ZFIN ID: ZDB-LAB-100401-1
Epidermal Stem Cell Lab
PI/Director: Hsiao, Chung-Der
Contact Person: Hsiao, Chung-Der
Email: cdhsiao@yahoo.com.tw
URL: http://cdhsiao.weebly.com
Address: Epidermal Stem Cell Lab Department of Bioscience Technology Chung Yuan Christian Univ. 200, Chung Pei Rd. Chung-Li, 32023 Taiwan
Country: Taiwan
Phone: 886-3-2653545
Fax: 886-3-2653599
Line Designation: cy


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 25 genomic features


STATEMENT OF RESEARCH INTERESTS
1. Development of new genome editing tools of TALEN and CRISPR to manipulate fish genome
2. Development of Zebrafish model for human diseases (Obesity, aging and genetic disorders)
3. Development of new tools and zebrafsh models suitable to perform high throughput drug screening and behavioral assay
4. Development of bioinformatic pipeline to annotate aquatic animal’s transcriptome and decode genome


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Malhotra, N., Audira, G., Chen, J.R., Siregar, P., Hsu, H.S., Lee, J.S., Ger, T.R., Hsiao, C.D. (2020) Surface Modification of Magnetic Nanoparticles by Carbon-Coating Can Increase Its Biosafety: Evidences from Biochemical and Neurobehavioral Tests in Zebrafish. Molecules. 25(9):
Lin, Y.N., Audira, G., Malhotra, N., Ngoc Anh, N.T., Siregar, P., Lu, J.H., Lee, H., Hsiao, C.D. (2020) A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory. International Journal of Molecular Sciences. 21(8):
Bui Thi, N.H., Nguyen Thi, N.A., Audira, G., Siregar, P., Liang, S.T., Huang, J.C., Hsiao, C.D. (2020) Chronic Exposure to Low Concentration Lead Chloride-Induced Anxiety and Loss of Aggression and Memory in Zebrafish. International Journal of Molecular Sciences. 21(5):
Ngoc Hieu, B.T., Ngoc Anh, N.T., Audira, G., Juniardi, S., Liman, R.A.D., Villaflores, O.B., Lai, Y.H., Chen, J.R., Liang, S.T., Huang, J.C., Hsiao, C.D. (2020) Development of a Modified Three-Day T-maze Protocol for Evaluating Learning and Memory Capacity of Adult Zebrafish. International Journal of Molecular Sciences. 21(4):
Sarasamma, S., Audira, G., Siregar, P., Malhotra, N., Lai, Y.H., Liang, S.T., Chen, J.R., Chen, K.H., Hsiao, C.D. (2020) Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure. International Journal of Molecular Sciences. 21(4):
Li, X., Li, C., Zhu, Y., Shi, Y., Zhang, X., Zhang, S., Wang, L., Lin, H.W., Hou, H., Hsiao, C.D., Han, L., Liu, K. (2020) Lipids Fingerprinting of Different Materials Sources by UPLC-Q-Exactive Orbitrap/MS Approach and Their Zebrafish-based Activities Comparison. Journal of Agricultural and Food Chemistry. 68(7):2007-2015
Song, Z., Zhang, Y., Zhang, H., Rajendran, R.S., Wang, R., Hsiao, C.D., Li, J., Xia, Q., Liu, K. (2019) Isoliquiritigenin triggers developmental toxicity and oxidative stress-mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway. Chemosphere. 246:125727
Sarasamma, S., Audira, G., Samikannu, P., Juniardi, S., Siregar, P., Hao, E., Chen, J.R., Hsiao, C.D. (2019) Behavioral Impairments and Oxidative Stress in the Brain, Muscle, and Gill Caused by Chronic Exposure of C70 Nanoparticles on Adult Zebrafish. International Journal of Molecular Sciences. 20(22):
Liang, S.T., Chen, J.R., Tsai, J.J., Lai, Y.H., Hsiao, C.D. (2019) Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish. International Journal of Molecular Sciences. 20(15)
Huo, J., Yu, Q., Zhang, Y., Liu, K., Hsiao, C.D., Jiang, Z., Zhang, L. (2019) Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish. Journal of applied toxicology : JAT. 39(11):1532-1540
Zhang, Y., Cen, J., Jia, Z., Hsiao, C.D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L., Liu, K. (2019) Correction for Zhang et al., "Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish". Antimicrobial Agents and Chemotherapy. 63(7)
Audira, G., Sampurna, B.P., Juniardi, S., Liang, S.T., Lai, Y.H., Han, L., Hsiao, C.D. (2019) Establishing simple image-based methods and cost-effective instrument for toxicity assessment on circadian rhythm dysregulation in fish. Biology Open. 8(6):
Sampurna, B.P., Santoso, F., Lee, J.H., Yu, W.H., Wu, C.C., Audira, G., Juniardi, S., Chen, J.R., Lin, Y.T., Hsiao, C.D. (2019) Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish. Cells. 8(6)
Malhotra, N., Chen, J.R., Sarasamma, S., Audira, G., Siregar, P., Liang, S.T., Lai, Y.H., Lin, G.M., Ger, T.R., Hsiao, C.D. (2019) Ecotoxicity Assessment of Fe3O4 Magnetic Nanoparticle Exposure in Adult Zebrafish at an Environmental Pertinent Concentration by Behavioral and Biochemical Testing. Nanomaterials (Basel, Switzerland). 9(6):
Liang, S.T., Audira, G., Juniardi, S., Chen, J.R., Lai, Y.H., Du, Z.C., Lin, D.S., Hsiao, C.D. (2019) Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities. Cells. 8(5):
Jia, Z.L., Cen, J., Wang, J.B., Zhang, F., Xia, Q., Wang, X., Chen, X.Q., Wang, R.C., Hsiao, C.D., Liu, K.C., Zhang, Y. (2019) Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. 227:541-550
Zhang, Y., Cen, J., Jia, Z., Hsiao, C.D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L., Liu, K. (2019) Hepatotoxicity induced by Isoniazid/Lipopolysaccharide through ERS-, autophagy- and apoptosis pathway in zebrafish. Antimicrobial Agents and Chemotherapy. 63(5):
Audira, G., Sarasamma, S., Chen, J.R., Juniardi, S., Sampurna, B.P., Liang, S.T., Lai, Y.H., Lin, G.M., Hsieh, M.C., Hsiao, C.D. (2018) Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation. International Journal of Molecular Sciences. 19(12):
Jin, M., Xiao, Z., Zhang, S., Men, X., Li, X., Zhang, B., Zhou, T., Hsiao, C.D., Liu, K. (2018) Possible involvement of Fas/FasL-dependent apoptotic pathway in α-bisabolol induced cardiotoxicity in zebrafish embryos. Chemosphere. 219:557-566
Sarasamma, S., Lai, Y.H., Liang, S.T., Liu, K., Hsiao, C.D. (2018) The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities. International Journal of Molecular Sciences. 19(12)
Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Lai, Y.H., Hao, E., Chen, J.R., Hsiao, C.D. (2018) Evaluation of the Effects of Carbon 60 Nanoparticle Exposure to Adult Zebrafish: A Behavioral and Biochemical Approach to Elucidate the Mechanism of Toxicity. International Journal of Molecular Sciences. 19(12):
Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Liang, S.T., Hao, E., Lai, Y.H., Hsiao, C.D. (2018) Zinc Chloride Exposure Inhibits Brain Acetylcholine Levels, Produces Neurotoxic Signatures, and Diminishes Memory and Motor Activities in Adult Zebrafish. International Journal of Molecular Sciences. 19(10)
Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Liang, S.T., Hao, E., Lai, Y.H., and Hsiao, C.D. (2018) Zinc chloride exposure inhibits brain acetylcholine level and produces neurotoxic signatures and diminish memory and motor activities in adult zebrafish.. International Journal of Molecular Sciences. 19(10)
Xiong, X.Y., Liu, Y., Shan, L.T., Xu, Y.Q., Liang, J., Lai, Y.H., Hsiao, C.D. (2018) Evaluation of collagen mixture on promoting skin wound healing in zebrafish caused by acetic acid administration. Biochemical and Biophysical Research Communications. 505(2):516-522
Hsieh, F.C., Lu, Y.F., Liau, I., Chen, C.C., Cheng, C.M., Hsiao, C.D., Hwang, S.L. (2018) Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Scientific Reports. 8:7856
Sampurna, B.P., Audira, G., Juniardi, S., Lai, Y.H., and Hsiao, C.D. (2018) A Simple ImageJ-Based Method to Measure Cardiac Rhythm in Zebrafish Embryos. Inventions. 3(2)
Audira, G., Sampurna, B.P., Juniardi, S., Liang, S.T., Lai, Y.H., and Hsiao, C.D. (2018) A Simple Setup to Perform 3D Locomotion Tracking in Zebrafish by Using a Single Camera. Inventions. 3(1)
Schepis, A., Barker, A., Srinivasan, Y., Balouch, E., Zheng, Y., Lam, I., Clay, H., Hsiao, C.D., Coughlin, S.R. (2018) Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. The Journal of cell biology. 217(3):1097-1112
Chen, J.R., Lai, Y.H., Tsai, J.J., Hsiao, C.D. (2017) Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization. Molecules. 22(12)
Sarasamma, S., Varikkodan, M.M., Liang, S.T., Lin, Y.C., Wang, W.P., Hsiao, C.D. (2017) Zebrafish: A Premier Vertebrate Model for Biomedical Research in Indian Scenario. Zebrafish. 14(6):589-605
Zhang, Y., Han, L., He, Q., Chen, W., Sun, C., Wang, X., Chen, X., Wang, R., Hsiao, C.D., Liu, K. (2017) A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish. Journal of Pharmacological and Toxicological Methods. 84:102-110
Zhang, Y., Liu, K., Hassan, H.M., Guo, H., Ding, P., Han, L., He, Q., Chen, W., Hsiao, C.D., Zhang, L., Jiang, Z. (2016) L-FABP-deficiency provoked oxidative stress, inflammation and apoptosis-mediated hepatotoxicity induced by pyrazinamide on zebrafish larvae. Antimicrobial Agents and Chemotherapy. 60(12):7347-7356
Sun, G., Liu, K., Wang, X., Liu, X., He, Q., Hsiao, C.D. (2015) Identification and Expression Analysis of Zebrafish (Danio rerio) E-Selectin during Embryonic Development. Molecules. 20:18539-18550
Chang, T.Y., Huang, T.S., Wang, H.W., Chang, S.J., Lo, H.H., Chiu, Y.L., Wang, Y.L., Hsiao, C.D., Tsai, C.H., Chan, C.H., You, R.I., Wu, C.H., Tsai, T.N., Cheng, S.M., Cheng, C.C. (2014) miRNome traits analysis on endothelial lineage cells discloses biomarker potential circulating microRNAs which affect progenitor activities. BMC Genomics. 15:802
Huang, S.Y., Feng, C.W., Hung, H.C., Chakraborty, C., Chen, C.H., Chen, W.F., Jean, Y.H., Wang, H.M., Sung, C.S., Sun, Y.M., Wu, C.Y., Liu, W., Hsiao, C.D., Wen, Z.H. (2014) A Novel Zebrafish Model to Provide Mechanistic Insights into the Inflammatory Events in Carrageenan-Induced Abdominal Edema. PLoS One. 9:e104414
Chen, C.H., Lin, D.S., Cheng, C.W., Lin, C.J., Lo, Y.K., Yen, C.C., Lee, A.Y., Hsiao, C.D. (2014) Cdc6 cooperates with c-Myc to promote genome instability and EMT in zebrafish. Oncotarget. 5(15):6300-11
Feng, C.W., Wen, Z.H., Huang, S.Y., Hung, H.C., Chen, C.H., Yang, S.N., Chen, N.F., Wang, H.M., Hsiao, C.D., Chen, W.F. (2014) Effects of 6-Hydroxydopamine Exposure on Motor Activity and Biochemical Expression in Zebrafish (Danio Rerio) Larvae. Zebrafish. 11(3):227-39
Chen, S.Y., Shih, H.Y., Lin, S.J., Hsiao, C.D., Li, Z.C., and Cheng, Y.C. (2013) Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science. 126(Pt 24):5626-34
Shih, D.F., Hsiao, C.D., Min, M.Y., Lai, W.S., Yang, C.W., Lee, W.T., and Lee, S.J. (2013) Aromatic L-Amino Acid Decarboxylase (AADC) Is Crucial for Brain Development and Motor Functions. PLoS One. 8(8):e71741
Lin, C.Y., Huang, C.C., Wang, W.D., Hsiao, C.D., Cheng, C.F., Wu, Y.T., Lu, Y.F., and Hwang, S.P. (2013) Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One. 8(7):e69788
Chu, C.Y., Chen, C.F., Rajendran, R.S., Shen, C.N., Chen, T.H., Yen, C.C., Chuang, C.K., Lin, D.S., and Hsiao, C.D. (2012) Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7(5):e36474
Yeh, C.M., Liu, Y.C., Chang, C.J., Lai, S.L., Hsiao, C.D., and Lee, S.J. (2011) Ptenb Mediates Gastrulation Cell Movements via Cdc42/AKT1 in Zebrafish. PLoS One. 6(4):e18702
Chen, C.F., Chu, C.Y., Chen, T.H., Lee, S.J., Shen, C.N., and Hsiao, C.D. (2011) Establishment of a transgenic zebrafish line for superficial skin ablation and functional validation of apoptosis modulators in vivo. PLoS One. 6(5):e20654
Huang, S.H., Hsiao, C.D., Lin, D.S., Chow, C.Y., Chang, C.J., and Liau, I. (2011) Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. PLoS One. 6(9):e24764
Liu, D.W., Hsu, C.H., Tsai, S.M., Hsiao, C.D., and Wang, W.P. (2011) A variant of fibroblast growth factor receptor 2 (fgfr2) regulates left-right asymmetry in zebrafish. PLoS One. 6(7):e21793
Chang, W.J., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2009) The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(4):R1192-R1201
Tseng, D.Y., Chou, M.Y., Tseng, Y.C., Hsiao, C.D., Huang, C.J., Kaneko, T., and Hwang, P.P. (2009) Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. American journal of physiology. Regulatory, integrative and comparative physiology. 296(3):R549-R557
Chou, M.Y., Hsiao, C.D., Chen, S.C., Chen, I.W., Liu, S.T., and Hwang, P.P. (2008) Effects of hypothermia on gene expression in zebrafish gills: upregulation in differentiation and function of ionocytes as compensatory responses. The Journal of experimental biology. 211(Pt 19):3077-3084
Lin, T.Y., Liao, B.K., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2008) Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 294(5):C1250-C1260
Hsiao, C.D., You, M.S., Guh, Y.J., Ma, M., Jiang, Y.J., and Hwang, P.P. (2007) A Positive Regulatory Loop between foxi3a and foxi3b Is Essential for Specification and Differentiation of Zebrafish Epidermal Ionocytes. PLoS One. 2(1):e302
Hsiao, C.D., Ekker, M., and Tsai, H.J. (2003) Skin-specific expression of ictacalcin, a homolog of the S100 genes, during zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 228(4):745-750
Hsiao, C.-D. and Tsai, H.-J. (2003) Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivo. Developmental Biology. 262:313-323
Hsiao, C.-D., Tsai, W.-Y., Horng, L.-S., and Tsai, H.-J. (2003) Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 227:266-279
Hsiao, C.D., Tsai, W.Y., and Tsai, H.J. (2002) Isolation and expression of two zebrafish homologues of parvalbumin genes related to chicken CPV3 and mammalian oncomodulin. Mechanisms of Development. (Suppl.) 119:S161-S166
Hsiao, C.D., Hsieh, F.J., and Tsai, H.J. (2001) Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 220(4):323-336