ZFIN ID: ZDB-LAB-090325-1
Burns Lab
PI/Director: Burns, Geoff
Burns (Erter), Caroline
Contact Person: Burns (Erter), Caroline
Email: cburns6@partners.org
URL:
Address: Caroline E Burns, PhD Assistant Professor of Medicine MGH Principal Investigator Harvard Stem Cell Institute Massachusetts General Hospital CNY 149 13th Street CVRC, 4th floor, 4138E Charlestown, MA 02129
Country: United States
Phone: 617-643-4552
Fax: 617-726-5806
Line Designation: fb


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 24 genomic features


STATEMENT OF RESEARCH INTERESTS
Our laboratory is interested in understanding the genetic determinants of heart development, pharyngeal arch artery development, and heart regeneration using the zebrafish.


LAB MEMBERS
Gonzalez-Rosa, Juan Manuel Post-Doc Guner, Burcu Post-Doc Paffett-Lugassy, Noelle Post-Doc
Zhao, Long Post-Doc


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Akerberg, A.A., Burns, C.E., Burns, C.G., Nguyen, C. (2019) Deep learning enables automated volumetric assessments of cardiac function in zebrafish. Disease models & mechanisms. 12(10):
Ben-Yair, R., Butty, V.L., Busby, M., Qiu, Y., Levine, S.S., Goren, A., Boyer, L.A., Burns, C.G., Burns, C.E. (2019) H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development (Cambridge, England). 146(19):
Akerberg, A.A., Burns, C.E., Burns, C.G. (2019) Exploring the Activities of RBPMS Proteins in Myocardial Biology. Pediatric Cardiology. 40(7):1410-1418
Gálvez-Santisteban, M., Chen, D., Zhang, R., Serrano, R., Nguyen, C., Zhao, L., Nerb, L., Masutani, E.M., Vermot, J., Burns, C.G., Burns, C.E., Del Álamo, J.C., Chi, N.C. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLIFE. 8:
Zhao, L., Ben-Yair, R., Burns, C.E., Burns, C.G. (2019) Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism. Cell Reports. 26:546-554.e5
Guner-Ataman, B., González-Rosa, J.M., Shah, H.N., Butty, V.L., Jeffrey, S., Abrial, M., Boyer, L.A., Burns, C.G., Burns, C.E. (2018) Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome. Cell Reports. 24:1342-1354.e5
Sánchez-Iranzo, H., Galardi-Castilla, M., Sanz-Morejón, A., González-Rosa, J.M., Costa, R., Ernst, A., Sainz de Aja, J., Langa, X., Mercader, N. (2018) Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart. Proceedings of the National Academy of Sciences of the United States of America. 115(16):4188-4193
González-Rosa, J.M., Sharpe, M., Field, D., Soonpaa, M.H., Field, L.J., Burns, C.E., Burns, C.G. (2018) Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. Developmental Cell. 44:433-446.e7
Sánchez-Iranzo, H., Galardi-Castilla, M., Minguillón, C., Sanz-Morejón, A., González-Rosa, J.M., Felker, A., Ernst, A., Guzmán-Martínez, G., Mosimann, C., Mercader, N. (2018) Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nature communications. 9:428
Natarajan, N., Abbas, Y., Bryant, D.M., Gonzalez-Rosa, J.M., Sharpe, M., Uygur, A., Cocco-Delgado, L.H., Ho, N.N., Gerard, N.P., Gerard, C.J., Macrae, C.A., Burns, C.E., Burns, C.G., Whited, J.L., Lee, R.T. (2018) Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 137(20):2152-2165
Paffett-Lugassy, N., Novikov, N., Jeffrey, S., Abrial, M., Guner-Ataman, B., Sakthivel, S., Burns, C.E., Burns, C.G. (2017) Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field. Development (Cambridge, England). 144(24):4616-4624
González-Rosa, J.M., Burns, C.E., Burns, C.G. (2017) Zebrafish heart regeneration: 15 years of discoveries. Regeneration (Oxford, England). 4:105-123
Abrial, M., Paffett-Lugassy, N., Jeffrey, S., Jordan, D., O'Loughlin, E., Frederick, C.J., Burns, C.G., Burns, C.E. (2017) TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation. Cell Reports. 20:973-983
Manalo, T., May, A., Quinn, J., Lafontant, D.S., Shifatu, O., He, W., Gonzalez-Rosa, J.M., Burns, G.C., Burns, C.E., Burns, A.R., Lafontant, P.J. (2016) Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio (Devario aequipinnatus) and Zebrafish (Danio rerio) Hearts. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 64(11):687-714
Han, P., Bloomekatz, J., Ren, J., Zhang, R., Grinstein, J.D., Zhao, L., Burns, C.G., Burns, C.E., Anderson, R.M., Chi, N.C. (2016) Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 534:700-4
Jahangiri, L., Sharpe, M., Novikov, N., González-Rosa, J.M., Borikova, A., Nevis, K., Paffett-Lugassy, N., Zhao, L., Adams, M., Guner-Ataman, B., Burns, C.E., Burns, C.G. (2016) The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Development (Cambridge, England). 143:113-22
Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K., Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A., Zon, L.I. (2015) Chamber identity programs drive early functional partitioning of the heart. Nature communications. 6:8146
Mahmoud, A.I., O'Meara, C.C., Gemberling, M., Zhao, L., Bryant, D.M., Zheng, R., Gannon, J.B., Cai, L., Choi, W.Y., Egnaczyk, G.F., Burns, C.E., Burns, C.G., MacRae, C.A., Poss, K.D., Lee, R.T. (2015) Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. Developmental Cell. 34(4):387-99
Harrison, M.R., Bussmann, J., Huang, Y., Zhao, L., Osorio, A., Burns, C.G., Burns, C.E., Sucov, H.M., Siekmann, A.F., Lien, C.L. (2015) Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell. 33:442-54
Jang, I.H., Lu, Y.F., Zhao, L., Wenzel, P.L., Kume, T., Datta, S.M., Arora, N., Guiu, J., Lagha, M., Kim, P.G., Do, E.K., Kim, J.H., Schlaeger, T.M., Zon, L.I., Bigas, A., Burns, C.E., Daley, G.Q. (2015) Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 125(9):1418-26
Zhao, L., Borikova, A.L., Ben-Yair, R., Guner-Ataman, B., MacRae, C.A., Lee, R.T., Burns, C.G., and Burns, C.E. (2014) Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proceedings of the National Academy of Sciences of the United States of America. 111(4):1403-1408
Paffett-Lugassy, N., Singh, R., Nevis, K.R., Guner-Ataman, B., O'Loughlin, E., Jahangiri, L., Harvey, R.P., Burns, C.G., and Burns, C.E. (2013) Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis. Nature cell biology. 15(11):1362-1369
Guner-Ataman, B., Paffett-Lugassy, N., Adams, M.S., Nevis, K.R., Jahangiri, L., Obregon, P., Kikuchi, K., Poss, K.D., Burns, C.E., and Burns, C.G. (2013) Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. Development (Cambridge, England). 140(6):1353-1363
Zheng, X., Yang, S., Han, Y., Zhao, X., Zhao, L., Tian, T., Tong, J., Xu, P., Xiong, C., and Meng, A. (2012) Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos. The Journal of biological chemistry. 287(45):38254-38264
Taylor, A.M., Humphries, J.M., White, R.M., Murphey, R.D., Burns, C.E., and Zon, L.I. (2012) Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Experimental hematology. 40(3):228-237
Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8
de Jong, J.L., Burns, C.E., Chen, A.T., Pugach, E., Mayhall, E.A., Smith, A.C., Feldman, H.A., Zhou, Y., and Zon, L.I. (2011) Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 117(16):4234-42
Zhao, X., Zhao, L., Tian, T., Zhang, Y., Tong, J., Zheng, X., and Meng, A. (2010) Interruption of cenph causes mitotic failure and embryonic death and its haploinsufficiency suppresses cancer in zebrafish. The Journal of biological chemistry. 285(36):27924-27934
Deacon, D.C., Nevis, K.R., Cashman, T.J., Zhou, Y., Zhao, L., Washko, D., Guner-Ataman, B., Burns, C.G., and Burns, C.E. (2010) The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development (Cambridge, England). 137(11):1887-1896
Peal, D.S., Burns, C.G., MacRae, C.A., and Milan, D. (2009) Chondroitin sulfate expression is required for cardiac atrioventricular canal formation. Developmental dynamics : an official publication of the American Association of Anatomists. 238(12):3103-3110
Tian, T., Zhao, L., Zhao, X., Zhang, M., and Meng, A. (2009) A zebrafish gene trap line expresses GFP recapturing expression pattern of foxj1b. Journal of genetics and genomics = Yi chuan xue bao. 36(10):581-589
Burns, C.E., Galloway, J.L., Smith, A.C., Keefe, M.D., Cashman, T.J., Paik, E.J., Mayhall, E.A., Amsterdam, A.H., and Zon, L.I. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 113(23):5776-5782
Tian, T., Zhao, L., Zhang, M., Zhao, X., and Meng, A. (2009) Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochemical and Biophysical Research Communications. 380(3):537-542
Devine, C.A., Sbrogna, J.L., Guner, B., Osgood, M., Shen, M.C., and Karlstrom, R.O. (2009) A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary. Developmental Biology. 326(1):143-154
Zhao, L., Zhao, X., Tian, T., Lu, Q., Skrbo-Larssen, N., Wu, D., Kuang, Z., Zheng, X., Han, Y., Yang, S., Zhang, C., and Meng, A. (2008) Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular research. 80(2):200-208
Guner, B., Ozacar, A.T., Thomas, J.E., and Karlstrom, R.O. (2008) Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis. Endocrinology. 149(9):4435-4451
White, R.M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C., Bourque, C., Dovey, M., Goessling, W., Burns, C.E., and Zon, L.I. (2008) Mechanism unknown: prostaglandin E2 may improve HSC therapies. Cell Stem Cell. 2(2):183-189
White, R.M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C. Bourque, C., Dovey, M., Goessling, W., Burns, C.E., and Zon, L.I. (2008) Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis. Cell Stem Cell. 2(2):183-189
Imamura, S., Uchiyama, J., Koshimizu, E., Hanai, J., Raftopoulou, C., Murphey, R.D., Bayliss, P.E., Imai, Y., Burns, C.E., Masutomi, K., Gagos, S., Zon, L.I., Roberts, T.M., and Kishi, S. (2008) A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 3(10):e3364
Paffett-Lugassy, N., Hsia, N., Fraenkel, P.G., Paw, B., Leschinsky, I., Barut, B., Bahary, N., Caro, J., Handin, R., and Zon, L.I. (2007) Functional conservation of erythropoietin signaling in zebrafish. Blood. 110(7):2718-2726
Guner, B., and Karlstrom, R.O. (2007) Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube. Gene expression patterns : GEP. 7(5):596-605
Peng, C.Y., Yajima, H., Burns, C.E., Zon, L.I., Sisodia, S.S., Pfaff, S.L., and Sharma, K. (2007) Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron. 53(6):813-827
Lepilina, A., Coon, A.N., Kikuchi, K., Holdway, J.E., Roberts, R.W., Burns, C.G., and Poss, K.D. (2006) A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration. Cell. 127(3):607-619
Rottbauer, W., Wessels, G., Dahme, T., Just, S., Trano, N., Hassel, D., Burns, C.G., Katus, H.A., and Fishman, M.C. (2006) Cardiac Myosin Light Chain-2. A Novel Essential Component of Thick-Myofilament Assembly and Contractility of the Heart. Circulation research. 99(3):323-331
Carney, S.A., Chen, J., Burns, C.G., Xiong, K.M., Peterson, R.E., and Heideman, W. (2006) Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Molecular pharmacology. 70(2):549-561
Burns, C.G., and MacRae, C.A. (2006) Purification of hearts from zebrafish embryos. Biotechniques. 40(3):274, 276, 278
Burns, C.E., Traver, D., Mayhall, E., Shepard, J.L., and Zon, L.I. (2005) Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes & Development. 19(19):2331-2342
Burns, C.G., Milan, D.J., Grande, E.J., Rottbauer, W., MacRae, C.A., and Fishman, M.C. (2005) High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nature Chemical Biology. 1(5):263-264
Shin, J.T., Priest, J.R., Ovcharenko, I., Ronco, A., Moore, R.K., Burns, C.G., and MacRae, C.A. (2005) Human-zebrafish non-coding conserved elements act in vivo to regulate transcription. Nucleic acids research. 33(17):5437-45
Weber, G.J., Choe, S.E., Dooley, K.A., Paffett-Lugassy, N.N., Zhou, Y., and Zon, L.I. (2005) Mutant-specific gene programs in the zebrafish. Blood. 106(2):521-530
Antkiewicz, D.S., Burns, C.G., Carney, S.A., Peterson, R.E., and Heideman, W. (2005) Heart Malformation is an Early Response to TCDD in Embryonic Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 84(2):368-377
Tyurina, O.V., Guner, B., Popova, E., Feng, J., Schier, A.F., Kohtz, J.D., and Karlstrom, R.O. (2005) Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Developmental Biology. 277(2):537-556
Paffett-Lugassy, N.N., and Zon, L.I. (2005) Analysis of hematopoietic development in the zebrafish. Methods in molecular medicine. 105:171-198
Feng, J., White, B., Tyurina, O.V., Guner, B., Larson, T., Lee, H.Y., Karlstrom, R.O., and Kohtz, J.D. (2004) Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids. Development (Cambridge, England). 131(17):4357-4370
Ransom, D.G., Bahary, N., Niss, K., Traver, D., Burns, C., Trede, N.S., Paffett-Lugassy, N., Saganic, W.J., Lim, C.A., Hersey, C., Zhou, Y., Barut, B.A., Lin, S., Kingsley, P.D., Palis, J., Orkin, S.H., and Zon, L.I. (2004) The Zebrafish moonshine Gene Encodes Transcriptional Intermediary Factor 1gamma, an Essential Regulator of Hematopoiesis. PLoS Biology. 2(8):E237
Mably, J.D., Mohideen, M.A.P.K., Burns, C.G., Chen, J.-N., and Fishman, M.C. (2003) heart of glass regulates the concentric growth of the heart in zebrafish. Current biology : CB. 13(24):2138-2147
Burns, C.E., DeBlasio, T., Zhou, Y., Zhang, J., Zon, L., and Nimer, S.D. (2002) Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Experimental hematology. 30(12):1381-1389
Burns, C. and Zon, L. (2002) Portrait of a stem cell. Developmental Cell. 3:612-613
Davidson, A.J., Dooley, K., Schmidt, B., Paffett-Lugassy, N., White, N., Walderich, B., Odenthal, J., Maischein, H.M., Schulte-Merker, S., Nüsslein-Volhard, C., Thisse, C., Thisse, B., and Zon, L.I. (2001) Functional genomics and mutagenesis screening in the zebrafish identifies genes required for hematopoietic stem cell development. Blood. 98(11):1888
Erter, C.E., Wilm, T.P., Basler, N., Wright, C.V., and Solnica-Krezel, L. (2001) Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development (Cambridge, England). 128(18):3571-3583
Gonzalez, E.M., Fekany-Lee, K., Carmany-Rampey, A., Erter, C., Topczewski, J., Wright, C.V.E., and Solnica-Krezel, L. (2000) Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino. Genes & Development. 14(24):3087-3092
Erter, C.E. (2000) Nodal-related signaling during zebrafish embryogenesis. Ph.D. Thesis.
Erter, C.E., Solnica-Krezel, L., and Wright, C.V.E. (1998) Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Developmental Biology. 204:361-372