ZFIN ID: ZDB-LAB-070815-1
Cuppen Lab
PI/Director: Cuppen, Edwin
Contact Person: Cuppen, Edwin
Email: ecuppen@niob.knaw.nl
URL: http://www.hubrecht.eu/research/cuppen/index.html
Address: Genome Biology Group Hubrecht Institute Uppsalalaan 8 3584 CT Utrecht The Netherlands
Country: Netherlands
Phone: +31 30 2121969
Fax: +31 30 2516554
Line Designation: hu


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 47 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Guryev, Victor Post-Doc Nijman, Ies Post-Doc Feitsma, Harma Graduate Student
de Bruijn, Ewart Research Staff van Roekel, Henk Research Staff Verheul, Mark Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
de Bruin, A., Cornelissen, P.W., Kirchmaier, B.C., Mokry, M., Iich, E., Nirmala, E., Liang, K.H., Végh, A.M., Scholman, K.T., Groot Koerkamp, M.J., Holstege, F.C., Cuppen, E., Schulte-Merker, S., Bakker, W.J. (2016) Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic acids research. 44(8):3549-66
Kuijk, E., Geijsen, N., Cuppen, E. (2015) Pluripotency in the light of the developmental hourglass. Biological reviews of the Cambridge Philosophical Society. 90(2):428-43
van Heesch, S., Simonis, M., van Roosmalen, M.J., Pillalamarri, V., Brand, H., Kuijk, E.W., de Luca, K.L., Lansu, N., Braat, A.K., Menelaou, A., Hao, W., Korving, J., Snijder, S., van der Veken, L.T., Hochstenbach, R., Knegt, A.C., Duran, K., Renkens, I., Alekozai, N., Jager, M., Vergult, S., Menten, B., de Bruijn, E., Boymans, S., Ippel, E., van Binsbergen, E., Talkowski, M.E., Lichtenbelt, K., Cuppen, E., Kloosterman, W.P. (2014) Genomic and functional overlap between somatic and germline chromosomal rearrangements. Cell Reports. 9:2001-10
Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J., van Oudenaarden, A. (2014) Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 159:662-75
Kettleborough, R.N., Busch-Nentwich, E.M., Harvey, S.A., Dooley, C.M., de Bruijn, E., van Eeden, F., Sealy, I., White, R.J., Herd, C., Nijman, I.J., Fényes, F., Mehroke, S., Scahill, C., Gibbons, R., Wali, N., Carruthers, S., Hall, A., Yen, J., Cuppen, E., and Stemple, D.L. (2013) A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature. 496(7446):494-7
Joziasse, I.C., Smith, K.A., Chocron, S., van Dinther, M., Guryev, V., van de Smagt, J.J., Cuppen, E., Ten Dijke, P., Mulder, B.J., Maslen, C.L., Reshey, B., Doevendans, P.A., and Bakkers, J. (2011) ALK2 mutation in a patient with Down's syndrome and a congenital heart defect. European journal of human genetics : EJHG. 19(4):389-93
Clark, M.D., Guryev, V., Bruijn, E., Nijman, I.J., Tada, M., Wilson, C., Deloukas, P., Postlethwait, J.H., Cuppen, E., and Stemple, D.L. (2011) Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish. Methods in cell biology. 104:219-235
Kettleborough, R.N., Bruijn, E., Eeden, F., Cuppen, E., and Stemple, D.L. (2011) High-throughput target-selected gene inactivation in zebrafish. Methods in cell biology. 104:121-127
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource and Hubrecht laboratory. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., Winkler, S., Brand, M., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource, MPI Dresden, and Hubrecht laboratory. ZFIN Direct Data Submission.
Smith, K.A., Joziasse, I.C., Chocron, S., van Dinther, M., Guryev, V., Verhoeven, M.C., Rehmann, H., van der Smagt, J.J., Doevendans, P.A., Cuppen, E., Mulder, B.J., Ten Dijke, P., and Bakkers, J. (2009) Dominant-Negative ALK2 Allele Associates With Congenital Heart Defects. Circulation. 119(24):3062-3069
Brittijn, S.A., Duivesteijn, S.J., Belmamoune, M., Bertens, L.F., Bitter, W., Debruijn, J.D., Champagne, D.L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C.M., Janssen, R.A., de Jong, I.M., de Kloet, E.R., Kros, A., Meijer, A.H., Metz, J.R., van der Sar, A.M., Schaaf, M.J., Schulte-Merker, S., Spaink, H.P., Tak, P.P., Verbeek, F.J., Vervoordeldonk, M.J., Vonk, F.J., Witte, F., Yuan, H., and Richardson, M.K. (2009) Zebrafish development and regeneration: new tools for biomedical research. The International journal of developmental biology. 53(5-6):835-850
de Bruijn, E., Cuppen, E., and Feitsma, H. (2009) Highly Efficient ENU Mutagenesis in Zebrafish. Methods in molecular biology (Clifton, N.J.). 546:3-12
Feitsma, H., Akay, A., and Cuppen, E. (2008) Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos. Nucleic acids research. 36(12):4047-4056
Feitsma, H., de Bruijn, E., van de Belt, J., Nijman, I.J., and Cuppen, E. (2008) Mismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line. Mutagenesis. 23(4):325-329
Feitsma, H., Kuiper, R.V., Korving, J., Nijman, I.J., and Cuppen, E. (2008) Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors. Cancer research. 68(13):5059-5066
Feitsma, H., and Cuppen, E. (2008) Zebrafish as a cancer model. Molecular cancer research : MCR. 6(5):685-694
Leal, M.C., Feitsma, H., Cuppen, E., França, L.R., and Schulz, R.W.. (2008) Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1. Cell and tissue research. 332(1):133-139
Blaschke, R.J., Hahurij, N.D., Kuijper, S., Just, S., Wisse, L.J., Deissler, K., Maxelon, T., Anastassiadis, K., Spitzer, J., Hardt, S.E., Scholer, H., Feitsma, H., Rottbauer, W., Blum, M., Meijlink, F., Rappold, G., and Gittenberger-de Groot, A.C. (2007) Targeted Mutation Reveals Essential Functions of the Homeodomain Transcription Factor Shox2 in Sinoatrial and Pacemaking Development. Circulation. 115(14):1830-1838
Feitsma, H., Leal, M.C., Moens, P.B., Cuppen, E., and Schulz, R.W. (2007) Mlh1 Deficiency In Zebrafish Results In Male Sterility And Aneuploid As Well As Triploid Progeny In Females. Genetics. 175(4):1561-1569
Kapsimali, M., Kloosterman, W.P., de Bruijn, E., Rosa, F., Plasterk, R.H., and Wilson, S.W. (2007) MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome biology. 8(8):R173
Kloosterman, W.P., Steiner, F.A., Berezikov, E., de Bruijn, E., van de Belt, J., Verheul, M., Cuppen, E., and Plasterk, R.H. (2006) Cloning and expression of new microRNAs from zebrafish. Nucleic acids research. 34(9):2558-2569
Guryev, V., Koudijs, M.J., Berezikov, E., Johnson, S.L., Plasterk, R.H., van Eeden, F.J., and Cuppen, E. (2006) Genetic variation in the zebrafish. Genome research. 16(4):491-497
Kloosterman, W.P., Wienholds, E., de Bruijn, E., Kauppinen, S., and Plasterk, R.H. (2006) In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nature Methods. 3(1):27-29
Wienholds, E., van Eeden, F., Kosters, M., Mudde, J., Plasterk, R.H., and Cuppen, E. (2003) Efficient target-selected mutagenesis in zebrafish. Genome research. 13:2700-2707
Wienholds, E., Koudijs, M.J., van Eeden, F.J., Cuppen, E., and Plasterk, R.H. (2003) The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nature Genetics. 35(3):217-218
Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., and Clevers, H. (2003) The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature. 425(6958):633-637