ZFIN Lab: Clements Lab

ZFIN ID: ZDB-LAB-130104-1

ZFIN ID: ZDB-LAB-130104-1

Clements Lab

PI/Director:	Clements, Wilson
Contact Person:	Clements, Wilson
Email:	wilson.clements@stjude.org
URL:	http://www.stjude.org/clements
Address:	Dept. of Hematology Division of Experimental Hematology St Jude Children's Research Hospital 262 Danny Thomas Pl Memphis, TN
Country:	United States
Phone:	901-595-5940
Fax:	901-595-4723
Line Designation:	sj

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 3 genomic features

STATEMENT OF RESEARCH INTERESTS

The laboratory focuses on understanding the developmental specification of hematopoietic stem cells and vascular smooth muscle cells. We are also interested in understanding the molecular basis of specific B cell leukemias, and the connection of these mechanisms to developmental programming.

LAB MEMBERS

Coffey, Elizabeth Post-Doc	Williamson, McLean Graduate Student	Kelley, Clair Research Staff
Simpson, Dana

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Rothschild, S.C., Lai, G., Tombes, R.M., Clements, W.K. (2023) Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish. PLoS Genetics. 19:e1011102e1011102

Coffey, E.C., Astumian, M., Alrowaished, S.S., Schaffer, C., Henry, C.A. (2021) Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. Journal of developmental biology. 9(4):

Koirala, S., Klein, J., Zheng, Y., Glenn, N.O., Eisemann, T., Fon Tacer, K., Miller, D.J., Kulak, O., Lu, M., Finkelstein, D.B., Neale, G., Tillman, H., Vogel, P., Strand, D.W., Lum, L., Brautigam, C.A., Pascal, J.M., Clements, W.K., Potts, P.R. (2020) Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase. Cell Reports. 32:107922

da Bandeira, D.S., Clements, W.K. (2020) MYC'xing it up: zebrafish B ALL models provide insight into MYC-driven disease and relapse. Oncotarget. 11:2372-2374

Genthe, J.R., Min, J., Farmer, D.M., Shelat, A.A., Grenet, J.A., Lin, W., Finkelstein, D.B., Vrijens, K., Chen, T., Guy, R.K., Clements, W.K., Roussel, M.F. (2017) Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. ACS Chemical Biology. 12(9):2436-2447

Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467

Genthe, J.R., Clements, W.K. (2017) R-spondin-1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways. Development (Cambridge, England). 144(4):590-600

Lee, Y., Manegold, J.E., Kim, A.D., Pouget, C., Stachura, D.L., Clements, W.K., Traver, D. (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nature communications. 5:5583

Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G., Traver, D. (2014) Discrete Notch signaling requirements in the specification of hematopoietic stem cells. The EMBO journal. 33(20):2363-73

Clements, W.K., and Traver, D. (2012) Fish pharming: zebrafish antileukemia screening. Blood. 119(24):5614-5615

Clements, W.K., Kim, A.D., Ong, K.G., Moore, J.C., Lawson, N.D., and Traver, D. (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 474(7350):220-224

Clements, W.K., Ong, K.G., and Traver, D. (2009) Zebrafish wnt3 is expressed in developing neural tissue. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1788-1795

Clements, W.K., and Kimelman, D. (2005) LZIC regulates neuronal survival during zebrafish development. Developmental Biology. 283(2):322-334