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ZFIN ID: ZDB-LAB-110914-1 |
GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS
1. Molecular mechanism of intestinal metaplasia in the esophagus (Barrett's esophagus) and chemoprevention of esophageal adenocarcinoma: The goal of this project is to study the roles of gastroesophageal refluxate (acid and bile acids), genetic and epigenetic pathways in the development of Barrett's esophagus, the premalignant lesion of esophageal adenocarcinoma, in cell culture, animal models, and humans. Current studies focus on three areas: (1) How a group of squamous and intestinal transcription factors contribute to intestinal metaplasia in cell culture, surgical models (rats, mice, pigs) and genetically models (zebrafish, pigs). (2) How genetic factors and gene-environment interactions may contribute to racial disparity of Barrett's esophagus, e.g., why Caucasian Americans are more susceptible to Barrett's esophagus than African Amercians. (3) What molecular pathways may regulate resistance properties of esophageal squamous epithelium in the presence of gastroesophageal reflux.
2. Molecular mechanism and chemoprevention of alcohol and tobacco-associated oral cancer: We focus on aberrant arachidonic acid metabolism (especially the 5-lipoxygenase pathway) and oxidative damage in oral carcinogenesis of carcinogen-induced models in hamsters and mice. Both pharmacological (pharmaceutical and dietary agents) and genetic approaches are employed to elucidate the mechanism of oral carcinogenesis and design mechanism-based chemopreventive strategies. Potential candidate agents are further tested in human clinical trials.
LAB MEMBERS
ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
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Filiano, A.J., Xu, Y., Tustison, N.J., Marsh, R.L., Baker, W., Smirnov, I., Overall, C.C., Gadani, S.P., Turner, S.D., Weng, Z., Peerzade, S.N., Chen, H., Lee, K.S., Scott, M.M., Beenhakker, M.P., Litvak, V., Kipnis, J. (2016) Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature. 535:425-9
Zhang, Y., Zhang, Y., Chen, A., Zhang, W., Chen, H., Zhang, Q. (2016) Enantioselectivity in Developmental Toxicity of rac-metalaxyl and R-metalaxyl in Zebrafish (Danio rerio) Embryo. Chirality. 28(6):489-94
Zhu, Y., Wang, P., Zhao, Y., Yang, C., Clark, A., Leung, T., Chen, X., Sang, S. (2016) Synthesis, Evaluation, and Metabolism of Novel [6]-Shogaol Derivatives as Potent Nrf2 Activators. Free radical biology & medicine. 95:243-54
Zhang, C., Frazier, J.M., Chen, H., Liu, Y., Lee, J.A., Cole, G.J. (2014) Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages. Neurotoxicology and teratology. 44:70-80
Chen, W., Zhang, L., Zheng, G., Fu, Y., Ji, Q., Liu, F., Chen, H., He, C. (2014) Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS letters. 588:892-8
Hu, B., Chen, H., Liu, X., Zhang, C., Cole, G.J., Lee, J.A., and Chen, X. (2013) Transgenic Overexpression of cdx1b Induces Metaplastic Changes of Gene Expression in Zebrafish Esophageal Squamous Epithelium. Zebrafish. 10(2):218-227
Li, Q., Zhou, X., Guo, Y., Shang, X., Chen, H., Lu, H., Cheng, H., and Zhou, R. (2008) Nuclear localization, DNA binding and restricted expression in neural and germ cells of zebrafish Dmrt3. Biology of the cell. 100(8):453-463
Xu, H., Yang, J., Wang, Y., Jiang, Q., Chen, H., and Song, H. (2008) Exposure to 17α-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 88(1):1-8
Zhou, X., Li, Q., Lu, H., Chen, H., Guo, Y., Cheng, H., and Zhou, R. (2008) Fish specific duplication of Dmrt2: Characterization of zebrafish Dmrt2b. Biochimie. 90(6):878-887
