ZFIN ID: ZDB-LAB-130212-1
Costagliola Lab
PI/Director: Costagliola, Sabine
Contact Person: Janssens, Véronique
Email: ve.janssens@gmail.com
URL: http://costalab.ulb.ac.be
Address: IRIBHM, ULB, building C, Level 6, local 136 808 route de Lennik 1070 Brussels, Belgium
Country: Belgium
Phone: +32 2555 41 97
Fax: +32 2 555 46 55
Line Designation: ulb


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 3 genomic features


STATEMENT OF RESEARCH INTERESTS
The main research focus of our team is the molecular dissection of the signaling mechanisms that control morphogenetic processes and gene networks involved in Thyroid Organogenesis. To date, the signaling mechanisms that control the specification of endoderm-derived organs such as the thyroid, lung, liver or pancreas remain poorly understood. To tackle the question "how different cell types are specified from the gut endoderm?", we use the thyroid as experimental model.Thyroid organogenesis can be grossly divided into 3 phases comprising (a) thyroid precursor cell specification, (b) budding and migration of the thyroid primordium, and (c) functional differentiation of thyroid follicular cells. While some factors critical for migration, differentiation and growth of the thyroid primordium have been identified in mouse knock-out models, little is known about the molecular events involved in thyroid precursors cell specification. A crucial aspect of our working strategy is the combination of various experimental models including mouse, Zébrafish and stem cells to delineate the molecular basis of thyroid morphogenesis.


LAB MEMBERS
Opitz, Robert Post-Doc Trubiroha, Achim Post-Doc Antonica, Francesco Graduate Student
Ballot, Celine Graduate Student Figini, Dominika Graduate Student Vandernoot, Isabelle Graduate Student
Janssens, Véronique Administrative Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Duerinckx, S., Jacquemin, V., Drunat, S., Vial, Y., Passemard, S., Perazzolo, C., Massart, A., Soblet, J., Racapé, J., Desmyter, L., Badoer, C., Papadimitriou, S., Borgne, Y.L., Lefort, A., Libert, F., Maertelaer, V., Rooman, M., Costagliola, S., Verloes, A., Lenaerts, T., Pirson, I., Abramowicz, M. (2019) Digenic inheritance of human primary microcephaly delineates centrosomal and non centrosomal pathways. Human Mutation. 41(2):512-524
Giusti, N., Gillotay, P., Trubiroha, A., Opitz, R., Dumont, J.E., Costagliola, S., De Deken, X. (2019) Inhibition of the thyroid hormonogenic H2O2 production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound. Molecular and Cellular Endocrinology. 500:110635
Trubiroha, A., Gillotay, P., Giusti, N., Gacquer, D., Libert, F., Lefort, A., Haerlingen, B., De Deken, X., Opitz, R., Costagliola, S. (2018) A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Scientific Reports. 8:5647
Opitz, R., Hitz, M.P., Vandernoot, I., Trubiroha, A., Abu-Khudir, R., Samuels, M., Désilets, V., Costagliola, S., Andelfinger, G., Deladoëy, J. (2015) Functional Zebrafish Studies Based on Human Genotyping Point to Netrin-1 as a Link Between Aberrant Cardiovascular Development and Thyroid Dysgenesis. Endocrinology. 1(1):377-88
Opitz, R., Antonica, F., Costagliola, S. (2013) New Model Systems to Illuminate Thyroid Organogenesis. Part I: An Update on the Zebrafish Toolbox. European thyroid journal. 2:229-242
Opitz, R., Maquet, E., Zoenen, M., Dadhich, R., and Costagliola, S. (2011) TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish. Molecular endocrinology (Baltimore, Md.). 25(9):1579-99