ZFIN ID: ZDB-LAB-100302-1
SUMBRE Lab
PI/Director: Sumbre, German
Contact Person: Sumbre, German
Email: sumbre@biologie.ens.fr
URL: http://www.zebrain.biologie.ens.fr
Address: IBENS Ecole Normale Superieure de Paris Section de Neurosciences INSERM U1024 / CNRS UMR8197 46, rue d' Ulm 75230 PARIS CEDEX 05 FRANCE
Country: France
Phone: +33 (1) 44 32 23 68
Fax:
Line Designation: ens


GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS
Neural circuits and behaviour

Neuroethology refers to the study of animal behaviour and its underlying neuronal mechanisms. Aiming to unravel how the nervous system processes cognitive functions and controls animal behaviour, the laboratory uses the zebrafish larva as the experimental model and a multidisciplinary approach, including two-photon calcium imaging to monitor activity of neural networks, motor behaviours, genetic engineering techniques to label, monitor and manipulate activity of specific neurons or entire circuits and mathematical and computational methods for data analysis. It is the combination of disciplines, and the use of a behaving animal model that enables deciphering complex neuroethological questions such as perception of time, decision making, learning & memory and sensory perception.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Privat, M., Sumbre, G. (2020) Naturalistic Behavior: The Zebrafish Larva Strikes Back. Current biology : CB. 30:R27-R29
Privat, M., Romano, S.A., Pietri, T., Jouary, A., Boulanger-Weill, J., Elbaz, N., Duchemin, A., Soares, D., Sumbre, G. (2019) Sensorimotor Transformations in the Zebrafish Auditory System. Current biology : CB. 29(23):4010-4023.e4
Boulanger-Weill, J., Sumbre, G. (2019) Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum. Frontiers in cell and developmental biology. 7:57
Ponce-Alvarez, A., Jouary, A., Privat, M., Deco, G., Sumbre, G. (2018) Whole-Brain Neuronal Activity Displays Crackling Noise Dynamics. Neuron. 100(6):1446-1459.e6
Marachlian, E., Avitan, L., Goodhill, G.J., Sumbre, G. (2018) Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum. Frontiers in neural circuits. 12:46
Boulanger-Weill, J., Candat, V., Jouary, A., Romano, S., Pérez-Schuster, V., Sumbre, G. (2017) Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits. Current biology : CB. 27(12):1707-1720.e5
Pietri, T., Romano, S.A., Pérez-Schuster, V., Boulanger-Weill, J., Candat, V., Sumbre, G. (2017) The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs. Cell Reports. 19:939-948
Pérez-Schuster, V., Kulkarni, A., Nouvian, M., Romano, S.A., Lygdas, K., Jouary, A., Dipoppa, M., Pietri, T., Haudrechy, M., Candat, V., Boulanger-Weill, J., Hakim, V., Sumbre, G. (2016) Correction: Sustained Rhythmic Brain Activity Underlies Visual Motion Perception in Zebrafish. Cell Reports. 17:3089
Pérez-Schuster, V., Kulkarni, A., Nouvian, M., Romano, S.A., Lygdas, K., Jouary, A., Dipoppa, M., Pietri, T., Haudrechy, M., Candat, V., Boulanger-Weill, J., Hakim, V., Sumbre, G. (2016) Sustained Rhythmic Brain Activity Underlies Visual Motion Perception in Zebrafish. Cell Reports. 17:1098-1112
Jouary, A., Haudrechy, M., Candelier, R., Sumbre, G. (2016) A 2D virtual reality system for visual goal-driven navigation in zebrafish larvae. Scientific Reports. 6:34015
Candelier, R., Sriti Murmu, M., Alejo Romano, S., Jouary, A., Debrégeas, G., Sumbre, G. (2015) A microfluidic device to study neuronal and motor responses to acute chemical stimuli in zebrafish. Scientific Reports. 5:12196
Romano, S.A., Pietri, T., Pérez-Schuster, V., Jouary, A., Haudrechy, M., Sumbre, G. (2015) Spontaneous Neuronal Network Dynamics Reveal Circuit's Functional Adaptations for Behavior. Neuron. 85(5):1070-85
Sumbre, G., and Poo, M.M. (2013) Monitoring tectal neuronal activities and motor behavior in zebrafish larvae. Cold Spring Harbor protocols. 2013(9):pdb.prot077131
Pietri, T., Roman, A.C., Guyon, N., Romano, S.A., Washbourne, P., Moens, C.B., de Polavieja, G.G., and Sumbre, G. (2013) The first mecp2-null zebrafish model shows altered motor behaviors. Frontiers in neural circuits. 7:118
Panier, T., Romano, S.A., Olive, R., Pietri, T., Sumbre, G., Candelier, R., and Debrégeas, G. (2013) Fast functional imaging of multiple brain regions in intact zebrafish larvae using Selective Plane Illumination Microscopy. Frontiers in neural circuits. 7:65
Sumbre, G., Muto, A., Baier, H., and Poo, M.M. (2008) Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval. Nature. 456(7218):102-106