ZFIN Lab: Zhao Lab

ZFIN ID: ZDB-LAB-050404-1

Zhao Lab

PI/Director:	Zhao, Qingshun
Contact Person:	Zhao, Qingshun
URL:
Address:	Model Animal Research Center Nanjing University 308 Xuefu Road, Pukou District Nanjing, 210032 China
Country:	China
Phone:	+86 25 58641527
Fax:	+86 25 58641500
Line Designation:	nju

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 31 genomic features

STATEMENT OF RESEARCH INTERESTS

We are investigating the roles of retinoid signaling and fibronectin-integrin signaling in early development of vertebrates and making biosentinels for monitoring environmental toxicants using zebrafish.

LAB MEMBERS

Hu, Ping Graduate Student	Song, Wei Graduate Student	Sun, Lun Graduate Student
Wang, Xiaolin Graduate Student	Xu, Fang Graduate Student	Zou, Zhiying Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Cao, S., Dong, Z., Dong, X., Jia, W., Zhou, F., Zhao, Q. (2023) Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Zebrafish. 20:101810-18

Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)

Li, N., Jiang, D., He, L., Yue, Y., Zhang, Q., Wang, S., Zhang, Y., Wei, Y., Zhao, Q. (2022) Both prokaryotes and eukaryotes produce an immune response against plasmids with 5'-GTTTGTT-3'. Cell & Bioscience. 12:87

Dong, X., Jiang, D., Wang, L., Zhao, J., Yu, L., Huang, Y., Wu, X., Zhu, Y., Zhao, Y., Zhao, Q., Zhang, G., Li, X. (2022) VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion. iScience. 25:104042

He, L., Zhang, Q., Jiang, D., Zhang, Y., Wei, Y., Yang, Y., Li, N., Wang, S., Yue, Y., Zhao, Q. (2021) Zebrafish foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression. Journal of genetics and genomics = Yi chuan xue bao. 49(6):559-568

Li, N., Gao, S., Wang, S., He, S., Wang, J., He, L., Jiang, D., Shi, Y.S., Zhang, J., Gu, Y., Chen, T., Kong, M., Xu, X., Zhao, Q. (2021) Attractin Participates in Schizophrenia by Affecting Testosterone Levels. Frontiers in cell and developmental biology. 9:755165

Zhang, Y., Zhao, W., Chen, Y., Yuan, H., Fang, H., Yao, S., Zhang, C., Xu, H., Li, N., Liu, Z., Guo, Z., Zhao, Q., Liang, Y., He, W. (2021) Rational construction of a reversible arylazo-based NIR probe for cycling hypoxia imaging in vivo. Nature communications. 12:2772

Zhang, Q., Liang, D., Yue, Y., He, L., Li, N., Jiang, D., Hu, P., Zhao, Q. (2020) Axenfeld-Rieger syndrome-associated mutants of the transcription factor FOXC1 abnormally regulate NKX2-5 in model zebrafish embryos. The Journal of biological chemistry. 295(33):11902-11913

Jia, W., Liang, D., Li, N., Liu, M., Dong, Z., Li, J., Dong, X., Yue, Y., Hu, P., Yao, J., Zhao, Q. (2018) Zebrafish microRNA miR-210-5p inhibits primitive myelopoiesis by silencing foxj1b and slc3a2a mRNAs downstream of gata4/5/6 transcription factor genes. The Journal of biological chemistry. 294(8):2732-2743

Li, J., Zhao, Y., He, L., Huang, Y., Yang, X., Yu, L., Zhao, Q., Dong, X. (2018) Znfl1s are essential for patterning the anterior-posterior axis of zebrafish posterior hindbrain by acting as direct target genes of retinoic acid. Mechanisms of Development. 155:27-33

Li, J., Gao, F., Zhao, Y., He, L., Huang, Y., Yang, X., Zhou, Y., Yu, L., Zhao, Q., Dong, X. (2018) Zebrafish znfl1s regulate left-right asymmetry patterning through controlling the expression of fgfr1a. Journal of Cellular Physiology. 234(3):1987-1995

Zhou, L., Feng, Y., Wang, F., Dong, X., Jiang, L., Liu, C., Zhao, Q., Li, K. (2018) Generation of all-male-like sterile zebrafish by eliminating primordial germ cells at early development. Scientific Reports. 8:1834

Yue, Y., Jiang, M., He, L., Zhang, Z., Zhang, Q., Gu, C., Liu, M., Li, N., Zhao, Q. (2017) The transcription factor Foxc1a in zebrafish directly regulates expression of nkx2.5, encoding a transcriptional regulator of cardiac progenitor cells.. The Journal of biological chemistry. 293(2):638-650

Gong, J., Wang, X., Zhu, C., Dong, X., Zhang, Q., Wang, X., Duan, X., Qian, F., Shi, Y., Gao, Y., Zhao, Q., Chai, R., Liu, D. (2017) Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in molecular neuroscience. 10:274

Dong, X., Li, J., He, L., Gu, C., Jia, W., Yue, Y., Li, J., Zhang, Q., Chu, L., Zhao, Q. (2017) Zebrafish Znfl1 proteins control the expression of hoxb1b gene in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 genes.. The Journal of biological chemistry. 292(31):13045-13055

Chen, X., Sheng, X., Zhuang, W., Sun, X., Liu, G., Shi, X., Huang, G., Mei, Y., Li, Y., Pan, X., Liu, Y., Li, Z., Zhao, Q., Yan, B., Zhao, C. (2017) GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity. Genetics in medicine : official journal of the American College of Medical Genetics. 19(8):945-954

Zhu, Z., Zhao, Y., Li, J., Tao, L., Shi, P., Wei, Z., Sheng, X., Shen, D., Liu, Z., Zhou, L., Tian, C., Fan, F., Shen, C., Zhu, P., Wang, A., Chen, W., Zhao, Q., Lu, Y. (2016) Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR. Molecular Carcinogenesis. 55(10):1399-410

Zhang, B., Zheng, H., Huang, B., Li, W., Xiang, Y., Peng, X., Ming, J., Wu, X., Zhang, Y., Xu, Q., Liu, W., Kou, X., Zhao, Y., He, W., Li, C., Chen, B., Li, Y., Wang, Q., Ma, J., Yin, Q., Kee, K., Meng, A., Gao, S., Xu, F., Na, J., Xie, W. (2016) Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature. 537:553-557

Xu, S., Cao, S., Zou, B., Yue, Y., Gu, C., Chen, X., Wang, P., Dong, X., Xiang, Z., Li, K., Zhu, M., Zhao, Q., Zhou, G. (2016) An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease. Genome biology. 17:186

Hong, S., Hu, P., Marino, J., Hufnagel, S.B., Hopkin, R.J., Toromanović, A., Richieri-Costa, A., Ribeiro-Bicudo, L.A., Kruszka, P., Roessler, E., Muenke, M. (2016) Dominant-negative Kinase Domain Mutations in FGFR1 Can Explain the Clinical Severity of Hartsfield Syndrome. Human molecular genetics. 25(10):1912-1922

Han, R., Zhao, Q., Zong, S., Miao, S., Song, W., Wang, L. (2016) A novel TRIM family member, trim69, regulates zebrafish development through p53-mediated apoptosis. Molecular reproduction and development. 83(5):442-54

Han, R., Wang, R., Zhao, Q., Han, Y., Zong, S., Miao, S., Song, W., Wang, L. (2016) Trim69 regulates zebrafish brain development by ap-1 pathway. Scientific Reports. 6:24034

Li, J., Yue, Y., Zhao, Q. (2016) Retinoic Acid Signaling Is Essential for Valvulogenesis by Affecting Endocardial Cushions Formation in Zebrafish Embryos. Zebrafish. 13(1):9-18

Liu, Y., Chen, X., Xu, Q., Gao, X., Tam, P.O., Zhao, K., Zhang, X., Chen, L.J., Jia, W., Zhao, Q., Vollrath, D., Pang, C.P., Zhao, C. (2015) SPP2 Mutations Cause Autosomal Dominant Retinitis Pigmentosa. Scientific Reports. 5:14867

Li, J., Yue, Y., Dong, X., Jia, W., Li, K., Liang, D., Dong, Z., Wang, X., Nan, X., Zhang, Q., Zhao, Q. (2015) Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. The Journal of biological chemistry. 290(16):10216-28

Wei, L., Shen, Y., Xu, F., Hu, F., Harrington, J.K., Targoff, K.L., Min, W. (2015) Imaging complex protein metabolism in live organisms by stimulated Raman scattering microscopy with isotope labeling. ACS Chemical Biology. 10(3):901-8

Xu, T., Zhao, J., Yin, D., Zhao, Q., Dong, B. (2015) High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC Genomics. 16:23

Liu, Y., Chen, X., Qin, B., Zhao, K., Zhao, Q., Staley, J.P., Zhao, C. (2015) Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish. Journal of ophthalmology. 2015:816329

Li, J., Li, K., Dong, X., Liang, D., Zhao, Q. (2014) Ncor1 and Ncor2 Play essential but distinct roles in zebrafish primitive myelopoiesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(12):1544-53

Dong, Z., Dong, X., Jia, W., Cao, S., Zhao, Q. (2014) Improving the efficiency for generation of genome-edited zebrafish by labeling primordial germ cells. The international journal of biochemistry & cell biology. 55:329-34

Chen, X., Liu, Y., Sheng, X., Tam, P.O., Zhao, K., Chen, X., Rong, W., Liu, Y., Liu, X., Pan, X., Chen, L.J., Zhao, Q., Vollrath, D., Pang, C.P., and Zhao, C. (2014) PRPF4 mutations cause autosomal dominant retinitis pigmentosa. Human molecular genetics. 23(11):2926-39

Dong, Z., Ge, J., Xu, Z., Dong, X., Cao, S., Pan, J., Zhao, Q. (2014) Generation of Myostatin b Knockout Yellow Catfish (Tachysurus Fulvidraco) Using Transcription Activator-Like Effector Nucleases. Zebrafish. 11(3):265-74

Xu, T., Zhao, J., Hu, P., Dong, Z., Li, J., Zhang, H., Yin, D., Zhao, Q. (2014) Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage. Toxicology and applied pharmacology. 277:183-91

Li, J., Jia, W., Zhao, Q. (2014) Excessive nitrite affects zebrafish valvulogenesis through yielding too much NO signaling. PLoS One. 9:e92728

He, Q., Wang, L., Wang, F., Wang, C., Tang, C., Li, Q., Li, J., and Zhao, Q. (2013) Microbial fingerprinting detects intestinal microbiota dysbiosis in Zebrafish models with chemically-induced enterocolitis. BMC microbiology. 13:289

Ge, J., Dong, Z., Li, J., Xu, Z., Song, W., Bao, J., Liang, D., Li, J., Li, K., Jia, W., Zhao, M., Cai, Y., Yang, J., Pan, J., and Zhao, Q. (2012) Isolation of yellow catfish beta-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein. Transgenic Research. 21(5):995-1004

Li, J., Hu, P., Li, K., and Zhao, Q. (2012) Identification and Characterization of a Novel Retinoic Acid Response Element in Zebrafish cyp26a1 Promoter. The Anatomical record. 295(2):268-77

Liang, D., Jia, W., Li, J., Li, K., and Zhao, Q. (2012) Retinoic Acid signaling plays a restrictive role in zebrafish primitive myelopoiesis. PLoS One. 7(2):e30865

Chen, Q., Huang, S., Zhao, Q., Chen, R., and Zhang, A. (2011) Expression and function of the Ets transcription factor pea3 during formation of zebrafish pronephros. Pediatric nephrology (Berlin, Germany). 26(3):391-400

Dong, Z., Ge, J., Li, K., Xu, Z., Liang, D., Li, J., Li, J., Jia, W., Li, Y., Dong, X., Cao, S., Wang, X., Pan, J., and Zhao, Q. (2011) Heritable Targeted Inactivation of Myostatin Gene in Yellow Catfish (Pelteobagrus fulvidraco) Using Engineered Zinc Finger Nucleases. PLoS One. 6(12):e28897

Zheng, X., Xu, C., Di Lorenzo, A., Kleaveland, B., Zou, Z., Seiler, C., Chen, M., Cheng, L., Xiao, J., He, J., Pack, M.A., Sessa, W.C., and Kahn, M.L. (2010) CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J. Clin. Invest.. 120(8):2795-2804

Xu, F., Li, K., Tian, M., Hu, P., Song, W., Chen, J., Gao, X., and Zhao, Q. (2009) N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mechanisms of Development. 126(10):771-780

Yin, D., Zhu, H., Hu, P., and Zhao, Q. (2009) Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver. Environmental toxicology and chemistry. 28(3):603-608

Qian, F., Zhang, C., Zhang, Y., He, W., Gao, X., Hu, P., and Guo, Z. (2009) Visible Light Excitable Zn(2+) Fluorescent Sensor Derived from an Intramolecular Charge Transfer Fluorophore and Its in Vitro and in Vivo Application. Journal of the American Chemical Society. 131(4):1460-1468

Hu, P., Tian, M., Bao, J., Xing, G., Gu, X., Gao, X., Linney, E., and Zhao, Q. (2008) Retinoid regulation of the zebrafish cyp26a1 promoter. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3798-3808

Liang, D., Zhang, M., Bao, J., Zhang, L., Xu, X., Gao, X., and Zhao, Q (2008) Expressions of Raldh3 and Raldh4 during zebrafish early development. Gene expression patterns : GEP. 8(4):248-253

Yin, D., Gu, Y., Li, Y., Wang, X., and Zhao, Q. (2006) Pentachlorophenol treatment in vivo elevates point mutation rate in zebrafish p53 gene. Mutation research. 609(1):92-101

Yao, J., Wang, L., Chen, L., Zhang, S., Zhao, Q., Jia, W., and Xue, J. (2006) Cloning and developmental expression of the DEC1 ortholog gene in zebrafish. Gene expression patterns : GEP. 6(8):919-927

Song, W., Zou, Z., Xu, F., Gu, X., Xu, X., and Zhao, Q. (2006) Molecular cloning and expression of a second zebrafish aldehyde dehydrogenase 2 gene (aldh2b). DNA sequence : the journal of DNA sequencing and mapping. 17(4):262-269

Gu, X., Xu, F., Song, W., Wang, X., Hu, P., Yang, Y., Gao, X., and Zhao, Q. (2006) A Novel Cytochrome P450, Zebrafish Cyp26D1, Is Involved in Metabolism of All-trans Retinoic Acid. Molecular endocrinology (Baltimore, Md.). 20(7):1661-1672

Gu, X., Xu, F., Wang, X., Gao, X., and Zhao, Q. (2005) Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development. Gene expression patterns : GEP. 5(6):733-739

Sun, L., Zou, Z., Collodi, P., Xu, F., Xu, X., and Zhao, Q. (2005) Identification and characterization of a second fibronectin gene in zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 24(1):69-77

Zhao, Q., Dobbs-McAuliffe, B., and Linney, E. (2005) Expression of cyp26b1 during zebrafish early development. Gene expression patterns : GEP. 5(3):363-369

Dobbs-McAuliffe, B., Zhao, Q., and Linney, E. (2004) Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. Mechanisms of Development. 121(4):339-350

Liu, X., Zhao, Q., and Collodi, P. (2003) A truncated form of fibronectin is expressed in fish and mammals. Matrix biology : journal of the International Society for Matrix Biology. 22(5):393-396

Zhao, Q., Liu, X., and Collodi, P. (2001) Identification and characterization of a novel fibronectin in zebrafish. Experimental cell research. 268(2):211-219