ZFIN ID: ZDB-LAB-030128-3
Voigt Lab
PI/Director: Voigt, Mark
Co-PI / Senior
Cox, Jane
Contact Person: Voigt, Mark
Email: voigtm@slu.edu
URL: http://medschool.slu.edu/pharmphys/fac/voigt/voigt.shtml
Address: Department of Pharmacological and Physiological Science St. Louis University School of Medicine 1402 South Grand Boulevard St. Louis, MO 63104 USA
Country: United States
Phone: (314) 977-6445
Fax: (314) 977-6411
Line Designation: sl

Show all 9 genomic features

The research in our group focuses on mechanisms by which signal transduction occurs within neurons, with particular emphasis placed on the cellular and molecular biology of receptor genes and their products. Our efforts are centered on a class of receptors that mediate the signaling actions of the purine ATP.

ATP is released by cells into the extracellular environment, where it can act upon transmembrane receptors to influence intracellular events. These purinergic receptors for ATP, based on structural and functional features, have been subdivided into two classes- the G-protein coupled receptors (P2Y) and the ligand-gated channels (P2X). It is the P2X receptor class that is the focus of our work. P2X receptors are non-selective cation channels that exhibit appreciable Ca2+ permeability and are present in most tissues of the body. These receptors are oligomeric proteins, and to date, seven different mammalian genes encoding P2X subunits have been identified. Although the various subunits exhibit a widespread distribution throughout the body, the lack of useful pharmacological tools has resulted in a poor understanding of the physiological roles that these receptors play.

Our lab is pursuing two investigative avenues into the function of these receptors. The first uses a molecular and biochemical approach to understand cellular function by identifying the structural domains of these proteins, whereas the second approach exploits the zebrafish (Danio) model system to gain an understanding of the physiological functions that these receptors are involved in.

Recently, we have identified and characterized, in a preliminary fashion, nine P2X subunit genes in the zebrafish. A number of these genes are expressed in the sensory neurons of the embryonic fish, and our current studies are focused on examining a)the composition of P2X receptors in the various subytpes of sensory neurons, b)their functional properties and c)their role in the development and function of the zebrafish sensory nervous system.


Cox, J.A., Voigt, M.M. (2019) The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain. Frontiers in neural circuits. 13:14
Allen, J.R., Bhattacharyya, K.D., Asante, E., Almadi, B., Schafer, K., Davis, J., Cox, J., Voigt, M., Viator, J.A., Chandrasekhar, A. (2017) Role of branchiomotor neurons in controlling food intake of zebrafish larvae. Journal of neurogenetics. 31(3):128-137
Cox, J.A., Zhang, B., Pope, H.M., Voigt, M.M. (2016) Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish. PLoS One. 11:e0148726
Pope, H.M., Voigt, M.M. (2014) Peripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafish. PLoS One. 9:e103283
Cox, J.A., Lamora, A., Johnson, S.L., and Voigt, M.M. (2014) Novel role for carbamoyl phosphate synthetase 2 in cranial sensory circuit formation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 33C:41-48
Chen, W., Tseng, X., Lin, G., Schreiner, A., Chen, H., Voigt, M.M., Yuh, C., Wu, J., Huang, S.S., and Huang, J. (2013) The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish. CellBio. 2(4):228-247
Cox, J.A., McAdow, A.R., Dinitz, A.E., McCallion, A.S., Johnson, S.L., and Voigt, M.M. (2011) A zebrafish SKIV2L2-enhancer trap line provides a useful tool for the study of peripheral sensory circuit development. Gene expression patterns : GEP. 11(7):409-14
Cox, J.A., Lamora, A., Johnson, S.L., and Voigt, M.M. (2011) Diverse mechanisms for assembly of branchiomeric nerves. Developmental Biology. 357(2):305-17
Kucenas, S., Cox, J.A., Soto, F., Lamora, A., and Voigt, M.M. (2009) Ectodermal P2X receptor function plays a pivotal role in craniofacial development of the zebrafish. Purinergic signalling. 5(3):395-407
Lamora, A., and Voigt, M.M. (2009) Cranial sensory ganglia neurons require intrinsic N-cadherin function for guidance of afferent fibers to their final targets. Neuroscience. 159(3):1175-1184
Kucenas, S., Soto, F., Cox, J.A., and Voigt, M.M. (2006) Selective labeling of central and peripheral sensory neurons in the developing zebrafish using P2X(3) receptor subunit transgenes. Neuroscience. 138(2):641-652
Cox, J.A., Kucenas, S., and Voigt, M.M. (2005) Molecular characterization and embryonic expression of the family of N-methyl-D-aspartate receptor subunit genes in the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 234(3):756-766
Kucenas, S., Li, Z., Cox, J.A., Egan, T.M., and Voigt, M.M. (2003) Molecular characterization of the zebrafish P2X receptor subunit gene family. Neuroscience. 121(4):935-945
Diaz-Hernandez, M., Cox, J.A., Migita, K., Haines, W., Egan, T.M., and Voigt, M.M (2002) Cloning and characterization of two novel zebrafish P2X receptor subunits. Biochemical and Biophysical Research Communications. 295(4):849-853
Egan, T.M., Cox, J.A., and Voigt, M.M. (2000) Molecular cloning and functional characterization of the zebrafish ATP-gated ionotropic receptor P2X3 subunit. FEBS letters. 475(3):287-290