ZFIN ID: ZDB-LAB-101214-1
Hammond Lab
PI/Director: Hammond, Chrissy
Contact Person: Hammond, Chrissy
Email: chrissy.hammond@bristol.ac.uk
URL: http://www.bris.ac.uk/phys-pharm/research/staffresearch/chrissyhammond.html
Address: Departments of Biochemistry / Physiology and Pharmacology Medical Sciences, University of Bristol University Walk, Clifton, BS8 1TD
Country: United Kingdom
Phone: +44 0117 33 12228
Fax:
Line Designation: bsl


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 1 genomic features


STATEMENT OF RESEARCH INTERESTS
The lab works on the zebrafish skeletal system. We're particularly interested in cartilage and bone homeostasis, and how the properties of the cartilage matrix affect osteoblast differentiation. We are using the zebrafish as a model for osteoarthritis, a joint disease which affects tens of millions of people worldwide, looking at the underlying genetic casuses and how these impact on joint homeostasis.


LAB MEMBERS
Roddy, Karen Post-Doc Bergen, Dylan Graduate Student Brunt, Lucy Graduate Student
Reynolds, Scott Graduate Student Norton, Jo Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Newham, E., Kague, E., Aggleton, J.A., Fernee, C., Brown, K.R., Hammond, C.L. (2019) Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines. Journal of the Royal Society, Interface. 16:20190430
Gregson, C.L., Bergen, D., Leo, P., Sessions, R.B., Wheeler, L., Hartley, A., Youlten, S., Croucher, P.I., McInerney-Leo, A.M., Fraser, W., Tang, J.C.Y., Anderson, L., Marshall, M., Sergot, L., Paternoster, L., Davey-Smith, G., AOGC Consortium, Brown, M.A., Hammond, C., Kemp, J.P., Tobias, J.H., Duncan, E.L. (2019) A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 35(1):92-105
Kague, E., Hughes, S.M., A Lawrence, E., Cross, S., Martin-Silverstone, E., Hammond, C.L., Hinits, Y. (2019) Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(8):9116-9130
Bergen, D.J.M., Kague, E., Hammond, C.L. (2019) Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds. Frontiers in endocrinology. 10:6
Lawrence, E.A., Kague, E., Aggleton, J.A., Harniman, R.L., Roddy, K.A., Hammond, C.L. (2018) The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1759)
Stevenson, N.L., Bergen, D.J.M., Xu, A., Wyatt, E., Henry, F., McCaughey, J., Vuolo, L., Hammond, C.L., Stephens, D.J. (2018) Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control. Journal of Cell Science. 131(9)
Kague, E., Witten, P.E., Soenens, M., Campos, C.L., Lubiana, T., Fisher, S., Hammond, C., Brown, K.R., Passos-Bueno, M.R., Huysseune, A. (2018) Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth. Developmental Biology. 435(2):176-184
Stevenson, N.L., Bergen, D.J.M., Skinner, R.E.H., Kague, E., Martin-Silverstone, E., Robson Brown, K.A., Hammond, C.L., Stephens, D.J. (2017) Giantin knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression. Journal of Cell Science. 130(24):4132-4143
Brunt, L., Scholpp, S. (2017) The function of endocytosis in Wnt signaling.. Cellular and molecular life sciences : CMLS. 75(5):785-795
Bergen, D.J.M., Stevenson, N.L., Skinner, R.E.H., Stephens, D.J., Hammond, C.L. (2017) The Golgi matrix protein giantin is required for normal cilia function in zebrafish. Biology Open. 6(8):1180-1189
Brunt, L.H., Begg, K., Kague, E., Cross, S., Hammond, C.L. (2017) Wnt signalling controls the response to mechanical loading during Zebrafish joint development. Development (Cambridge, England). 144(15):2798-2809
Brunt, L.H., Roddy, K.A., Rayfield, E.J., Hammond, C.L. (2016) Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics. Journal of visualized experiments : JoVE. (118)
Brunt, L.H., Skinner, R.E., Roddy, K.A., Araujo, N.M., Rayfield, E.J., Hammond, C.L. (2016) Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis. Osteoarthritis and Cartilage. 24(11):1940-1950
Pipalia, T.G., Koth, J., Roy, S.D., Hammond, C.L., Kawakami, K., Hughes, S.M. (2016) Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair. Disease models & mechanisms. 9(6):671-84
Brunt, L. (2016) The role of biomechanics and signalling in zebrafish joint morphogenesis. Ph.D. Thesis.
Brunt, L.H., Norton, J.L., Bright, J.A., Rayfield, E.J., Hammond, C.L. (2015) Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development. Journal of biomechanics. 48(12):3112-22
Zancan, I., Bellesso, S., Costa, R., Salvalaio, M., Stroppiano, M., Hammond, C., Argenton, F., Filocamo, M., Moro, E. (2015) Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling. Human molecular genetics. 24(5):1280-94
Guiu, J., Bergen, D.J., De Pater, E., Islam, A.B., Ayllón, V., Gama-Norton, L., Ruiz-Herguido, C., González, J., López-Bigas, N., Menendez, P., Dzierzak, E., Espinosa, L., Bigas, A. (2014) Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. The Journal of experimental medicine. 211(12):2411-23
Williamson, R.C., Cowell, C.A., Hammond, C.L., Bergen, D., Roper, J., Feng, Y., Rendall, T.C., Race, P.R., Bass, M.D. (2014) Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. Journal of Cell Science. 127(Pt 19):4292-307
Hayes, A.J., Reynolds, S., Nowell, M.A., Meakin, L.B., Habicher, J., Ledin, J., Bashford, A., Caterson, B., and Hammond, C.L. (2013) Spinal Deformity in Aged Zebrafish Is Accompanied by Degenerative Changes to Their Vertebrae that Resemble Osteoarthritis. PLoS One. 8(9):e75787
Hayes, A.J., Mitchell, R.E., Bashford, A., Reynolds, S., Caterson, B., and Hammond, C.L. (2013) Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 242(6):778-89
Mitchell, R.E., Huitema, L.F., Skinner, R.H., Brunt, L.H., Severn, C., Schulte-Merker, S., and Hammond, C.L. (2013) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage. 21(2):269-278
Huitema, L.F., Apschner, A., Logister, I., Spoorendonk, K.M., Bussmann, J., Hammond, C.L., and Schulte-Merker, S. (2012) Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(52):21372-21377
Hammond, C.L., and Moro, E. (2012) Using transgenic reporters to visualize bone and cartilage signaling during development in vivo. Frontiers in Experimental Endocrinology. 3:91
Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011) Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin. Developmental Cell. 20(5):713-724
Spoorendonk, K. M., Hammond, C. L. , Huitema, L. F. A., Vanoevelen, J., Schulte-Merker, S. (2010) Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(2):219-224
Hammond, C.L., Hinits, Y., Osborn, D.P., Minchin, J.E., Tettamanti, G., and Hughes, S.M. (2007) Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish. Developmental Biology. 302(2):504-521
Groves, J.A., Hammond, C.L., and Hughes, S.M. (2005) Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development (Cambridge, England). 132(19):4211-4222