ZFIN ID: ZDB-LAB-051005-1
Evans Lab
PI/Director: Evans, Todd
Contact Person: Evans, Todd
Email: tre2003@med.cornell.edu
URL: http://toddevanslab.net
Address: Weill Cornell Medical College Cornell University Dept. of Surgery, LC-711 1300 York Ave. New York, NY 10021 USA
Country: United States
Phone: (212) 746-9487
Fax: (212) 746-7378
Line Designation: wcm

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Function and Regulation of GATA Transcription Factors for Embryonic Development, Organ Morphogenesis, and Cell Differentiation.

The lab focuses on a small group of vertebrate transcriptional regulatory proteins called GATA factors. These proteins function to regulate a variety of cell specification, differentiation, and morphogenetic programs during embryogenesis and throughout life. We are particularly interested in the embryonic signaling programs that regulate the genes encoding GATA factors, including the Bone Morphogenetic Proteins (BMPs) and WNTs. There are several major programs in the lab, studying erythropoiesis (red blood cell development) and cardiogenesis (heart development). We also use murine and human ESC models to understand the role of GATA factors in various disease states. Recently we are developing projects in chemical biology and stem cells in aging.


Cook, B., Walker, N., Zhang, Q., Chen, S., Evans, T. (2021) The small molecule DIPQUO promotes osteogenic differentiation via inhibition of glycogen synthase kinase 3 β signaling. The Journal of biological chemistry. 296:100696
Banks, K.M., Lan, Y., Evans, T. (2021) Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA. Cell Reports. 34:108632
Sam, J., Mercer, E.J., Torregroza, I., Banks, K.M., Evans, T. (2020) Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis. Biology Open. 9(6):
Pandey, S., Banks, K.M., Kumar, R., Kuo, A., Wen, D., Hla, T., Evans, T. (2020) Sphingosine Kinases Protect Murine ESCs from Sphingosine-induced Cell Cycle Arrest. Stem cells (Dayton, Ohio). 38(5):613-623
Cook, B., Rafiq, R., Lee, H., Banks, K.M., El-Debs, M., Chiaravalli, J., Glickman, J.F., Das, B.C., Chen, S., Evans, T. (2019) Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β. Cell chemical biology. 26(7):926-935.e6
Lan, Y., Pan, H., Li, C., Banks, K.M., Sam, J., Ding, B., Elemento, O., Goll, M.G., Evans, T. (2019) TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Cell Reports. 26:720-732.e4
Surya, S.L., Long, M.J.C., Urul, D.A., Zhao, Y., Mercer, E.J., Elsaid, I.M., Evans, T., Aye, Y. (2018) Cardiovascular small heat shock protein HSPB7 is a kinetically-privileged RES sensor. ACS Chemical Biology. 13(7):1824-1831
Mercer, E.J., Lin, Y.F., Cohen-Gould, L., Evans, T. (2018) Hspb7 is a Cardioprotective Chaperone Facilitating Sarcomeric Proteostasis. Developmental Biology. 435(1):41-55
Mendelson, K., Pandey, S., Hisano, Y., Carellini, F., Das, B., Hla, T., Evans, T. (2017) The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine Levels during zebrafish embryogenesis. eLIFE. 6
Li, C., Evans, T., Goll, M.G. (2016) Epigenetic regulation of hematopoietic stem cell development. Methods in cell biology. 135:431-48
Sundaravel, S., Duggan, R., Bhagat, T., Ebenezer, D.L., Liu, H., Yu, Y., Bartenstein, M., Unnikrishnan, M., Karmakar, S., Liu, T.C., Torregroza, I., Quenon, T., Anastasi, J., McGraw, K.L., Pellagatti, A., Boultwood, J., Yajnik, V., Artz, A., Le Beau, M.M., Steidl, U., List, A.F., Evans, T., Verma, A., Wickrema, A. (2015) Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes. Proceedings of the National Academy of Sciences of the United States of America. 112:E6359-68
Li, C., Lan, Y., Schwartz-Orbach, L., Korol, E., Tahiliani, M., Evans, T., Goll, M.G. (2015) Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence. Cell Reports. 12(7):1133-43
Mendelson, K., Lan, Y., Hla, T., Evans, T. (2015) Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 244(8):948-54
Lundquist, M.R., Storaska, A.J., Liu, T.C., Larsen, S.D., Evans, T., Neubig, R.R., Jaffrey, S.R. (2014) Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.. Cell. 156(3):563-76
Das, B.C., McCormick, L., Thapa, P., Karki, R., and Evans, T. (2013) Use of zebrafish in chemical biology and drug discovery. Future Medicinal Chemistry. 5(17):2103-2119
Rosenfeld, G.E., Mercer, E.J., Mason, C.E., and Evans, T. (2013) Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis. Developmental Biology. 381(2):389-400
Novikov, N., and Evans, T. (2013) Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling. Development (Cambridge, England). 140(18):3787-98
Gupta, V., Gemberling, M., Karra, R., Rosenfeld, G.E., Evans, T., and Poss, K.D. (2013) An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle. Current biology : CB. 23(13):1221-7
Choudhuri, A., Maitra, U., and Evans, T. (2013) Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110(24):9818-9823
Chang, S.H., Lu, Y.C., Li, X., Hsieh, W.Y., Xiong, Y., Ghosh, M., Evans, T., Elemento, O., and Hla, T. (2013) Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of VEGF-A expression and angiogenesis. The Journal of biological chemistry. 288(7):4908-4921
Mendelson, K., Zygmunt, T., Torres-Vazquez, J., Evans, T., and Hla, T. (2013) Sphingosine-1-Phosphate Receptors S1pr1 and S1pr2 Cooperatively Regulate Embryonic Vascular Development. The Journal of biological chemistry. 288(4):2143-2156
Berman, N., Lectura, M., Thurman, J.M., Reinecke, J., Raff, A.C., Melamed, M.L., Quan, Z., Evans, T., Meyer, T.W., and Hostetter, T.H. (2013) A Zebrafish Model for Uremic Toxicity: Role of the Complement Pathway. Blood Purification. 35(4):265-269
Xu, C., Fan, Z.P., Müller, P., Fogley, R., Dibiase, A., Trompouki, E., Unternaehrer, J., Xiong, F., Torregroza, I., Evans, T., Megason, S.G., Daley, G.Q., Schier, A.F., Young, R.A., and Zon, L.I. (2012) Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway. Developmental Cell. 22(3):625-238
Torregroza, I., Holtzinger, A., Mendelson, K., Liu, T.C., Hla, T., and Evans, T. (2012) Regulation of a Vascular Plexus by gata4 Is Mediated in Zebrafish through the Chemokine sdf1a. PLoS One. 7(10):e46844
Sedletcaia, A., and Evans, T. (2011) Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes. Developmental dynamics : an official publication of the American Association of Anatomists. 240(6):1548-1557
Rikin, A., Rosenfeld, G.E., McCartin, K., and Evans, T. (2010) A reverse genetic approach to test functional redundancy during embryogenesis. Journal of visualized experiments : JoVE. (42)
Choudhuri, A., Evans, T., and Maitra, U. (2010) Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development. Developmental dynamics : an official publication of the American Association of Anatomists. 239(6):1632-1644
Das, B.C., McCartin, K., Liu, T.C., Peterson, R.T., and Evans, T. (2010) A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity. PLoS One. 5(4):e10004
Kikuchi, K., Holdway, J.E., Werdich, A.A., Anderson, R.M., Fang, Y., Egnaczyk, G.F., Evans, T., MacRae, C.A., Stainier, D.Y., and Poss, K.D. (2010) Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 464(7288):601-605
Rikin, A., and Evans, T. (2010) The tbx/bHLH transcription factor mga regulates gata4 and organogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 239(2):535-547
Hooper, A.T., Shmelkov, S.V., Gupta, S., Milde, T., Bambino, K., Gillen, K., Goetz, M., Chavala, S., Baljevic, M., Murphy, A.J., Valenzuela, D.M., Gale, N.W., Thurston, G., Yancopoulos, G.D., Vahdat, L., Evans, T., and Rafii, S. (2009) Angiomodulin Is a Specific Marker of Vasculature and Regulates Vascular Endothelial Growth Factor-A-Dependent Neoangiogenesis. Circulation research. 105(2):201-208
Torregroza, I., Evans, T., and Das, B.C. (2009) A forward chemical screen using zebrafish embryos with novel 2-substituted 2H-chromene derivatives. Chemical Biology & Drug Design. 73(3):339-345
McReynolds, L.J., Tucker, J., Mullins, C.M.C., and Evans, T. (2008) Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish. Experimental hematology. 36(12):1604-1615
Kadereit, B., Kumar, P., Wang, W.J., Miranda, D., Snapp, E.L., Severina, N., Torregroza, I., Evans, T., and Silver, D.L. (2008) Evolutionarily conserved gene family important for fat storage. Proceedings of the National Academy of Sciences of the United States of America. 105(1):94-99
Holtzinger, A., and Evans, T. (2007) Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes. Developmental Biology. 312(2):613-622
McReynolds, L.J., Gupta, S., Figueroa, M.E., Mullins, M.C., and Evans, T. (2007) Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood. 110(12):3881-3890
Stanton, S.E., McReynolds, L.J., Evans, T., and Schreiber-Agus, N. (2006) YAF2 inhibits caspase 8-mediated apoptosis and regulates cell survival during zebrafish embryogenesis. The Journal of biological chemistry. 281(39):28782-28793
Gupta, S., Zhu, H., Zon, L.I., and Evans, T. (2006) BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development (Cambridge, England). 133(11):2177-2187
Holtzinger, A., and Evans, T. (2005) Gata4 regulates the formation of multiple organs. Development (Cambridge, England). 132(17):4005-4014
Oren, T., Torregroza, I., and Evans, T. (2005) An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling. Nucleic acids research. 33(13):4357-4367
Heicklen-Klein, A., McReynolds, L.J., and Evans, T. (2005) Using the zebrafish model to study GATA transcription factors. Seminars in cell & developmental biology. 16(1):95-106
Heicklen-Klein, A., and Evans, T. (2004) T-box binding sites are required for activity of a cardiac GATA-4 enhancer. Developmental Biology. 267(2):490-504