ZFIN ID: ZDB-LAB-090410-1
Huh Lab
PI/Director: Huh, Tae-Lin
Contact Person: Koun, Soonil
Email: soonil.koun@gmail.com
Address: Laboratory of Molecular Genetics School of Life Science Kyungpook National University 1370 San-kyuk dong, Buk-gu, Daegu 702-701, Republic of Korea
Country: South Korea
Phone: +82-53-950-5387
Fax: +82-53-943-9755
Line Designation: knu

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Chun, Hang-Suk Graduate Student Kim, Myoung-Jin Graduate Student Kim, Young-Seop Graduate Student
Koo, Tae-Hee Graduate Student Koun, Soonil Graduate Student

Hwang, J., Koun, S., Ha, Y., Jung, J.M. (2023) Zebrafish thrombosis models according to the location of thrombus formation. Annals of translational medicine. 11:309309
Sellaththurai, S., Jung, S., Kim, M.J., Nadarajapillai, K., Ganeshalingam, S., Jeong, J.B., Lee, J. (2023) CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection. Biomolecules. 13(2):
Park, S., Kim, S., Koun, S., Park, H.C., Yoon, W.S., Rim, C.H. (2022) Radioprotective effect of mistletoe extract on intestinal toxicity: in vivo study using adult zebrafish. International Journal of Radiation Biology. 99(5):845-852
Shanaka, K.A.S.N., Jung, S., Madushani, K.P., Wijerathna, H.M.S.M., Neranjan Tharuka, M.D., Kim, M.J., Lee, J. (2022) Generation of viperin-knockout zebrafish by CRISPR/Cas9-mediated genome engineering and the effect of this mutation under VHSV infection. Fish & shellfish immunology. 131:672-681
Kim, D., Koun, S., Kim, S.Y., Ha, Y.R., Choe, J.W., Jung, S.W., Hyun, J.J., Jung, Y.K., Koo, J.S., Yim, H.J., Lee, S.W. (2021) Prokinetic effects of diatrizoate meglumine (Gastrografin®) in a zebrafish for opioid-induced constipation model. Animal cells and systems. 25:264-271
Choe, H., Kim, M.J., Jeon, H.J., Kim, K., Kim, C., Park, J., Shin, J., Lee, S.R., Lee, S.E. (2021) Acute toxicity of the insecticide EPN upon zebrafish (Danio rerio) embryos and its related adverse effects: Verification of abnormal cardiac development and seizure-like events. Ecotoxicology and environmental safety. 222:112544
Shanaka, K.A.S.N., Jung, S., Janson, N.D., Jayasingha, J.R.P., Madushani, K.P., Kim, M.J., Lee, J. (2021) Growth and Antioxidant-Related Effects of the Reestablished Ascorbic Acid Pathway in Zebrafish (Danio rerio) by Genomic Integration of L-Gulonolactone Oxidase From Cloudy Catshark (Scyliorhinus torazame). Frontiers in Physiology. 12:685595
Jung, J., Kim, J., Huh, T.L., Rhee, M. (2021) Trim46 contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos. Animal cells and systems. 25:56-64
Jung, S., Kim, M.J., Sellaththurai, S., Kim, S., Lee, S., Lee, J. (2021) Generation of cd63-deficient zebrafish to analyze the role of cd63 in viral infection. Fish & shellfish immunology. 111:152-159
Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366
Kim, C., Choe, H., Park, J., Kim, G., Kim, K., Jeon, H.J., Moon, J.K., Kim, M.J., Lee, S.E. (2020) Molecular mechanisms of developmental toxicities of azoxystrobin and pyraclostrobin toward zebrafish (Danio rerio) embryos: Visualization of abnormal development using two transgenic lines. Environmental pollution (Barking, Essex : 1987). 270:116087
Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
Choe, S., Huh, T.L., Rhee, M. (2020) Trim45 is essential to the development of the diencephalon and eye in zebrafish embryos. Animal cells and systems. 24:99-106
Kim, M.J., Moon, D., Jung, S., Lee, J., Kim, J. (2020) Cisplatin Nephrotoxicity Is Induced via Poly(ADP-ribose) Polymerase Activation in Adult Zebrafish and Mice. American journal of physiology. Regulatory, integrative and comparative physiology. 318(5):R843-R854
Han, E., Ho Oh, K., Park, S., Chan Rah, Y., Park, H.C., Koun, S., Choi, J. (2020) Analysis of behavioral changes in zebrafish (Danio rerio) larvae caused by aminoglycoside-induced damage to the lateral line and muscles. Neurotoxicology. 78:134-142
Jung, J., Choi, I., Ro, H., Huh, T.L., Choe, J., Rhee, M. (2020) march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos. Molecules and cells. 43(1):76-85
Ngoc, L.T.N., Lee, Y., Chun, H.S., Moon, J.Y., Choi, J.S., Park, D., Lee, Y.C. (2019) Correlation of α/γ-Fe2O3 nanoparticles with the toxicity of particulate matter originating from subway tunnels in Seoul stations, Korea. Journal of hazardous materials. 382:121175
Ismail, T., Lee, H.K., Kim, C., Kim, Y., Lee, H., Kim, J.H., Kwon, S., Huh, T.L., Khang, D., Kim, S.H., Choi, S.C., Lee, H.S. (2019) Comparative analysis of the developmental toxicity in Xenopus laevis and Danio rerio induced by Al2 O3 nanoparticle exposure. Environmental toxicology and chemistry. 38(12):2672-2681
Park, M.H., Kim, A.K., Manandhar, S., Oh, S.Y., Jang, G.H., Kang, L., Lee, D.W., Hyeon, D.Y., Lee, S.H., Lee, H.E., Huh, T.L., Suh, S.H., Hwang, D., Byun, K., Park, H.C., Lee, Y.M. (2019) CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity. eLIFE. 8:
Rhee, J., Han, E., Nam, K.J., Lim, K.H., Chan Rah, Y., Park, S., Koun, S., Park, H.C., Choi, J. (2019) Assessment of hair cell damage and developmental toxicity after fine particulate matter 2.5 μm (PM 2.5) exposure using zebrafish (Danio rerio) models. International journal of pediatric otorhinolaryngology. 126:109611
Rim, C.H., Koun, S., Park, H.C., Lee, S., Kim, C.Y. (2019) Radioprotective effects of Mistletoe extract in Zebrafish embryos in vivo. International Journal of Radiation Biology. 95(8):1150-1159
Kumar, A., Anuppalle, M., Maddirevula, S., Huh, T.L., Choe, J., Rhee, M. (2019) Peli1b governs the brain patterning via ERK signaling pathways in zebrafish embryos. Gene. 694:1-6
Lee, S., Chun, H.S., Lee, J., Park, H.J., Kim, K.T., Kim, C.H., Yoon, S., Kim, W.K. (2018) Plausibility of the zebrafish embryos/larvae as an alternative animal model for autism: A comparison study of transcriptome changes. PLoS One. 13:e0203543
Rah, Y.C., Park, S., Koun, S., Park, H.C., Choi, J. (2018) In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio). Alcohol (Fayetteville, N.Y.). 75:113-121
Rah, Y.C., Han, E.J., Park, S., Rhee, J., Koun, S., Park, H.C., Choi, J. (2018) In vivo assay of the potential gadolinium-induced toxicity for sensory hair cells using a zebrafish animal model. Journal of applied toxicology : JAT. 38(11):1398-1404
Yoo, M.H., Rah, Y.C., Park, S., Goun, S., Im, G.J., Chae, S.W., Jung, H.H., Choi, J. (2018) Impact of Nicotine Exposure on Hair Cell Toxicity and Embryotoxicity During Zebrafish Development. Clinical and experimental otorhinolaryngology. 11(2):109-117
Kumar, A., Huh, T.L., Choe, J., Rhee, M. (2017) Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos. Molecules and cells. 40(12):945-953
Park, S.Y., Lee, C.Y., An, H.R., Kim, H., Lee, Y.C., Park, E.C., Chun, H.S., Yang, H.Y., Choi, S.H., Kim, H.S., Kang, K.S., Park, H.G., Kim, J.P., Choi, Y., Lee, J., Lee, H.U. (2017) Advanced carbon dots via plasma-induced surface functionalization for fluorescent and bio-medical applications. Nanoscale. 9(26):9210-9217
Yoo, K.W., Maddirevula, S., Kumar, A., Ro, H., Huh, T.L., Rhee, M. (2017) Sinup is essential for the integrity of centrosomes and mitotic spindles in zebrafish embryos. Animal cells and systems. 21:93-99
Chun, H.S., Park, D., Eun Lim, S., Jeong, K.H., Park, J.S., Park, H.J., Kang, S., Kang, K.S., Park, H.G., An, H.R., Huh, Y.S., Lee, Y.C. (2017) Two zinc-aminoclays' in-vitro cytotoxicity assessment in HeLa cells and in-vivo embryotoxicity assay in zebrafish. Ecotoxicology and environmental safety. 137:103-112
Anuppalle, M., Maddirevula, S., Kumar, A., Huh, T.L., Choe, J., Rhee, M. (2017) Expression patterns of prune2 is regulated by Notch and retinoic acid signaling pathways in the zebrafish embryogenesis. Gene expression patterns : GEP. 23-24:45-51
Koun, S., Kim, J.D., Rhee, M., Kim, M.J., Huh, T.L. (2016) Spatiotemporal expression pattern of the zebrafish aquaporin 8 family during early developmental stages. Gene expression patterns : GEP. 21(1):1-6
Jeon, H.J., Lee, Y.H., Kim, M.J., Choi, S.D., Park, B.J., Lee, S.E. (2016) Integrated biomarkers induced by chlorpyrifos in two different life stages of zebrafish (Danio rerio) for environmental risk assessment. Environmental Toxicology and Pharmacology. 43:166-174
Oh, S.K., Shin, J.O., Baek, J.I., Lee, J., Bae, J.W., Ankamerddy, H., Kim, M.J., Huh, T.L., Ryoo, Z.Y., Kim, U.K., Bok, J., Lee, K.Y. (2015) Pannexin 3 is required for normal progression of skeletal development in vertebrates. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11):4473-84
Kim, J.D., Kim, E., Koun, S., Ham, H.J., Rhee, M., Kim, M.J., Huh, T.L. (2015) Proper Activity of Histone H3 Lysine 4 (H3K4) Methyltransferase Is Required for Morphogenesis during Zebrafish Cardiogenesis. Molecules and cells. 38(6):580-6
Park, H., Shim, J.S., Kim, B.S., Jung, H.J., Huh, T.L., Kwon, H.J. (2014) Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model. Biochemical and Biophysical Research Communications. 450(1):561-7
Kim, J.D., Kim, H.J., Koun, S., Ham, H.J., Kim, M.J., Rhee, M., Huh, T.L. (2014) Zebrafish Crip2 Plays a Critical Role in Atrioventricular Valve Development by Downregulating the Expression of ECM Genes in the Endocardial Cushion. Molecules and cells. 37(5):406-11
Chun, H.S., Shin, S.H., Ahn, S., Shin, D.S., Choi, S.S., Ahn, J.H., Bae, M.A. (2014) KR-62980 Suppresses Lipid Metabolism Through Inhibition of Cytosolic NADP Isocitrate Dehydrogenase in Zebrafish. Zebrafish. 11:122-8
Anuppalle, M., Maddirevula, S., Huh, T.L., and Rhee, M. (2013) Trb3 Regulates LR Axis formation in zebrafish embryos. Molecules and cells. 36(6):542-547
Chun, H.S., Jeon, J.H., Pagire, H.S., Lee, J.H., Chung, H.C., Park, M.J., So, J.H., Ryu, J.H., Kim, C.H., Ahn, J.H., and Bae, M.A. (2013) Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging. Molecular Biosystems. 9(4):630-633
Park, M.J., Lee, K.R., Shin, D.S., Chun, H.S., Kim, C.H., Ahn, S.H., and Bae, M.A. (2013) Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests. Toxicology letters. 216(1):9-15
Kim, Y.S., Kim, M.J., Koo, T.H., Kim, J.D., Koun, S., Ham, H.J., Lee, Y.M., Rhee, M., Yeo, S.Y., and Huh, T.L. (2012) Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. Biochemical and Biophysical Research Communications. 423(1):140-146
Maddirevula, S., Anuppalle, M., Huh, T.L., Kim, S.H., and Rhee, M. (2012) Rnf11-like is a novel component of NF-kappaB signaling, governing the posterior patterning in the zebrafish embryos. Biochemical and Biophysical Research Communications. 422(4):602-606
Kim, S., Kim, J.D., Chung, A.Y., Kim, H.S., Kim, Y.S., Kim, M.J., Koun, S., Lee, Y.M., Rhee, M., Park, H.C., and Huh, T.L. (2012) Antagonistic Regulation of PAF1C and p-TEFb Is Required for Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(24):8201-8207
Kim, Y., Jung, H.Y., Choe, Y.H., Lee, C., Ko, S.K., Koun, S., Choi, Y., Chung, B.H., Park, B.C., Huh, T.L., Shin, I., and Kim, E. (2012) High-Contrast Reversible Fluorescence Photoswitching of Dye-Crosslinked Dendritic Nanoclusters in Living Vertebrates. Angewandte Chemie (International ed. in English). 51(12):2878-2882
Kim, S., Chung, A.Y., Kim, D., Kim, Y.S., Kim, H.S., Kwon, H.W., Huh, T.L., Park, H.C. (2011) Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos. Molecules and cells. 32(4):383-8
Maddirevula, S., Anuppalle, M., Huh, T.L., Kim, S.H., and Rhee, M. (2011) Nrdp1 governs differentiation of the melanocyte lineage via Erbb3b signaling in the zebrafish embryogenesis. Biochemical and Biophysical Research Communications. 409(3):454-8
Kang, N., Ro, H., Park, Y., Kim, H.T., Huh, T.L., and Rhee, M. (2010) Seson, a novel zinc finger protein, controls cilia integrity for the LR patterning during zebrafish embryogenesis. Biochemical and Biophysical Research Communications. 401(2):169-174
Chung, A.Y., Kim, M.J., Kim, D., Bang, S., Hwang, S.W., Lim, C.S., Lee, S., Park, H.C., and Huh, T.L. (2010) Neuron-specific expression of atp6v0c2 in zebrafish CNS. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(9):2501-2508
Park, J.S., Kim, H.S., Kim, J.D., Seo, J., Chung, K.S., Lee, H.S., Huh, T.L., Jo, I., and Kim, Y.O. (2009) Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(6):1574-1581
Jang, G.H., Park, I.S., Lee, S.H., Huh, T.L., and Lee, Y.M. (2009) Malachite green induces cardiovascular defects in developing zebrafish (Danio rerio) embryos by blocking VEGFR-2 signaling. Biochemical and Biophysical Research Communications. 382(3):486-491
Kim, J.D., Chun, H.S., Kim, S.H., Kim, H.S., Kim, Y.S., Kim, M.J., Shin, J., Rhee, M., Yeo, S.Y., and Huh, T.L. (2009) Normal forebrain development may require continual Wnt antagonism until mid-somitogenesis in zebrafish. Biochemical and Biophysical Research Communications. 381(4):717-721
So, J.H., Chun, H.S., Bae, Y.K., Kim, H.S., Park, Y.M., Huh, T.L., Chitnis, A.B., Kim, C.H., and Yeo, S.Y. (2009) Her4 is necessary for establishing peripheral projections of the trigeminal ganglia in zebrafish. Biochemical and Biophysical Research Communications. 379(1):22-26
Kim, S., Kim, S.H., Kim, H., Chung, A.Y., Cha, Y.I., Kim, C.H., Huh, T.L., and Park, H.C. (2008) Frizzled 8a function is required for oligodendrocyte development in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(11):3324-3331
Jang, G.H., Ha, J.H., Huh, T.L., and Lee, Y.M. (2008) Effect of proton beam on blood vessel formation in early developing zebrafish (Danio rerio) embryos. Archives of Pharmacal Research. 31(6):779-785
Kim, H.S., Shin, J., Kim, S.H., Chun, H.S., Kim, J.D., Kim, Y.S., Kim, M.J., Rhee, M., Yeo, S.Y., and Huh, T.L. (2007) Eye field requires the function of Sfrp1 as a Wnt antagonist. Neuroscience letters. 414(1):26-29
Yeo, S.Y., Kim, M., Kim, H.S., Huh, T.L., and Chitnis, A.B. (2007) Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos. Developmental Biology. 301(2):555-567
Won, M., Ro, H., Park, H.C., Kim, K.E., Huh, T.L., Kim, C.H., and Rhee, M. (2006) Dynamic expression patterns of zebrafish 1G5 (1G5z), a calmodulin kinase-like gene in the developing nervous system. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(3):835-842
Ro, H., Won, M., Lee, S.U., Kim, K.E., Huh, T.L., Kim, C.H., and Rhee, M. (2005) Sinup, a novel Siaz-interacting nuclear protein, modulates neural plate formation in the zebrafish embryos. Biochemical and Biophysical Research Communications. 332(4):993-1003
Yeo, S.Y., Miyashita, T., Fricke, C., Little, M.H., Yamada, T., Kuwada, J.Y., Huh, T.L., Chien, C.B., and Okamoto, H. (2004) Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish. Mechanisms of Development. 121(4):315-324
Ro, H., Kim, K.E., Huh, T.-L., Lee, S.K., and Rhee, M. (2003) Expression pattern of Siaz gene during the zebrafish embryonic development. Gene expression patterns : GEP. 3(4):483-488
Jang, W.S., Kim, E.J., Ro, H., Kim, K.E., Huh, T.L., Kim, C.-H., and Rhee, M. (2003) Expression of a novel type I keratin, DAPK-1 in the dorsal aorta and pronephric duct of the zebrafish embryos. Gene. 312:145-150
Yoo, K.W., Kim, C.H., Park, H.C., Kim, S.H., Kim, H.S., Hong, S.K., Han, S., Rhee, M., and Huh, T.L. (2003) Characterization and expression of a presomitic mesoderm-specific mespo gene in zebrafish. Development genes and evolution. 213(4):203-206
Suh, Y.H., Shin, Y.K., Kook, M.C., Oh, K.I., Park, W.S., Kim, S.H., Lee, I.S., Park, H.J., Huh, T.L., and Park, S.H. (2003) Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. Gene. 307:63-76
Kim, S.-H., Shin, J., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Han, S., Rhee, M., Kim, C.-H., Chitnis, A.B., and Huh, T.-L. (2002) Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. Development (Cambridge, England). 129(19):4443-4455
Hong, S.K., Kim, C.-H., Yoo, K.-W., Kim, H.S., Kudoh, T., Dawid, I.B., and Huh, T.L. (2002) Isolation and expression of a novel neuron-specific onecut homeobox gene in zebrafish. Mechanisms of Development. 112(1-2):199-202
Yeo, S.Y., Little, M.H., Yamada, T., Miyashita, T., Halloran, M.C., Kuwada, J.Y., Huh, T.L., and Okamoto, H. (2001) Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish. Developmental Biology. 230(1):1-17
Park, H.-C., Kim, C.-H., Bae, Y.-K., Yee, S.-Y., Kim, S.-H., Hong, S.-K., Shin, J., Yoo, K.-W., Hibi, M., Hirano, T., Miki, N., Chitnis, A.B., and Huh, T.-L. (2000) Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons. Developmental Biology. 227(2):279-293
Park, H.-C., Hong, S.-K., Kim, H.-S., Kim, S.-H., Yoon, E.-J., Kim, C.-H., Miki, N., and Huh, T.-L. (2000) Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. Neuroscience letters. 279(2):81-84
Xu, X.M., Zhou, X., Carlson, B.A., Kim, L.K., Huh, T.L., Lee, B.J., and Hatfield, D.L. (1999) The zebrafish genome contains two distinct selenocysteine tRNA[Ser]sec genes. FEBS letters. 454(1-2):16-20
Kim, S.-H., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Choi, J.W., Kim, C.-H., Weinstein, B.M., and Huh, T.-L. (1998) Characterization of two frizzled8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos. Mechanisms of Development. 78:193-201
Kim, C.-H., Y.-K. Bae, Y. Yamanaka, S. Yamashita, T. Shimizu, R. Fujii, H.-C. Park, S.-Y. Yeo, T.-L. Huh, M. Hibi, and T. Hirano (1997) Overexpression of neurogenin induces ectopic expression of HuC in zebrafish. Neuroscience letters. 239:113-116
Kim, C.H., Ueshima, E., Muraoka, O., Tanaka, H., Yeo, S.Y., Huh, T.L., and Miki, N. (1996) Zebrafish elav/huC homologue as a very early neuronal marker. Neuroscience letters. 216(2):109-112