ZFIN ID: ZDB-LAB-130104-1
Clements Lab
PI/Director: Clements, Wilson
Contact Person: Clements, Wilson
Email: wilson.clements@stjude.org
URL: http://www.stjude.org/clements
Address: Dept. of Hematology Division of Experimental Hematology St Jude Children's Research Hospital 262 Danny Thomas Pl Memphis, TN
Country: United States
Phone: 901-595-5940
Fax: 901-595-4723
Line Designation: sj


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 3 genomic features


STATEMENT OF RESEARCH INTERESTS
The laboratory focuses on understanding the developmental specification of hematopoietic stem cells and vascular smooth muscle cells. We are also interested in understanding the molecular basis of specific B cell leukemias, and the connection of these mechanisms to developmental programming.


LAB MEMBERS
Genthe, Jamie Post-Doc Glenn, Nikki Post-Doc Kelley, Clair Research Staff
Mangum, Spencer


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Glenn, N.O., Henry, C.A. (2019) How muscle contraction strengthens tendons. eLIFE. 8
Genthe, J.R., Min, J., Farmer, D.M., Shelat, A.A., Grenet, J.A., Lin, W., Finkelstein, D.B., Vrijens, K., Chen, T., Guy, R.K., Clements, W.K., Roussel, M.F. (2017) Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. ACS Chemical Biology. 12(9):2436-2447
Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467
Genthe, J.R., Clements, W.K. (2017) R-spondin-1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways. Development (Cambridge, England). 144(4):590-600
Lee, Y., Manegold, J.E., Kim, A.D., Pouget, C., Stachura, D.L., Clements, W.K., Traver, D. (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nature communications. 5:5583
Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G., Traver, D. (2014) Discrete Notch signaling requirements in the specification of hematopoietic stem cells. The EMBO journal. 33(20):2363-73
Glenn, N.O., Schumacher, J.A., Kim, H.J., Zhao, E.J., Skerniskyte, J., Sumanas, S. (2014) Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish. Developmental Biology. 393(1):149-59
Glenn, N.O., McKane, M., Kohli, V., Wen, K.K., Rubenstein, P.A., Bartmanm, T., and Sumanas, S. (2012) The W-Loop of Alpha-Cardiac Actin Is Critical for Heart Function and Endocardial Cushion Morphogenesis in Zebrafish. Molecular and cellular biology. 32(17):3527-3540
Clements, W.K., and Traver, D. (2012) Fish pharming: zebrafish antileukemia screening. Blood. 119(24):5614-5615
Clements, W.K., Kim, A.D., Ong, K.G., Moore, J.C., Lawson, N.D., and Traver, D. (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 474(7350):220-224
Clements, W.K., Ong, K.G., and Traver, D. (2009) Zebrafish wnt3 is expressed in developing neural tissue. Developmental dynamics : an official publication of the American Association of Anatomists. 238(7):1788-1795
Clements, W.K., and Kimelman, D. (2005) LZIC regulates neuronal survival during zebrafish development. Developmental Biology. 283(2):322-334