ZFIN ID: ZDB-LAB-071212-1
The Zhao Laboratory
PI/Director: Zhao, Xinping
Contact Person: Zhao, Xinping
Email: Xinping.Zhao@uth.tmc.edu
URL:
Address: Department of Ophthalmology & Visual Science University of Texas Health Science Center at Houston 6431 Fannin St., MSB 7.024 Houston, TX 77030 U.S.A.
Country: United States
Phone: 713-500-5989, 713-500-6027
Fax: 713-500-0684
Line Designation: xz


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 10 genomic features


STATEMENT OF RESEARCH INTERESTS
The overall objective of our laboratory is to study biology, development, and diseases of the anterior segment of the eye, including the cornea, lens, iris, cillary body, and anterior angle. There are a number of human disorders involving this complex structure of the eye such as corneal dystrophy, glaucoma, and anterior segment dysgeneses. The ultimate goal is to develop novel and more precise diagnostics, identify better pharmaceutical drugs, and design more effective treatments and preventions to the human anterior eye diseases. We use genetic and transgenic approaches to develop zebrafish models of several anterior eye disorders. We are also interested in studying angiogenesis using the corneal model and generating genetic resources such as chromosomal rearrangement mutants in zebrafish.


LAB MEMBERS
Yoshikawa, Shunichi Post-Doc Ma, Xiaoping Research Staff Nakamura, Hisashi Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Yoshikawa, S., Vila, A., Segelken, J., Lin, Y.P., Mitchell, C.K., Nguyen, D., O'Brien, J. (2017) Zebrafish Connexin 79.8 (Gja8a): A lens connexin used as an electrical synapse in some neurons. Developmental Neurobiology. 77(5):548-561
Beyer, J., Zhao, X.C., Yee, R., Khaliq, S., McMahon, T.T., Ying, H., Yue, B.Y., and Malicki, J.J. (2010) The role of crumbs genes in the vertebrate cornea. Investigative ophthalmology & visual science. 51(9):4549-4556
Yoshikawa, S., Kawakami, K., and Zhao, X.C. (2008) G2R Cre reporter transgenic zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(9):2460-2465
Yoshikawa, S., Norcom, E., Nakamura, H., Yee, R.W., and Zhao, X.C. (2007) Transgenic analysis of the anterior eye-specific enhancers of the zebrafish gelsolin-like 1 (gsnl1) gene. Developmental dynamics : an official publication of the American Association of Anatomists. 236(7):1929-1938
Zhao, X.C., Yee, R.W., Norcom, E., Burgess, H., Avanesov, A.S., Barrish, J.P., and Malicki, J. (2006) The zebrafish cornea: structure and development. Investigative ophthalmology & visual science. 47(10):4341-4348