ZFIN ID: ZDB-LAB-050309-1
Vertebrate Brain Patterning
PI/Director: Schneider-Maunoury, Sylvie
Co-PI / Senior
Laclef, Christine
Contact Person: Schneider-Maunoury, Sylvie
Email: sylvie.schneider-maunoury@snv.jussieu.fr
URL: http://bio-dev.snv.jussieu.fr
Address: Biologie du Developpement CNRS UMR 7622 Universite Pierre et Marie Curie 9 quai St Bernard, Bat C 7eme etage-boite 24 75252 Paris cedex 05, France
Country: France
Phone: 33 (0)1 44 27 21 54
Fax: 33 (0)1 44 27 34 45
Line Designation: pmc

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Our team works on the molecular mechanisms of brain patterning in vertebrate embryos, with two model organisms, zebrafish and mice. Early in vertebrate development the neural plate becomes progressively subdivided into smaller and smaller territories that prefigure the functional organisation of the adult brain. A striking example of this patterning process is the hindbrain, where a segmentation process leads to the formation of 7-8 transient bulges named rhombomeres. This segmentation process sets up the reiterated pattern of brain stem cranial nerves and is involved in patterning and migration of the neural crest, thereby influencing craniofacial morphogenesis. Despite numerous studies already performed, the molecular and cellular mechanisms involved in early brain patterning are far from being totally understood. Our project seeks at better understanding these mechanisms. We analyse the function in neural plate patterning of several genes coding for homeodomain transcription factors, Iroquois genes and vhnf1/Tcf2, and of the Post1 gene, identified recently in our team, that codes for a transmembrane protein of the DCC family.

Stedman, Aline Graduate Student Anselme, Isabelle Technical Staff

Eschstruth, A., Schneider-Maunoury, S., Giudicelli, F. (2019) Creation of zebrafish knock-in reporter lines in the nefma gene by Cas9-mediated homologous recombination. Genesis (New York, N.Y. : 2000). 58(1):e23340
Palha, I.G., Anselme, I., Schneider-Maunoury, S., Giudicelli, F. (2018) An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos. Biology Open. 7(12):
Fassier, C., Fréal, A., Gasmi, L., Delphin, C., Ten Martin, D., De Gois, S., Tambalo, M., Bosc, C., Mailly, P., Revenu, C., Peris, L., Bolte, S., Schneider-Maunoury, S., Houart, C., Nothias, F., Larcher, J.C., Andrieux, A., Hazan, J. (2018) Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics. The Journal of cell biology. 217(5):1719-1738
Breau, M.A., Bonnet, I., Stoufflet, J., Xie, J., De Castro, S., Schneider-Maunoury, S. (2017) Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit. Nature communications. 8:282
Haeussler, M., Schönig, K., Eckert, H., Eschstruth, A., Mianné, J., Renaud, J.B., Schneider-Maunoury, S., Shkumatava, A., Teboul, L., Kent, J., Joly, J.S., Concordet, J.P. (2016) Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR. Genome biology. 17:148
Chen, C., Stedman, A., Havis, E., Anselme, I., Onichtchouk, D., Giudicelli, F., Schneider-Maunoury, S. (2016) Initiation of cyp26a1 Expression in the Zebrafish Anterior Neural Plate by a Novel Cis-Acting Element. PLoS One. 11:e0150639
Baraban, M., Anselme, I., Schneider-Maunoury, S., and Giudicelli, F. (2013) Zebrafish embryonic neurons transport messenger RNA to axons and growth cones in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(40):15726-15734
Mahuzier, A., Gaudé, H.M., Grampa, V., Anselme, I., Silbermann, F., Leroux-Berger, M., Delacour, D., Ezan, J., Montcouquiol, M., Saunier, S., Schneider-Maunoury, S., and Vesque, C. (2012) Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity. The Journal of cell biology. 198(5):927-940
Burcklé, C., Gaudé, H.M., Vesque, C., Silbermann, F., Salomon, R., Jeanpierre, C., Antignac, C., Saunier, S., and Schneider-Maunoury, S. (2011) Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Human molecular genetics. 20(13):2611-27
Fassier, C., Hutt, J.A., Scholpp, S., Lumsden, A., Giros, B., Nothias, F., Schneider-Maunoury, S., Houart, C., and Hazan, J. (2010) Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nature Neuroscience. 13(11):1380-1387
Stedman, A., Lecaudey, V., Havis, E., Anselme, I., Wassef, M., Gilardi-Hebenstreit, P., and Schneider-Maunoury, S. (2009) A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3. Developmental Biology. 327(2):566-577
Wassef, M.A., Chomette, D., Pouilhe, M., Stedman, A., Havis, E., Desmarquet-Trin Dinh, C., Schneider-Maunoury, S., Gilardi-Hebenstreit, P., Charnay, P., and Ghislain, J. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development (Cambridge, England). 135(20):3369-3378
Lokmane, L., Haumaitre, C., Garcia-Villalba, P., Anselme, I., Schneider-Maunoury, S., and Cereghini, S. (2008) Crucial role of vHNF1 in vertebrate hepatic specification. Development (Cambridge, England). 135(16):2777-2786
Lecaudey, V., Ulloa, E., Anselme, I., Stedman, A., Schneider-Maunoury, S., and Pujades C. (2007) Role of the hindbrain in patterning the otic vesicle: A study of the zebrafish vhnf1 mutant. Developmental Biology. 303(1):134-143
Pezeron, G., Anselme, I., Laplante, M., Ellingsen, S., Becker, T.S., Rosa, F.M., Charnay, P., Schneider-Maunoury, S., Mourrain, P., and Ghislain, J. (2006) Duplicate sfrp1 genes in zebrafish: sfrp1a is dynamically expressed in the developing central nervous system, gut and lateral line. Gene expression patterns : GEP. 6(8):835-842
Vesque, C., Anselme, I., Couve, E., Charnay, P., and Schneider-Maunoury, S. (2006) Cloning of vertebrate Protogenin (Prtg) and comparative expression analysis during axis elongation. Developmental dynamics : an official publication of the American Association of Anatomists. 235(10):2836-2844
Havis, E., Anselme, I., and Schneider-Maunoury, S. (2006) Whole embryo chromatin immunoprecipitation protocol for the in vivo study of zebrafish development. Biotechniques. 40(1):34, 36, 38
Lecaudey, V., Anselme, I., Dildrop, R., Ruther, U., and Schneider-Maunoury, S. (2005) Expression of the zebrafish Iroquois genes during early nervous system formation and patterning. The Journal of comparative neurology. 492(3):289-302