ZFIN ID: ZDB-LAB-080228-1
Santoro Lab
PI/Director: Santoro, Massimo
Contact Person: Santoro, Massimo
Email: massimo.santoro@unipd.it
URL: http://massimomsantoro.wixsite.com/santorolab
Address: Cellular and Molecular Biology Dept. of Biology Viale G. Colombo 3, University of Padua 35131 Padova
Country: Italy
Phone: +39 049 827 6270
Fax:
Line Designation: uto


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 16 genomic features


STATEMENT OF RESEARCH INTERESTS
We are interested in cardiovascular biology in particular angiogenesis and vascular myogenesis.


LAB MEMBERS
Pesce, Gabriella Post-Doc Zecchin, Elisabetta Post-Doc Carfora, Immacolata Technical Staff
Gays, Dafne Mugoni, Vera Scarfo, Irene


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M., Weinstein, B.M. (2019) Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in cell and developmental biology. 7:89
Dickmeis, T., Feng, Y., Mione, M.C., Ninov, N., Santoro, M., Spaink, H.P., Gut, P. (2019) Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in cell and developmental biology. 7:15
Norris, D.M., Santoro, M.M. (2018) Before the Pump. Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2763-2764
Sinha, S., Santoro, M.M. (2018) New models to study vascular mural cell embryonic origin: implications in vascular diseases. Cardiovascular research. 114(4):481-491
Louw, J.J., Nunes Bastos, R., Chen, X., Verdood, C., Corveleyn, A., Jia, Y., Breckpot, J., Gewillig, M., Peeters, H., Santoro, M.M., Barr, F., Devriendt, K. (2018) Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings. PLoS Genetics. 14:e1007138
Panieri, E., Millia, C., Santoro, M.M. (2017) Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues.. Free radical biology & medicine. 109:189-200
Panieri, E., Santoro, M.M. (2017) Data on metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions. Data in brief. 12:427-432
Gays, D., Hess, C., Camporeale, A., Ala, U., Provero, P., Mosimann, C., Santoro, M.M. (2017) An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development (Cambridge, England). 144(3):464-478
Chen, X., Gays, D., Milia, C., Santoro, M.M. (2017) Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Reports. 18:1033-1047
Mana, G., Clapero, F., Panieri, E., Panero, V., Böttcher, R.T., Tseng, H.Y., Saltarin, F., Astanina, E., Wolanska, K.I., Morgan, M.R., Humphries, M.J., Santoro, M.M., Serini, G., Valdembri, D. (2016) PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nature communications. 7:13546
Chen, X., Gays, D., Santoro, M.M. (2016) Transgenic Zebrafish. Methods in molecular biology (Clifton, N.J.). 1464:107-114
Martano, C., Mugoni, V., Dal Bello, F., Santoro, M.M., Medana, C. (2015) Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos. Journal of chromatography. A. 1412:59-66
Garaffo, G., Conte, D., Provero, P., Tomaiuolo, D., Luo, Z., Pinciroli, P., Peano, C., D'Atri, I., Gitton, Y., Etzion, T., Gothilf, Y., Gays, D., Santoro, M.M., Merlo, G.R. (2015) The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system. Molecular and cellular neurosciences. 68:103-19
Fortuna, V., Pardanaud, L., Brunet, I., Ola, R., Ristori, E., Santoro, M.M., Nicoli, S., Eichmann, A. (2015) Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons. Cell Reports. 11(11):1786-96
Mercurio, S., Petrillo, S., Chiabrando, D., Bassi, Z.I., Gays, D., Camporeale, A., Vacaru, A., Miniscalco, B., Valperga, G., Silengo, L., Altruda, F., Baron, M.H., Santoro, M.M., Tolosano, E. (2015) The Heme Exporter Flvcr1 Regulates Expansion And Differentiation Of Committed Erythroid Progenitors By Controlling Intracellular Heme Accumulation. Haematologica. 100(6):720-9
Santoro, M.M. (2014) Zebrafish as a model to explore cell metabolism. Trends in endocrinology and metabolism: TEM. 25(10):546-554
Goodman, K.M., Kjær, S., Beuron, F., Knowles, P.P., Nawrotek, A., Burns, E.M., Purkiss, A.G., George, R., Santoro, M., Morris, E.P., McDonald, N.Q. (2014) RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. Cell Reports. 8:1894-904
Santoro, M.M. (2014) Antiangiogenic Cancer Drug Using the Zebrafish Model. Arterioscler. Thromb. Vasc. Biol.. 34(9):1846-53
Mugoni, V., Camporeale, A., Santoro, M.M. (2014) Analysis of Oxidative Stress in Zebrafish Embryos. Journal of visualized experiments : JoVE. (89)
Whitesell, T.R., Kennedy, R.M., Carter, A.D., Rollins, E.L., Georgijevic, S., Santoro, M.M., Childs, S.J. (2014) An alpha-smooth muscle actin (acta2/alphasma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells. PLoS One. 9:e90590
Garaffo, G., Provero, P., Molineris, I., Pinciroli, P., Peano, C., Battaglia, C., Tomaiuolo, D., Etzion, T., Gothilf, Y., Santoro, M., and Merlo, G.R. (2013) Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Frontiers in Experimental Endocrinology. 4:203
Mugoni, V., Medana, C., and Santoro, M.M. (2013) (13)C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos. Nature Protocols. 8(12):2337-2347
Gays, D., and Santoro, M.M. (2013) The admiR-able advances in cardiovascular biology through the zebrafish model system. Cellular and molecular life sciences : CMLS. 70(14):2489-503
Follo, C., Ozzano, M., Montalenti, C., Santoro, M.M., and Isidoro, C. (2013) Knock-down of Cathepsin D in zebrafish fertilized eggs determines congenital myopathy. Bioscience Reports. 33(2):e00034
Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M.P., Medana, C., Stainier, D.Y., Bakkers, J., and Santoro, M.M. (2013) Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell. 152(3):504-518
Santoro, M.M. (2011) "Fishing" for endothelial microRNA functions and dysfunction. Vascular Pharmacology. 55(4):60-8
Follo, C., Ozzano, M., Mugoni, V., Castino, R., Santoro, M., and Isidoro, C. (2011) Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish. PLoS One. 6(7):e21908
Grimes, A.C., Durán, A.C., Sans-Coma, V., Hami, D., Santoro, M.M., and Torres, M. (2010) Phylogeny informs ontogeny: a proposed common theme in the arterial pole of the vertebrate heart. Evolution & development. 12(6):552-567
Santoro, M.M., Pesce, G., and Stainier, D.Y. (2009) Characterization of vascular mural cells during zebrafish development. Mechanisms of Development. 126(8-9):638-649
Gyrd-Hansen, M., Darding, M., Miasari, M., Santoro, M.M., Zender, L., Xue, W., Tenev, T., da Fonseca, P.C., Zvelebil, M., Bujnicki, J.M., Lowe, S., Silke, J., and Meier, P. (2008) IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nature cell biology. 10(11):1309-1317
Fish, J.E., Santoro, M.M., Morton, S.U., Yu, S., Yeh, R.F., Wythe, J.D., Ivey, K.N., Bruneau, B.G., Stainier, D.Y., and Srivastava, D. (2008) miR-126 regulates angiogenic signaling and vascular integrity. Developmental Cell. 15(2):272-284
Santoro, M.M., Samuel, T., Mitchell, T., Reed, J.C., and Stainier, D.Y. (2007) Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nature Genetics. 39(11):1397-1402
Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology. 307(1):29-42
Pauls, S., Zecchin, E., Tiso, N., Bortolussi, M., and Argenton, F. (2007) Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Developmental Biology. 304(2):875-890
Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdottir, E., Gnugge, L., Bortolussi, M., Driever, W., and Argenton, F. (2007) Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish. Developmental Biology. 301(1):192-204
Mavropoulos, A., Devos, N., Biemar, F., Zecchin, E., Argenton, F., Edlund, H., Motte, P., Martial, J.A., and Peers, B. (2005) sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Developmental Biology. 285(1):211-223
Zecchin, E., Conigliaro, A., Tiso, N., Argenton, F., and Bortolussi, M. (2005) Expression analysis of jagged genes in zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 233(2):638-645
Filippi, A., Tiso, N., Deflorian, G., Zecchin, E., Bortolussi, M., and Argenton, F. (2005) The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord. Proceedings of the National Academy of Sciences of the United States of America. 102(12):4377-4382
Zecchin, E., Mavropoulos, A., Devos, N., Filippi, A., Tiso, N., Meyer, D., Peers, B., Bortolussi, M., Argenton, F. (2004) Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Developmental Biology. 268(1):174-184
Argenton, F., Zecchin, E., and Bortolussi, M. (1999) Early appearance of pancreatic hormone-expressing cells in the zebrafish embryo. Mechanisms of Development. 87(1-2):217-221