ZFIN ID: ZDB-LAB-131024-2
Moro Lab
PI/Director: Moro, Enrico
Contact Person: Moro, Enrico
Email: moroe@bio.unipd.it; enrico.moro.1@unipd.it
URL:
Address: Department of Molecular Medicine University of Padova Via U.Bassi 58/ B 35121 Padova (Italy)
Country: Italy
Phone: +390498276341
Fax: +390498276300
Line Designation: ia


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 1 genomic features


STATEMENT OF RESEARCH INTERESTS
My group is currently involved in using zebrafish to model lysosomal storage disorders (LSD), particularly the Hunter syndrome and Gaucher disease. We are exploiting several in vivo approaches to dissect early molecular events involved in cellular abnormalities detected in fish morphants and mutants for lysosome-associated proteins. We are particularly focused in the bone and heart compartments, as in some of the investigated disorders these tissues are severely compromised.
We are also trying to translate the observed results in mouse models and perform also a preliminary molecular characterization of affected patients.


LAB MEMBERS
Rubin, Michela Graduate Student Badenetti, Lorenzo Research Staff Manzoli, Rosa Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Guglielmi, L., Bühler, A., Moro, E., Argenton, F., Poggi, L., Carl, M. (2020) Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry. Development (Cambridge, England). 147(6):
Costa, R., Bellesso, S., Lualdi, S., Manzoli, R., Pistorio, V., Filocamo, M., Moro, E. (2020) A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models. Human molecular genetics. 29:285
Costa, R., Peruzzo, R., Bachmann, M., Montà, G.D., Vicario, M., Santinon, G., Mattarei, A., Moro, E., Quintana-Cabrera, R., Scorrano, L., Zeviani, M., Vallese, F., Zoratti, M., Paradisi, C., Argenton, F., Brini, M., Calì, T., Dupont, S., Szabò, I., Leanza, L. (2019) Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Cell Reports. 28:1949-1960.e6
Cozza, G., Moro, E., Black, M., Marin, O., Salvi, M., Venerando, A., Tagliabracci, V.S., Pinna, L.A. (2018) The Golgi "casein kinase" Fam20C is a genuine "phosvitin kinase" and phosphorylates polyserine stretches devoid of the canonical consensus. The FEBS journal. 285(24):4674-4683
Bellesso, S., Salvalaio, M., Lualdi, S., Tognon, E., Costa, R., Braghetta, P., Giraudo, C., Stramare, R., Rigon, L., Filocamo, M., Tomanin, R., Moro, E. (2018) FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII). Human molecular genetics. 27:2262-2275
Costa, R., Urbani, A., Salvalaio, M., Bellesso, S., Cieri, D., Zancan, I., Filocamo, M., Bonaldo, P., Szabò, I., Tomanin, R., Moro, E. (2017) Perturbations in cell signaling elicit early cardiac defects in mucopolysaccharidosis type II. Human molecular genetics. 26(9):1643-1655
Zancan, I., Bellesso, S., Costa, R., Salvalaio, M., Stroppiano, M., Hammond, C., Argenton, F., Filocamo, M., Moro, E. (2015) Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling. Human molecular genetics. 24(5):1280-94
Casari, A., Schiavone, M., Facchinello, N., Vettori, A., Meyer, D., Tiso, N., Moro, E., Argenton, F. (2014) A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development. Developmental Biology. 396(1):81-93
Kalogirou, S., Malissovas, N., Moro, E., Argenton, F., Stainier, D.Y., Beis, D. (2014) Intracardiac Flow Dynamics Regulate Atrioventricular Valve Morphogenesis. Cardiovascular research. 104(1):49-60
Kizil, C., Küchler, B., Yan, J.J., Özhan, G., Moro, E., Argenton, F., Brand, M., Weidinger, G., Antos, C.L. (2014) Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development (Cambridge, England). 141:3529-39
Cosimelli, B., Laneri, S., Ostacolo, C., Sacchi, A., Severi, E., Porcù, E., Rampazzo, E., Moro, E., Basso, G., Viola, G. (2014) Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling. European Journal of Medicinal Chemistry. 83C:45-56
Benato, F., Colletti, E., Skobo, T., Moro, E., Colombo, L., Argenton, F., Dalla Valle, L. (2014) A living biosensor model to dynamically trace glucocorticoid transcriptional activity during development and adult life in zebrafish. Molecular and Cellular Endocrinology. 392(1-2):60-72
Schiavone, M., Rampazzo, E., Casari, A., Battilana, G., Persano, L., Moro, E., Liu, S., Leach, S.D., Tiso, N., Argenton, F. (2014) Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Disease models & mechanisms. 7(7):883-94
Wehner, D., Cizelsky, W., Vasudevaro, M.D., Özhan, G., Haase, C., Kagermeier-Schenk, B., Röder, A., Dorsky, R.I., Moro, E., Argenton, F., Kühl, M., and Weidinger, G. (2014) Wnt/β-Catenin Signaling Defines Organizing Centers that Orchestrate Growth and Differentiation of the Regenerating Zebrafish Caudal Fin. Cell Reports. 6(3):467-481
Corallo, D., Schiavinato, A., Trapani, V., Moro, E., Argenton, F., and Bonaldo, P. (2013) Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals. Development (Cambridge, England). 140(22):4594-4601
Demir, K., Kirsch, N., Beretta, C.A., Erdmann, G., Ingelfinger, D., Moro, E., Argenton, F., Carl, M., Niehrs, C., and Boutros, M. (2013) RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Reports. 4(6):1224-1234
Moro, E., Vettori, A., Porazzi, P., Schiavone, M., Rampazzo, E., Casari, A., Ek, O., Facchinello, N., Astone, M., Zancan, I., Milanetto, M., Tiso, N., and Argenton, F. (2013) Generation and application of signaling pathway reporter lines in zebrafish. Molecular genetics and genomics : MGG. 288(5-6):231-242
Rampazzo, E., Persano, L., Pistollato, F., Moro, E., Frasson, C., Porazzi, P., Della Puppa, A., Bresolin, S., Battilana, G., Indraccolo, S., Te Kronnie, G., Argenton, F., Tiso, N., and Basso, G. (2013) Wnt activation promotes neuronal differentiation of Glioblastoma. Cell Death & Disease. 4:e500
Wang, X., Kopinke, D., Lin, J., McPherson, A.D., Duncan, R.N., Otsuna, H., Moro, E., Hoshijima, K., Grunwald, D.J., Argenton, F., Chien, C.B., Murtaugh, L.C., and Dorsky, R.I. (2012) Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Developmental Cell. 23(3):624-636
Hammond, C.L., and Moro, E. (2012) Using transgenic reporters to visualize bone and cartilage signaling during development in vivo. Frontiers in Experimental Endocrinology. 3:91
Dodge, M.E., Moon, J., Tuladhar, R., Lu, J., Jacob, L.S., Zhang, L.S., Shi, H., Wang, X., Moro, E., Mongera, A., Argenton, F., Karner, C.M., Carroll, T.J., Chen, C., Amatruda, J.F., and Lum, L. (2012) Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine. The Journal of biological chemistry. 287(27):23246-23254
Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R.M., Bournele, D., Domenichini, A., Valdivia, L.E., Lum, L., Chen, C., Amatruda, J.F., Tiso, N., Weidinger, G., and Argenton, F. (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Developmental Biology. 366(2):327-340
Valdivia, L.E., Young, R.M., Hawkins, T.A., Stickney, H.L., Cavodeassi, F., Schwarz, Q., Pullin, L.M., Villegas, R., Moro, E., Argenton, F., Allende, M.L., and Wilson, S.W. (2011) Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development. Development (Cambridge, England). 138(18):3931-3941
Vettori, A., Bergamin, G., Moro, E., Vazza, G., Polo, G., Tiso, N., Argenton, F., and Mostacciuolo, M.L. (2011) Developmental defects and neuromuscular alterations due to mitofusin 2 gene (MFN2) silencing in zebrafish: A new model for Charcot-Marie-Tooth type 2A neuropathy. Neuromuscular disorders : NMD. 21(1):58-67
Brennan, C., Dosch, R., Haramis, A.P., Luckenbacher, T., Martinez-Morales, J.R., Moro, E., Polok, B., Ramesh, T.M., Russell, C., Argenton, F., and Strähle, U. (2010) Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18-22, 2010. Zebrafish. 7(3):305-310
Ragvin, A., Moro, E., Fredman, D., Navratilova, P., Drivenes, O., Engström, P.G., Alonso, M.E., Mustienes, E.D., Gomez Skarmeta, J.L., Tavares, M.J., Casares, F., Manzanares, M., van Heyningen, V., Molven, A., Njølstad, P.R., Argenton, F., Lenhard, B., and Becker, T.S. (2010) Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proceedings of the National Academy of Sciences of the United States of America. 107(2):775-780
Moro, E., Tomanin, R., Friso, A., Modena, N., Tiso, N., Scarpa, M., and Argenton, F. (2010) A novel functional role of iduronate-2-sulfatase in zebrafish early development. Matrix biology : journal of the International Society for Matrix Biology. 29(1):43-50
Tiso, N., Moro, E., and Argenton, F. (2009) Zebrafish Pancreas Development. Molecular and Cellular Endocrinology. 312(1-2):24-30
Moro, E., Gnügge, L., Braghetta, P., Bortolussi, M., and Argenton, F. (2009) Analysis of beta cell proliferation dynamics in zebrafish. Developmental Biology. 332(2):299-308
Moro, E., Maran, C., Slongo, M.L., Argenton, F., Toppo, S., and Onisto, M. (2007) Zebrafish spata2 is expressed at early developmental stages. The International journal of developmental biology. 51(3):241-246