GENOMIC FEATURES ORIGINATING FROM THIS LAB
all 16 genomic features
The distribution of blood cells, hormones and essential nutrients throughout our bodies is dependent on the function of a healthy vasculature. Lymphatic vessels compose a vascular network that functions to drain the waste and fluid which accumulates in our tissues, returning it to the blood circulation. Lymphatic vessels play roles in diseases that include cancer, inflamatory disorders and lymphoedema. Despite the importance of lymphatic vessels, much remains to be understood about the cellular and molecular mechanisms regulating their development.
We study the genetic control of vascular development with a particular emphasis on the lymphatic vasculature. Specifically, we are studying a subset of mutants that fail to form lymphatic vessels while retaining blood circulation. We are also developing transgenic markers of lymphatic endothelial cells and vessels in order to examine the cell biology of lymphangiogenesis in the zebrafish embryo.