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Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-131003-1
Pei Lab, Research Center for Environment and Health (RCEH)
PI/Director: Pei, Desheng
Contact Person: Pei, Desheng
Email: peids@cigit.ac.cn
URL: http://english.cigit.cas.cn/department/ttgioee/rceh/201403/t20140326_118503.html
Address: Chongqing Insitute of Green and Intelligent Technology, Chinese Academy of Sciences No.266 Fangzheng Avenue, Shuitu Hi-tech Industrial Park, Shuitu Town, Beibei District, Chongqing 400714,China
Country: China
Phone: +862365935812
Fax: +862365935000
Line Designation: cig


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 10 genomic features


STATEMENT OF RESEARCH INTERESTS
Our research interests mainly focus on studying toxicological effects, mechanisms and ecological risk assessment of classic environmental pollutants by using zebrafish model. We are endeavoring to develop the aquatic real-time biological monitoring technologies, and explore the pathogenic mechanisms or carcinogenesis. Our final goal is to provide the theoretical bases and technical support for environmental protection and the potential therapies of the related human diseases.

Research directions:
1.Developing the real-time biological monitoring of environmental pollutants.
2.Evaluating the toxicity and hazard of environmental pollutants.
3.Optimizing biological engineering species to sensitize environmental pollutants.
4.Elucidating DNA damage mechanisms of potentially carcinogenic pollutants.


LAB MEMBERS
Jia, Panpan Graduate Student Junaid, Muhammad Graduate Student Liu, Yi Graduate Student
Lu, Chunjiao Graduate Student Luo, Juanjuan Graduate Student Tang, Yumei Graduate Student
Wang, Chao Graduate Student Wang, Wenzhi Graduate Student Xie, Shaolin Graduate Student
Zhang, Jinghui Graduate Student Zhao, Yuntao Graduate Student Bian, Wanping Research Staff
Chen, Yanling Research Staff Deng, Shun Research Staff Ma, Yanbo Research Staff
Nui, Aping Research Staff Zhang, Jianglin Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Junaid, M., Jia, P.P., Tang, Y.M., Xiong, W.X., Huang, H.Y., Strauss, P.R., Li, W.G., Pei, D.S. (2018) Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China. Environmental pollution (Barking, Essex : 1987). 242(Pt B):1939-1949
Liu, Y., Junaid, M., Wang, Y., Tang, Y.M., Bian, W.P., Xiong, W.X., Huang, H.Y., Chen, C.D., Pei, D.S. (2018) New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach. Aquatic toxicology (Amsterdam, Netherlands). 201:151-161
Deng, S., Jia, P.P., Zhang, J.H., Junaid, M., Niu, A., Ma, Y.B., Fu, A., Pei, D.S. (2018) Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs). Journal of hazardous materials. 357:146-158
Luo, J.J., Bian, W.P., Liu, Y., Huang, H.Y., Yin, Q., Yang, X.J., Pei, D.S. (2018) CRISPR/Cas9-based genome engineering of zebrafish using a seamless integration strategy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9):5132-5142
Ma, Y.B., Lu, C.J., Junaid, M., Jia, P.P., Yang, L., Zhang, J.H., Pei, D.S. (2018) Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish. Chemosphere. 207:320-328
Luo, J.J., Su, D.S., Xie, S.L., Liu, Y., Liu, P., Yang, X.J., Pei, D.S. (2018) Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5):2814-2826
Wang, C., Chen, Y.L., Bian, W.P., Xie, S.L., Qi, G.L., Liu, L., Strauss, P.R., Zou, J.X., Pei, D.S. (2017) Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish & shellfish immunology. 72:572-580
Ma, Y.B., Jia, P.P., Junaid, M., Yang, L., Lu, C.J., Pei, D.S. (2017) Reproductive effects linked to DNA methylation in male zebrafish chronically exposed to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate. Environmental pollution (Barking, Essex : 1987). 237:1050-1061
Xie, S.L., Junaid, M., Bian, W.P., Luo, J.J., Syed, J.H., Wang, C., Xiong, W.X., Ma, Y.B., Niu, A., Yang, X.J., Zou, J.X., Pei, D.S. (2017) Generation and application of a novel transgenic zebrafish line Tg(cyp1a:mCherry) as an in vivo assay to sensitively monitor PAHs and TCDD in the environment. Journal of hazardous materials. 344:723-732
Lu, C.J., Jiang, X.F., Junaid, M., Ma, Y.B., Jia, P.P., Wang, H.B., Pei, D.S. (2017) Graphene oxide nanosheets induce DNA damage and activate the base excision repair (BER) signaling pathway both in vitro and in vivo. Chemosphere. 184:795-805
Wu, X.D., Guo, T., Liu, L., Wang, C., Zhang, K., Liu, H.Q., Wang, F., Bai, W.D., Zhang, M.Y. (2017) MiR-23a targets RUNX2 and suppresses ginsenoside Rg1-induced angiogenesis in endothelial cells. Oncotarget. 8:58072-58085
Zhang, J.H., Sun, T., Niu, A., Tang, Y.M., Deng, S., Luo, W., Xu, Q., Wei, D., Pei, D.S. (2017) Perturbation effect of reduced graphene oxide quantum dots (rGOQDs) on aryl hydrocarbon receptor (AhR) pathway in zebrafish. Biomaterials. 133:49-59
Tang, Y.M., Junaid, M., Niu, A., Deng, S., Pei, D.S. (2017) Diverse toxicological risks of PAHs in surface water with an impounding level of 175m in the Three Gorges Reservoir Area, China. The Science of the total environment. 580:1085-1096
Li, J., Niu, A., Lu, C.J., Zhang, J.H., Junaid, M., Strauss, P.R., Xiao, P., Wang, X., Ren, Y.W., Pei, D.S. (2017) A novel forward osmosis system in landfill leachate treatment for removing polycyclic aromatic hydrocarbons and for direct fertigation. Chemosphere. 168:112-121
He, X., Gao, J., Dong, T., Chen, M., Zhou, K., Chang, C., Luo, J., Wang, C., Wang, S., Chen, D., Zhou, Z., Tian, Y., Xia, Y., Wang, X. (2016) Developmental Neurotoxicity of Methamidophos in the Embryo-Larval Stages of Zebrafish. International Journal of Environmental Research and Public Health. 14(1)
Zhang, J.H., Niu, A., Li, J., Fu, J.W., Xu, Q., Pei, D.S. (2016) In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish. Scientific Reports. 6:37860
Dong, B., Song, X., Kong, X., Wang, C., Tang, Y., Liu, Y., Lin, W. (2016) Simultaneous Near-Infrared and Two-Photon In Vivo Imaging of H2 O2 Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of Oxonium.. Advanced materials (Deerfield Beach, Fla.). 28(39):8755-8759
Xie, S.L., Bian, W.P., Wang, C., Junaid, M., Zou, J.X., Pei, D.S. (2016) A novel technique based on in vitro oocyte injection to improve CRISPR/Cas9 gene editing in zebrafish. Scientific Reports. 6:34555
Niu, A., Ren, Y.W., Yang, L., Xie, S.L., Jia, P.P., Zhang, J.H., Wang, X., Li, J., Pei, D.S. (2016) Toxicological characterization of a novel wastewater treatment process using EDTA-Na2Zn as draw solution (DS) for the efficient treatment of MBR-treated landfill leachate. Chemosphere. 155:100-108
Jia, P.P., Ma, Y.B., Lu, C.J., Mirza, Z., Zhang, W., Jia, Y.F., Li, W.G., Pei, D.S. (2016) The Effects of Disturbance on Hypothalamus-Pituitary-Thyroid (HPT) Axis in Zebrafish Larvae after Exposure to DEHP. PLoS One. 11:e0155762
Ding, H., Wang, C., Huang, K., Machiraju, R. (2015) GRAPHIE: graph based histology image explorer. BMC Bioinformatics. 16 Suppl 11:S10
Wu, G., Diaz, A.K., Paugh, B.S., Rankin, S.L., Ju, B., Li, Y., Zhu, X., Qu, C., Chen, X., Zhang, J., Easton, J., Edmonson, M., Ma, X., Lu, C., Nagahawatte, P., Hedlund, E., Rusch, M., Pounds, S., Lin, T., Onar-Thomas, A., Huether, R., Kriwacki, R., Parker, M., Gupta, P., Becksfort, J., Wei, L., Mulder, H.L., Boggs, K., Vadodaria, B., Yergeau, D., Russell, J.C., Ochoa, K., Fulton, R.S., Fulton, L.L., Jones, C., Boop, F.A., Broniscer, A., Wetmore, C., Gajjar, A., Ding, L., Mardis, E.R., Wilson, R.K., Taylor, M.R., Downing, J.R., Ellison, D.W., Zhang, J., Baker, S.J. (2014) The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nature Genetics. 46:444-50
Dai, Y.J., Jia, Y.F., Chen, N., Bian, W.P., Li, Q.K., Ma, Y.B., Chen, Y.L., and Pei, D.S. (2014) Zebrafish as a model system to study toxicology. Environmental toxicology and chemistry. 33(1):11-17
Pei, D., Luther, W., Wang, W., Paw, B.H., Stewart, R.A., and George, R.E. (2013) Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models. PLoS Genetics. 9(6):e1003533
Pei, D.S., and Strauss, P.R. (2013) Zebrafish as a model system to study DNA damage and repair. Mutation research. 743-744:151-9
Chen, Y., Wu, B., Xu, L., Li, H., Xia, J., Yin, W., Li, Z., Li, S., Lin, S., Shu, X., and Pei, D. (2012) A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Research. 22(2):333-345
Ma, Y., Han, J., Guo, Y., Lam, P.K., Wu, R.S., Giesy, J.P., Zhang, X., and Zhou, B. (2012) Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol. Aquatic toxicology (Amsterdam, Netherlands). 106-107:173-181
Pei, D.S., Yang, X.J., Liu, W., Guikema, J.E., Schrader, C.E., and Strauss, P.R. (2011) A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic acids research. 39(8):3156-3165
Chen, C.H., Sun, Y.H., Pei, D.S., and Zhu, Z.Y. (2009) Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements. Developmental dynamics : an official publication of the American Association of Anatomists. 238(11):2850-2859
Pei, D.S., Sun, Y.H., and Zhu, Z.Y. (2009) Identification of a novel gene K23 over-expressed in fish cross-subfamily cloned embryos. Molecular biology reports. 36(6):1375-1380
Liu, J., Sun, Y.H., Wang, Y.W., Wang, N., Pei, D.S., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology. 70(9):1525-1535
Pei, D.S., Sun, Y.H., Long, Y., and Zhu, Z.Y. (2008) Inhibition of no tail (ntl) gene expression in zebrafish by external guide sequence (EGS) technique. Molecular biology reports. 35(2):139-143
Pei, D.S., Sun, Y.H., Chen, C.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Developmental Biology. 8:29
Pei, D.S., Sun, Y.H., and Zhu, Z.Y. (2008) Construction of cytoplasmic molecular markers distinguishing Danio rerio from Gobiocypris rarus at high identity domains based on MP-PCR strategy and Sybr Green I detection. Molecular biology reports. 35(1):45-50
Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Identification of differentially expressed genes from the cross-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology. 68(9):1282-1291
Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Analytical biochemistry. 363(2):291-293