ZFIN ID: ZDB-LAB-121205-1
Mercader Lab
PI/Director: Mercader Huber, Nadia
Contact Person: Mercader Huber, Nadia
Email: nmercader@cnic.es
URL: http://www.cnic.es/en/desarrollo/pezcebra/index.php
Address: Departament of Cardiovascular Development and Repair Centro Nacional de Investigaciones Cardiovasculares CNIC calle Melchor Fernandez Almagro 3 28029 Madrid
Country: Spain
Phone: + 34 4531200 ext 3105
Fax: + 34 4531
Line Designation: brn


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 24 genomic features


STATEMENT OF RESEARCH INTERESTS
Development of the epicardium and its role during regeneration


LAB MEMBERS
Gonzalez-Rosa, Juan Manuel Graduate Student Sánchez Iranzo, Héctor Graduate Student Marques, Ines Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Rodius, S., de Klein, N., Jeanty, C., Sánchez-Iranzo, H., Crespo, I., Ibberson, M., Xenarios, I., Dittmar, G., Mercader, N., Niclou, S.P., Azuaje, F. (2020) Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity. Scientific Reports. 10:2896
Bensimon-Brito, A., Ramkumar, S., Boezio, G.L.M., Guenther, S., Kuenne, C., Helker, C.S.M., Sánchez-Iranzo, H., Iloska, D., Piesker, J., Pullamsetti, S., Mercader, N., Beis, D., Stainier, D.Y.R. (2019) TGF-β Signaling Promotes Tissue Formation during Cardiac Valve Regeneration in Adult Zebrafish. Developmental Cell. 52(1):9-20.e7
Sande-Melón, M., Marques, I.J., Galardi-Castilla, M., Langa, X., Pérez-López, M., Botos, M.A., Sánchez-Iranzo, H., Guzmán-Martínez, G., Ferreira Francisco, D.M., Pavlinic, D., Benes, V., Bruggmann, R., Mercader, N. (2019) Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish. Cell Reports. 29:1041-1054.e5
Marques, I.J., Lupi, E., Mercader, N. (2019) Model systems for regeneration: zebrafish. Development (Cambridge, England). 146(18)
Sanz-Morejón, A., García-Redondo, A.B., Reuter, H., Marques, I.J., Bates, T., Galardi-Castilla, M., Große, A., Manig, S., Langa, X., Ernst, A., Piragyte, I., Botos, M.A., González-Rosa, J.M., Ruiz-Ortega, M., Briones, A.M., Salaices, M., Englert, C., Mercader, N. (2019) Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish. Cell Reports. 28:1296-1306.e6
Andrés-Delgado, L., Ernst, A., Galardi-Castilla, M., Bazaga, D., Peralta, M., Münch, J., González-Rosa, J.M., Marques, I., Tessadori, F., de la Pompa, J.L., Vermot, J., Mercader, N. (2019) Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells. Development (Cambridge, England). 146(13):
Conedera, F.M., Pousa, A.M.Q., Mercader, N., Tschopp, M., Enzmann, V. (2019) Retinal microglia signaling affects Müller cell behavior in the zebrafish following laser injury induction. Glia. 67(6):1150-1166
Rovira, M., Borràs, D.M., Marques, I.J., Puig, C., Planas, J.V. (2018) Physiological Responses to Swimming-Induced Exercise in the Adult Zebrafish Regenerating Heart. Frontiers in Physiology. 9:1362
Guner-Ataman, B., González-Rosa, J.M., Shah, H.N., Butty, V.L., Jeffrey, S., Abrial, M., Boyer, L.A., Burns, C.G., Burns, C.E. (2018) Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome. Cell Reports. 24:1342-1354.e5
Sánchez-Iranzo, H., Galardi-Castilla, M., Sanz-Morejón, A., González-Rosa, J.M., Costa, R., Ernst, A., Sainz de Aja, J., Langa, X., Mercader, N. (2018) Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart. Proceedings of the National Academy of Sciences of the United States of America. 115(16):4188-4193
Sánchez-Iranzo, H., Galardi-Castilla, M., Minguillón, C., Sanz-Morejón, A., González-Rosa, J.M., Felker, A., Ernst, A., Guzmán-Martínez, G., Mosimann, C., Mercader, N. (2018) Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nature communications. 9:428
Natarajan, N., Abbas, Y., Bryant, D.M., Gonzalez-Rosa, J.M., Sharpe, M., Uygur, A., Cocco-Delgado, L.H., Ho, N.N., Gerard, N.P., Gerard, C.J., Macrae, C.A., Burns, C.E., Burns, C.G., Whited, J.L., Lee, R.T. (2018) Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 137(20):2152-2165
Mercader, N., Serras, F. (2018) Can broken hearts be mended? Ken Poss, a pioneer on heart regeneration research. The International journal of developmental biology. 62:383-386
González-Rosa, J.M., Burns, C.E., Burns, C.G. (2017) Zebrafish heart regeneration: 15 years of discoveries. Regeneration (Oxford, England). 4:105-123
Awasthi Mishra, N., Drögemüller, C., Jagannathan, V., Keller, I., Wüthrich, D., Bruggmann, R., Beck, J., Schütz, E., Brenig, B., Demmel, S., Moser, S., Signer-Hasler, H., Pieńkowska-Schelling, A., Schelling, C., Sande, M., Rongen, R., Rieder, S., Kelsh, R.N., Mercader, N., Leeb, T. (2017) A structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle. PLoS One. 12:e0180170
Vazão, H., Rosa, S., Barata, T., Costa, R., Pitrez, P.R., Honório, I., de Vries, M.R., Papatsenko, D., Benedito, R., Saris, D., Khademhosseini, A., Quax, P.H., Pereira, C.F., Mercader, N., Fernandes, H., Ferreira, L. (2017) High-throughput identification of small molecules that affect human embryonic vascular development. Proceedings of the National Academy of Sciences of the United States of America. 114(15):E3022-E3031
Kappel, S., Marques, I.J., Zoni, E., Stokłosa, P., Peinelt, C., Mercader, N., Kruithof-de Julio, M., Borgström, A. (2017) Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives.. Current molecular biology reports. 3:208-217
Manalo, T., May, A., Quinn, J., Lafontant, D.S., Shifatu, O., He, W., Gonzalez-Rosa, J.M., Burns, G.C., Burns, C.E., Burns, A.R., Lafontant, P.J. (2016) Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio (Devario aequipinnatus) and Zebrafish (Danio rerio) Hearts. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 64(11):687-714
Andrés-Delgado, L., Mercader, N. (2016) Interplay between cardiac function and heart development. Biochimica et biophysica acta. Molecular cell research. 1863(7 Pt B):1707-16
Rodius, S., Androsova, G., Götz, L., Liechti, R., Crespo, I., Merz, S., Nazarov, P.V., de Klein, N., Jeanty, C., González-Rosa, J.M., Muller, A., Bernardin, F., Niclou, S.P., Vallar, L., Mercader, N., Ibberson, M., Xenarios, I., Azuaje, F. (2016) Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Scientific Reports. 6:26822
Di Donato, V., De Santis, F., Auer, T., Testa, N., Sánchez-Iranzo, H., Mercader, N., Concordet, J.P., Del Bene, F. (2016) 2C-Cas9: a versatile tool for clonal analysis of gene function. Genome research. 26(5):681-92
Bednarek, D., González-Rosa, J.M., Guzmán-Martínez, G., Gutiérrez-Gutiérrez, Ó., Aguado, T., Sánchez-Ferrer, C., Marques, I.J., Galardi-Castilla, M., de Diego, I., Gómez, M.J., Cortés, A., Zapata, A., Jiménez-Borreguero, L.J., Mercader, N., Flores, I. (2015) Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Reports. 12(10):1691-703
González-Rosa, J.M., Guzmán-Martínez, G., Marques, I.J., Sánchez-Iranzo, H., Jiménez-Borreguero, L.J., Mercader, N. (2014) Use of Echocardiography Reveals Reestablishment of Ventricular Pumping Efficiency and Partial Ventricular Wall Motion Recovery upon Ventricular Cryoinjury in the Zebrafish. PLoS One. 9:e115604
Rodius, S., Nazarov, P.V., Nepomuceno-Chamorro, I.A., Jeanty, C., González-Rosa, J.M., Ibberson, M., da Costa, R.M., Xenarios, I., Mercader, N., Azuaje, F. (2014) Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. BMC Genomics. 15:852
Peralta, M., González-Rosa, J.M., Marques, I.J., Mercader, N. (2014) The Epicardium in the Embryonic and Adult Zebrafish. Journal of developmental biology. 2:101-116
Peralta, M., Steed, E., Harlepp, S., González-Rosa, J.M., Monduc, F., Ariza-Cosano, A., Cortés, A., Rayón, T., Gómez-Skarmeta, J.L., Zapata, A., Vermot, J., and Mercader, N. (2013) Heartbeat-Driven Pericardiac Fluid Forces Contribute to Epicardium Morphogenesis. Current biology : CB. 23(18):1726-35
Cavodeassi, F., Bene, F.D., Fürthauer, M., Grabher, C., Herzog, W., Lehtonen, S., Linker, C., Mercader, N., Mikut, R., Norton, W., Strähle, U., Tiso, N., and Foulkes, N.S. (2013) Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21-24, 2012. Zebrafish. 10(1):119-23
Annila, T., Lihavainen, E., Marques, I.J., Williams, D.R., Yli-Harja, O., and Ribeiro, A. (2013) ZebIAT, an image analysis tool for registering zebrafish embryos and quantifying cancer metastasis. BMC Bioinformatics. 14(10):S5