ZFIN ID: ZDB-LAB-050228-2
Gothilf Lab
PI/Director: Gothilf, Yoav
Contact Person:
URL: http://www.tau.ac.il/lifesci/departments/neuro/members/gothilf/gothilf.html
Address: Department of Neurobiochemistry Goerge S. Wise Faculty of Life Sciences Tel Aviv University Tel Aviv, 69978 Israel
Country: Israel
Line Designation: tlv

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Geyer, N., Kaminsky, S., Confino, S., Livne, Z.B., Gothilf, Y., Foulkes, N.S., Vallone, D. (2023) Establishment of cell lines from individual zebrafish embryos. Laboratory animals. 57(5):518-528
Elazary, Y., Cheow, K., Cheng, R.K., Ghosh, R., Shainer, I., Wexler, Y., Crasta, K., Gothilf, Y., Jesuthasan, S.J. (2023) Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland. Journal of pineal research. 74(3):e12854
Baniel, A., Ziv, L., Ben-Moshe, Z., Sarig, O., Mohamad, J., Peled, A., Rechavi, G., Gothilf, Y., Sprecher, E. (2022) Cutaneous and Developmental Effects of CARD14 Overexpression in Zebrafish. Biomedicines. 10(12):
Carstensen, M.B., Medvetzky, A., Weinberger, A., Driever, W., Gothilf, Y., Rath, M.F. (2022) Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior. Journal of pineal research. 72(4):e12795
Confino, S., Dor, T., Tovin, A., Wexler, Y., Ben-Moshe Livne, Z., Kolker, M., Pisanty, O., Park, S.K., Geyer, N., Reiter, J., Edvardson, S., Mor-Shaked, H., Elpeleg, O., Vallone, D., Appelbaum, L., Foulkes, N.S., Gothilf, Y. (2022) A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System. International Journal of Molecular Sciences. 23(4):
Ruggiero, G., Ben-Moshe Livne, Z., Wexler, Y., Geyer, N., Vallone, D., Gothilf, Y., Foulkes, N.S. (2021) Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions. Frontiers in molecular neuroscience. 14:718387
Chang, E., Fu, C., Coon, S.L., Alon, S., Bozinoski, M., Breymaier, M., Bustos, D.M., Clokie, S.J., Gothilf, Y., Esnault, C., Iuvone, P.M., Mason, C.E., Ochocinska, M.J., Tovin, A., Wang, C., Xu, P., Zhu, J., Dale, R., Klein, D.C. (2020) Resource: A Multi-species Multi-timepoint Transcriptome Database and Webpage for the Pineal Gland and Retina. Journal of pineal research. 69(3):e12673
Talya, E., Nilli, Z., Yonatan, Z., Berta, L.S., Matan, G., Yoav, G. (2020) Ectopic over expression of kiss1 may compensate for the loss of kiss2. General and comparative endocrinology. 295:113523
Bassi, I., Luzzani, F., Marelli, F., Vezzoli, V., Cotellessa, L., Prober, D.A., Persani, L., Gothilf, Y., Bonomi, M. (2020) Knocking-down of the Prokineticin receptor 2 affects reveals its complex role in the regulation of the hypothalamus-pituitary-gonadal axis in the zebrafish model. Scientific Reports. 10:7632
Zuccarini, G., D'Atri, I., Cottone, E., Mackie, K., Shainer, I., Gothilf, Y., Provero, P., Bovolin, P., Merlo, G.R. (2019) Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. International Journal of Molecular Sciences. 21(1):
Messina, A., Pulli, K., Santini, S., Acierno, J., Känsäkoski, J., Cassatella, D., Xu, C., Casoni, F., Malone, S.A., Ternier, G., Conte, D., Sidis, Y., Tommiska, J., Vaaralahti, K., Dwyer, A., Gothilf, Y., Merlo, G.R., Santoni, F., Niederländer, N.J., Giacobini, P., Raivio, T., Pitteloud, N. (2019) Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism. American journal of human genetics. 106(1):58-70
Shainer, I., Michel, M., Marquart, G.D., Bhandiwad, A.A., Zmora, N., Ben-Moshe Livne, Z., Zohar, Y., Hazak, A., Mazon, Y., Förster, D., Hollander-Cohen, L., Cone, R.D., Burgess, H.A., Gothilf, Y. (2019) Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. Current biology : CB. 29(12):2009-2019.e7
Alon, S., Eisenberg, E., Jacob-Hirsch, J., Rechavi, G., Vatine, G., Toyama, R., Coon, S.L., Klein, D.C., Gothilf, Y. (2019) Corrigendum to: A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland. Bioinformatics (Oxford, England). 35(20):4206
Sloin, H.E., Ruggiero, G., Rubinstein, A., Smadja Storz, S., Foulkes, N.S., Gothilf, Y. (2018) Interactions between the circadian clock and TGF-β signaling pathway in zebrafish. PLoS One. 13:e0199777
Spicer, O.S., Zmora, N., Wong, T.T., Golan, M., Levavi-Sivan, B., Gothilf, Y., Zohar, Y. (2017) The GNIH (Lpxrfa) system's regulation of reproduction in the brain-pituitary axis of the zebrafish (Danio rerio). Biology of reproduction. 96(5):1031-1042
Shainer, I., Buchshtab, A., Hawkins, T.A., Wilson, S.W., Cone, R.D., Gothilf, Y. (2017) Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish. Scientific Reports. 7:44777
Blechman, J., Levkowitz, G., Gothilf, Y. (2017) The not-so-long history of zebrafish research in Israel. The International journal of developmental biology. 61:149-157
Ben-Moshe Livne, Z., Alon, S., Vallone, D., Bayleyen, Y., Tovin, A., Shainer, I., Nisembaum, L.G., Aviram, I., Smadja-Storz, S., Fuentes, M., Falcón, J., Eisenberg, E., Klein, D.C., Burgess, H.A., Foulkes, N.S., Gothilf, Y. (2016) Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. PLoS Genetics. 12:e1006445
Bassi, I., André, V., Marelli, F., Vezzoli, V., Merlo, G.R., Cariboni, A., Persani, L., Gothilf, Y., Bonomi, M. (2016) The zebrafish: an emerging animal model for investigating the hypothalamic regulation of reproduction. Minerva endocrinologica. 41(2):250-65
Howard, S.R., Guasti, L., Ruiz-Babot, G., Mancini, A., David, A., Storr, H.L., Metherell, L.A., Sternberg, M.J., Cabrera, C.P., Warren, H.R., Barnes, M.R., Quinton, R., de Roux, N., Young, J., Guiochon-Mantel, A., Wehkalampi, K., André, V., Gothilf, Y., Cariboni, A., Dunkel, L. (2016) IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. EMBO Molecular Medicine. 8(6):626-42
Rainy, N., Etzion, T., Alon, S., Pomeranz, A., Nisgav, Y., Livnat, T., Bach, M., Gerstner, C.D., Baehr, W., Gothilf, Y., Stiebel-Kalish, H. (2016) Knockdown of unc119c results in visual impairment and early-onset retinal dystrophy in zebrafish. Biochemical and Biophysical Research Communications. 473(4):1211-7
Garaffo, G., Conte, D., Provero, P., Tomaiuolo, D., Luo, Z., Pinciroli, P., Peano, C., D'Atri, I., Gitton, Y., Etzion, T., Gothilf, Y., Gays, D., Santoro, M.M., Merlo, G.R. (2015) The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system. Molecular and cellular neurosciences. 68:103-19
Daya, A., Vatine, G.D., Becker-Cohen, M., Tal-Goldberg, T., Friedmann, A., Gothilf, Y., Du, S.J., and Mitrani-Rosenbaum, S. (2014) Gne depletion during zebrafish development impairs skeletal muscle structure and function. Human molecular genetics. 23(13):3349-61
Ben-Moshe, Z., Alon, S., Mracek, P., Faigenbloom, L., Tovin, A., Vatine, G.D., Eisenberg, E., Foulkes, N.S., and Gothilf, Y. (2014) The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Nucleic acids research. 42(6):3750-67
Ben-Moshe, Z., Foulkes, N.S., Gothilf, Y. (2014) Functional Development of the Circadian Clock in the Zebrafish Pineal Gland. BioMed Research International. 2014:235781
Garaffo, G., Provero, P., Molineris, I., Pinciroli, P., Peano, C., Battaglia, C., Tomaiuolo, D., Etzion, T., Gothilf, Y., Santoro, M., and Merlo, G.R. (2013) Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Frontiers in Experimental Endocrinology. 4:203
Elbaz, I., Foulkes, N.S., Gothilf, Y., and Appelbaum, L. (2013) Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish. Frontiers in neural circuits. 7:9
Smadja Storz, S., Tovin, A., Mracek, P., Alon, S., Foulkes, N.S., and Gothilf, Y. (2013) Casein kinase 1delta activity: a key element in the zebrafish circadian timing system. PLoS One. 8(1):e54189
Dresner, E., Malishkevich, A., Arviv, C., Leibman Barak, S., Alon, S., Ofir, R., Gothilf, Y., and Gozes, I. (2012) Novel Evolutionary-Conserved Role for the ADNP Protein Family that is Important for Erythropoiesis. The Journal of biological chemistry. 287(48):40173-40185
Stiebel-Kalish, H., Reich, E., Rainy, N., Vatine, G., Nisgav, Y., Tovar, A., Gothilf, Y., and Bach, M. (2012) Gucy2f zebrafish knockdown – a model for Gucy2d-related leber congenital amaurosis. European journal of human genetics : EJHG. 20(8):884-889
Idda, M.L., Bertolucci, C., Vallone, D., Gothilf, Y., Sánchez-Vázquez, F.J., and Foulkes, N.S. (2012) Circadian clocks: Lessons from fish. Progress in brain research. 199:41-57
Mracek, P., Santoriello, C., Idda, M.L., Pagano, C., Ben-Moshe, Z., Gothilf, Y., Vallone, D., and Foulkes, N.S. (2012) Regulation of per and cry Genes Reveals a Central Role for the D-Box Enhancer in Light-Dependent Gene Expression. PLoS One. 7(12):e51278
Tovin, A., Alon, S., Ben-Moshe, Z., Mracek, P., Vatine, G., Foulkes, N.S., Jacob-Hirsch, J., Rechavi, G., Toyama, R., Coon, S.L., Klein, D.C., Eisenberg, E., and Gothilf, Y. (2012) Systematic Identification of Rhythmic Genes Reveals camk1gb as a New Element in the Circadian Clockwork. PLoS Genetics. 8(12):e1003116
Vatine, G., Vallone, D., Gothilf, Y., and Foulkes, N.S. (2011) It's time to swim! Zebrafish and the circadian clock. FEBS letters. 585(10):1485-1494
Ben-Moshe, Z., Vatine, G., Alon, S., Tovin, A., Mracek, P., Foulkes, N.S., and Gothilf, Y. (2010) Multiple PAR and E4BP4 bZIP transcription factors in zebrafish: diverse spatial and temporal expression patterns. Chronobiology International. 27(8):1509-1531
Palevitch, O., Abraham, E., Borodovsky, N., Levkowitz, G., Zohar, Y., and Gothilf, Y. (2010) Cxcl12a-Cxcr4b signaling is important for proper development of the forebrain GnRH system in zebrafish. General and comparative endocrinology. 165(2):262-268
Abraham, E., Palevitch, O., Gothilf, Y., and Zohar, Y. (2010) Targeted Gonadotropin-Releasing Hormone-3 Neuron Ablation in Zebrafish: Effects on Neurogenesis, Neuronal Migration, and Reproduction. Endocrinology. 151(1):332-340
Abraham, E., Palevitch, O., Gothilf, Y., and Zohar, Y. (2009) The zebrafish as a model system for forebrain GnRH neuronal development. General and comparative endocrinology. 164(2-3):151-160
Vatine, G., Vallone, D., Appelbaum, L., Mracek, P., Ben-Moshe, Z., Lahiri, K., Gothilf, Y., and Foulkes, N.S. (2009) Light directs zebrafish period2 expression via conserved D and E boxes. PLoS Biology. 7(10):e1000223
Toyama, R., Chen, X., Jhawar, N., Aamar, E., Epstein, J., Reany, N., Alon, S., Gothilf, Y., Klein, D.C., and Dawid, I.B. (2009) Transcriptome analysis of the zebrafish pineal gland. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1813-1826
Alon, S., Eisenberg, E., Jacob-Hirsch, J., Rechavi, G., Vatine, G., Toyama, R., Coon, S.L., Klein, D.C., and Gothilf, Y. (2009) A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland. Bioinformatics (Oxford, England). 25(5):559-562
Palevitch, O., Abraham, E., Borodovsky, N., Levkowitz, G., Zohar, Y., and Gothilf, Y. (2009) Nasal embryonic LHRH factor plays a role in the developmental migration and projection of gonadotropin-releasing hormone 3 neurons in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):66-75
Abraham, E., Palevitch, O., Ijiri, S., Du, S.J., Gothilf, Y., and Zohar, Y. (2008) Early Development of Gonadotrophin-Releasing Hormone-I Neurones and the Role of GnRH-I as an Autocrine Migration Factor. Journal of neuroendocrinology. 20(3):394-405
Palevitch, O., Kight, K., Abraham, E., Wray, S., Zohar, Y., and Gothilf, Y. (2007) Ontogeny of the GnRH systems in zebrafish brain: in situ hybridization and promoter-reporter expression analyses in intact animals. Cell and tissue research. 327(2):313-322
Zilberman-Peled, B., Appelbaum, L., Vallone, D., Foulkes, N.S., Anava, S., Anzulovich, A., Coon, S.L., Klein, D.C., Falcon, J., Ron, B., and Gothilf, Y. (2007) Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. Journal of neuroendocrinology. 19(1):46-53
Ziv, L., Tovin, A., Strasser, D., and Gothilf, Y. (2007) Spectral sensitivity of melatonin suppression in the zebrafish pineal gland. Experimental Eye Research. 84(1):92-99
Appelbaum, L., and Gothilf, Y. (2006) Mechanism of pineal-specific gene expression: The role of E-box and photoreceptor conserved elements. Molecular and Cellular Endocrinology. 252(1-2):27-33
Vuilleumier, R., Besseau, L., Boeuf, G., Piparelli, A., Gothilf, Y., Gehring, W.G., Klein, D.C., and Falcon, J. (2006) Starting the Zebrafish Pineal Circadian Clock with a Single Photic Transition. Endocrinology. 147(5):2273-2279
Appelbaum, L., Vallone, D., Anzulovich, A., Ziv, L., Tom, M., Foulkes, N.S., and Gothilf, Y. (2006) Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock. Journal of molecular endocrinology. 36(2):337-347
Ziv, L., and Gothilf, Y. (2006) Circadian time-keeping during early stages of development. Proceedings of the National Academy of Sciences of the United States of America. 103(11):4146-4151
Zilberman-Peled, B., Ron, B., Gross, A., Finberg, J.P., and Gothilf, Y. (2006) A possible new role for fish retinal serotonin-N-acetyltransferase-1 (AANAT1): Dopamine metabolism. Brain research. 1073-1074:220-228
Ziv, L., and Gothilf, Y. (2006) Period2 expression pattern and its role in the development of the pineal circadian clock in zebrafish. Chronobiology International. 23(1):101-112
Ziv, L., Levkovitz, S., Toyama, R., Falcon, J., and Gothilf, Y. (2005) Functional Development of the Zebrafish Pineal Gland: Light-Induced Expression of Period2 is Required for Onset of the Circadian Clock. Journal of neuroendocrinology. 17(5):314-320
Appelbaum, L. Anzulovich, A., Baler, R., and Gothilf, Y. (2005) Homeobox-clock protein interaction in zebrafish: A shared mechanism for pineal-specific and circadian gene expression. The Journal of biological chemistry. 280(12):11544-11551
Zilberman-Peled, B., Benhar, I., Coon, S.L., Ron, B., and Gothilf, Y. (2004) Duality of serotonin-N-acetyltransferase in the gilthead seabream (Sparus aurata): molecular cloning and characterization of recombinant enzymes. General and comparative endocrinology. 138(2):139-147
Appelbaum, L., Toyama, R., Dawid, I.B., Klein, D.C., Baler, R., and Gothilf, Y. (2004) Zebrafish serotonin-N-acetyltransferase-2 gene regulation: Pineal-restrictive downstream module (PRDM) contains a functional E-box and three photoreceptor conserved elements. Molecular endocrinology (Baltimore, Md.). 18(5):1210-1221
Falcon, J., Gothilf, Y., Coon, S.L., Boeuf, G., and Klein, D.C. (2003) Genetic, temporal and developmental differences between melatonin rhythm generating systems in the teleost fish pineal organ and retina. Journal of neuroendocrinology. 15(4):378-382
Gothilf, Y., Toyama, R., Coon, S.L., Du, S.-J., Dawid, I.B., and Klein, D.C. (2002) Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 225(3):241-249
Gothilf, Y., Coon, S.L., Toyama, R., Chitnis, A., Namboodiri, M.A.A., and Klein, D.C. (1999) Zebrafish serotonin N-acetyltransferase-2: marker for development of pineal photoreceptors and circadian clock function. Endocrinology. 140(10):4895-4903