol withdrawal in zebrafish. Pharmacology, biochemistry, and behavior. 169:48-58
Maximino, C., Meinerz, D.L., Fontana, B.D., Mezzomo, N.J., Stefanello, F.V., de S Prestes, A., Batista, C.B., Rubin, M.A., Barbosa, N.V., Rocha, J.B.T., Lima, M.G., Rosemberg, D.B. (2018) Extending the analysis of zebrafish behavioral endophenotypes for modeling psychiatric disorders: Fear conditioning to conspecific alarm response. Behavioural processes. 149:35-42
Soares, M.C., Cardoso, S.C., Dos Santos Carvalho, T., Maximino, C. (2017) The use of model fish as tools for research the biological mechanisms of cooperative behaviour: A future for translational research concerning social anxiety disorders?. Progress in neuro-psychopharmacology & biological psychiatry. 82:205-215
Kysil, E.V., Meshalkina, D.A., Frick, E.E., Echevarria, D.J., Rosemberg, D.B., Maximino, C., Lima, M.G., Abreu, M.S., Giacomini, A.C., Barcellos, L.J.G., Song, C., Kalueff, A.V. (2017) Comparative Analyses of Zebrafish Anxiety-Like Behavior Using Conflict-Based Novelty Tests. Zebrafish. 14(3):197-208
Lima, M.G., Silva, R.X., Silva, S.N., Rodrigues, L.D., Oliveira, K.R., Batista, E.J., Maximino, C., Herculano, A.M. (2016) Time-dependent sensitization of stress responses in zebrafish: A putative model for post-traumatic stress disorder. Behavioural processes. 128:70-82
Lima, M.G., Rodrigues, S.N., Silva, R.X., Oliveira, K.R., Batista, E.J., Maximino, C., Herculano, A.M. (2015) Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish. Pharmacology, biochemistry, and behavior. 139 Pt B:127-33
Maximino, C., Silva, R.X., da Silva, S.N., Rodrigues, L.D., Barbosa, H., de Carvalho, T.S., Leão, L.K., Lima, M.G., Oliveira, K.R., Herculano, A.M. (2015) Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry. Frontiers in behavioral neuroscience. 9:233
Maximino, C., Gemaque, J., Benzecry, R., Lima, M.G., Batista, E.D., Picanço-Diniz, D.W., Oliveira, K.R., Herculano, A.M. (2015) Role of nitric oxide in the behavioral and neurochemical effects of IB-MECA in zebrafish. Psychopharmacology. 232(10):1671-80
Maximino, C., Lima, M.G., Batista, E.J., Oliveira, K.R., Herculano, A.M. (2015) Interaction between 5-HT1B receptors and nitric oxide in zebrafish responses to novelty. Neuroscience letters. 588:54-6
Herculano, A.M., Puty, B., Miranda, V., Lima, M.G., Maximino, C. (2015) Interactions between serotonin and glutamate-nitric oxide pathways in zebrafish scototaxis. Pharmacology, biochemistry, and behavior. 129:97-104
Herculano, A.M., Maximino, C. (2014) Serotonergic modulation of zebrafish behavior: Towards a paradox. Progress in neuro-psychopharmacology & biological psychiatry. 55:50-66
Stewart, A.M., Grossman, L., Nguyen, M., Maximino, C., Rosemberg, D.B., Echevarria, D.J., Kalueff, A.V. (2014) Aquatic toxicology of fluoxetine: Understanding the knowns and the unknowns. Aquatic toxicology (Amsterdam, Netherlands). 156:269-73
Maximino, C., Lima, M.G., Costa, C.C., Guedes, I.M., Herculano, A.M. (2014) Fluoxetine and WAY 100,635 dissociate increases in scototaxis and analgesia induced by conspecific alarm substance in zebrafish (Danio rerio Hamilton 1822). Pharmacology, biochemistry, and behavior. 124:425-33
Puty, B., Maximino, C., Brasil, A., da Silva, W.L., Gouveia, A., Oliveira, K.R., Batista, E.D., Crespo-Lopez, M.E., Rocha, F.A., Herculano, A.M. (2014) Ascorbic Acid Protects Against Anxiogenic-Like Effect Induced by Methylmercury in Zebrafish: Action on the Serotonergic System. Zebrafish. 11(4):365-70
Maximino, C., da Silva, A.W., Araújo, J., Lima, M.G., Miranda, V., Puty, B., Benzecry, R., Picanço-Diniz, D.L., Gouveia, A., Oliveira, K.R., Herculano, A.M. (2014) Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors. PLoS One. 9:e103943
Maximino, C., Puty, B., Benzecry, R., Araújo, J., Lima, M.G., de Jesus Oliveira Batista, E., Renata de Matos Oliveira, K., Crespo-Lopez, M.E., and Herculano, A.M. (2013) Role of serotonin in zebrafish (Danio rerio) anxiety: Relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine (pCPA) in two behavioral models. Neuropharmacology. 71:83-97
Maximino, C., Puty, B., Matos Oliveira, K.R., and Herculano, A.M. (2013) Behavioral and neurochemical changes in the zebrafish leopard strain. Genes, brain, and behavior. 12(5):576-82
Maximino, C., Lima, M.G., Oliveira, K.R., Batista, E.D., and Herculano, A.M. (2013) "Limbic associative" and "autonomic" amygdala in teleosts: A review of the evidence. Journal of chemical neuroanatomy. 48-49:1-13
Maximino, C., Araújo, J., Leão, L.K., Grisolia, A.B., Oliveira, K.R., Lima, M.G., Batista, E.D., Crespo-López, M.E., Gouveia, A., and Herculano, A.M. (2011) Possible role of serotoninergic system in the neurobehavioral impairment induced by acute methylmercury exposure in zebrafish (Danio rerio). Neurotoxicology and teratology. 33(6):727-34
Maximino, C., and Herculano, A.M. (2011) Adenosine A(1) , but not A(2) , Receptor Blockade Increases Anxiety and Arousal in Zebrafish. Basic & Clinical Pharmacology & Toxicology. 109(3):203-7
Maximino, C., da Silva, A.W., Gouveia, A. Jr, and Herculano, A.M. (2011) Pharmacological analysis of zebrafish (Danio rerio) scototaxis. Progress in neuro-psychopharmacology & biological psychiatry. 35(2):624-631
Maximino, C., Brito, T.M., Batista, A.W., Herculano, A.M., Morato, S., and Jr, A.G. (2010) Measuring anxiety in zebrafish: A critical review. Behavioural brain research. 214(2):157-171
Maximino, C., and Herculano, A.M. (2010) A review of monoaminergic neuropsychopharmacology in zebrafish. Zebrafish. 7(4):359-378
Maximino, C., Brito, T.M., Colmanetti, R., Pontes, A.A., Castro, H.M., Lacerda, R.I., Morato, S., and Jr, A.G. (2010) Parametric analyses of anxiety in zebrafish scototaxis. Behavioural brain research. 210(1):1-7
Maximino, C., Marques de Brito, T., Dias, C.A., Gouveia, A. Jr, and Morato, S. (2010) Scototaxis as anxiety-like behavior in fish. Nature Protocols. 5(2):209-216
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