ZFIN ID: ZDB-LAB-030114-1
Burdine Lab
PI/Director: Burdine, Rebecca
Contact Person: Burdine, Rebecca
Email: rburdine@princeton.edu
URL: http://www.princeton.edu/molbio/burdine/
Address: Department of Molecular Biology Moffet Lab 433 Princeton University Washington Road Princeton, NJ 08544-1014 USA
Country: United States
Phone: (609) 258-5782
Fax: (609) 258-6730
Line Designation: pr


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 8 genomic features


STATEMENT OF RESEARCH INTERESTS
Nodal Signaling in Left-Right Patterning - We are interested in determining when and where this pathway is required for proper left-right patterning in the brain and viscera. Our recent work demonstrates a previously unrecognized role for the essential Nodal co-factor, one-eyed pinhead, in the midline for patterning to occur in the lateral plate mesoderm. We are currently exploring when and where Nodal signaling is required for left-right patterning in the brain.

Asymmetric Organ Morphogenesis - How an organ obtains its final asymmetric position is not understood in any organism. We are currently cloning zebrafish mutants where organs fail to become asymmetric to understand this process. For example, in these mutants the pancreas remains in the midline and does not become positioned on the right. We are also using GFP transgenic fish to visualize morphogenesis of asymmetric organs in the living embryo.

Cyst formation in the Pronephros - Many of the mutants we currently study have both left-right patterning defects and form cysts in the pronephros. We are interested in understanding the cell biology of cyst formation and the links between cyst formation and left-right patterning.


LAB MEMBERS
Jaffe, Kimberly Post-Doc Okabe, Noriko Post-Doc Baker, Kari Graduate Student
Lin, Shin-Yi Graduate Student Schottenfeld, Jodi Graduate Student Slagle, Christopher Graduate Student
Sullivan-Brown, Jessica Graduate Student Xu, Bo Graduate Student Bosco, Derrick Fish Facility Staff
Agyemang, Amanda Carter, Stuart McAllister, Heather


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Landin, J., Hovey, D., Xu, B., Lagman, D., Zettergren, A., Larhammar, D., Kettunen, P., Westberg, L. (2020) Oxytocin Receptors Regulate Social Preference in Zebrafish. Scientific Reports. 10:5435
Patel, A.L., Yeung, E., McGuire, S.E., Wu, A.Y., Toettcher, J.E., Burdine, R.D., Shvartsman, S.Y. (2019) Optimizing photoswitchable MEK. Proceedings of the National Academy of Sciences of the United States of America. 116(51):25756-25763
Grimes, D.T., Patterson, V.L., Luna-Arvizu, G., Schottenfeld-Roames, J., Irons, Z.H., Burdine, R.D. (2019) Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish. Developmental Biology. 459(2):79-86
Steimle, J.D., Rankin, S.A., Slagle, C.E., Bekeny, J., Rydeen, A.B., Chan, S.S., Kweon, J., Yang, X.H., Ikegami, K., Nadadur, R.D., Rowton, M., Hoffmann, A.D., Lazarevic, S., Thomas, W., Boyle Anderson, E.A.T., Horb, M.E., Luna-Zurita, L., Ho, R.K., Kyba, M., Jensen, B., Zorn, A.M., Conlon, F.L., Moskowitz, I.P. (2018) Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.. Proceedings of the National Academy of Sciences of the United States of America. 115(45):E10615-E10624
Harris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, D.T., Suzuki, M., Burdine, R.D., Cong, F., Koo, B.K., Clevers, H., Stévant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A., McElreavey, K., Greenfield, A. (2018) ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling. Proceedings of the National Academy of Sciences of the United States of America. 115(21):5474-5479
Pelliccia, J.L., Jindal, G.A., Burdine, R.D. (2017) Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning. eLIFE. 6
Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000
Jindal, G.A., Goyal, Y., Humphreys, J.M., Yeung, E., Tian, K., Patterson, V.L., He, H., Burdine, R.D., Shvartsman, S.Y., Goldsmith, E.J. (2017) How activating mutations affect MEK1 regulation and function. The Journal of biological chemistry. 292(46):18814-18820
Goyal, Y., Jindal, G.A., Pelliccia, J.L., Yamaya, K., Yeung, E., Futran, A.S., Burdine, R.D., Schüpbach, T., Shvartsman, S.Y. (2017) Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nature Genetics. 49(3):465-469
Jindal, G.A., Goyal, Y., Yamaya, K., Futran, A.S., Kountouridis, I., Balgobin, C.A., Schüpbach, T., Burdine, R.D., Shvartsman, S.Y. (2017) In vivo severity ranking of Ras pathway mutations associated with developmental disorders. Proceedings of the National Academy of Sciences of the United States of America. 114(3):510-515
Grant, M.G., Patterson, V.L., Grimes, D.T., Burdine, R.D. (2017) Modeling Syndromic Congenital Heart Defects in Zebrafish. Current topics in developmental biology. 124:1-40
Burdine, R.D., Grimes, D.T. (2016) Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 371(1710)
Zhang, Y., Zang, Q., Xu, B., Zheng, W., Ban, R., Zhang, H., Yang, Y., Hao, Q., Iqbal, F., Li, A., Shi, Q. (2016) IsomiR Bank: a research resource for tracking IsomiRs. Bioinformatics (Oxford, England). 32(13):2069-71
Grimes, D.T., Boswell, C.W., Morante, N.F., Henkelman, R.M., Burdine, R.D., Ciruna, B. (2016) Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science (New York, N.Y.). 352:1341-4
Jaffe, K.M., Grimes, D.T., Schottenfeld-Roames, J., Werner, M.E., Ku, T.J., Kim, S.K., Pelliccia, J.L., Morante, N.F., Mitchell, B.J., Burdine, R.D. (2016) c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Reports. 14(8):1841-9
Jindal, G.A., Goyal, Y., Burdine, R.D., Rauen, K.A., Shvartsman, S.Y. (2015) RASopathies: unraveling mechanisms with animal models. Disease models & mechanisms. 8:769-82
Chen, X., Xu, B., Han, X., Mao, Z., Chen, M., Du, G., Talbot, P., Wang, X., Xia, Y. (2015) The effects of triclosan on pluripotency factors and development of mouse embryonic stem cells and zebrafish. Archives of toxicology. 89(4):635-46
Kim, C.K., Miri, A., Leung, L.C., Berndt, A., Mourrain, P., Tank, D.W., Burdine, R.D. (2014) Prolonged, brain-wide expression of nuclear-localized GCaMP3 for functional circuit mapping. Frontiers in neural circuits. 8:138
Larhammar, D., Xu, B., and Bergqvist, C.A. (2014) Unexpected multiplicity of QRFP receptors in early vertebrate evolution. Frontiers in neuroscience. 8:337
Hjeij, R., Onoufriadis, A., Watson, C.M., Slagle, C.E., Klena, N.T., Dougherty, G.W., Kurkowiak, M., Loges, N.T., Diggle, C.P., Morante, N.F., Gabriel, G.C., Lemke, K.L., Li, Y., Pennekamp, P., Menchen, T., Konert, F., Marthin, J.K., Mans, D.A., Letteboer, S.J., Werner, C., Burgoyne, T., Westermann, C., Rutman, A., Carr, I.M., O'Callaghan, C., Moya, E., Chung, E.M., UK10K Consortium, Sheridan, E., Nielsen, K.G., Roepman, R., Bartscherer, K., Burdine, R.D., Lo, C.W., Omran, H., Mitchison, H.M. (2014) CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation. American journal of human genetics. 95:257-274
Tarkar, A., Loges, N.T., Slagle, C.E., Francis, R., Dougherty, G.W., Tamayo, J.V., Shook, B., Cantino, M., Schwartz, D., Jahnke, C., Olbrich, H., Werner, C., Raidt, J., Pennekamp, P., Abouhamed, M., Hjeij, R., Köhler, G., Griese, M., Li, Y., Lemke, K., Klena, N., Liu, X., Gabriel, G., Tobita, K., Jaspers, M., Morgan, L.C., Shapiro, A.J., Letteboer, S.J., Mans, D.A., Carson, J.L., Leigh, M.W., Wolf, W.E., Chen, S., Lucas, J.S., Onoufriadis, A., Plagnol, V., Schmidts, M., Boldt, K., UK10K., Roepman, R., Zariwala, M.A., Lo, C.W., Mitchison, H.M., Knowles, M.R., Burdine, R.D., Loturco, J.J., and Omran, H. (2013) DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nature Genetics. 45(9):995-1003
Sundström, G., Larsson, T.A., Xu, B., Heldin, J., and Larhammar, D. (2013) Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b. Frontiers in neuroscience. 7:29
Lenhart, K.F., Holtzman, N.G., Williams, J.R., and Burdine, R.D. (2013) Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left-Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry. PLoS Genetics. 9(1):e1003109
Panizzi, J.R., Becker-Heck, A., Castleman, V.H., Al-Mutairi, D.A., Liu, Y., Loges, N.T., Pathak, N., Austin-Tse, C., Sheridan, E., Schmidts, M., Olbrich, H., Werner, C., Häffner, K., Hellman, N., Chodhari, R., Gupta, A., Kramer-Zucker, A., Olale, F., Burdine, R.D., Schier, A.F., O'Callaghan, C., Chung, E.M., Reinhardt, R., Mitchison, H.M., King, S.M., Omran, H., and Drummond, I.A. (2012) CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nature Genetics. 44(6):714-719
Lenhart, K.F., Lin, S.Y., Titus, T.A., Postlethwait, J.H., Burdine, R.D. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development (Cambridge, England). 138(20):4405-4410
Slagle, C.E., Aoki, T., and Burdine, R.D. (2011) Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin. PLoS Genetics. 7(5):e1002072
Fogelgren, B., Lin, S.Y., Zuo, X., Jaffe, K.M., Park, K.M., Reichert, R.J., Bell, P.D., Burdine, R.D., and Lipschutz, J.H. (2011) The Exocyst Protein Sec10 Interacts with Polycystin-2 and Knockdown Causes PKD-Phenotypes. PLoS Genetics. 7(4):e1001361
Miri, A., Daie, K., Burdine, R.D., Aksay, E., and Tank, D.W. (2011) Regression-based identification of behavior-encoding neurons during large scale optical imaging of neural activity at cellular resolution. Journal of neurophysiology. 105(2):964-980
Becker-Heck, A., Zohn, I.E., Okabe, N., Pollock, A., Lenhart, K.B., Sullivan-Brown, J., McSheene, J., Loges, N.T., Olbrich, H., Haeffner, K., Fliegauf, M., Horvath, J., Reinhardt, R., Nielsen, K.G., Marthin, J.K., Baktai, G., Anderson, K.V., Geisler, R., Niswander, L., Omran, H., and Burdine, R.D. (2011) The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nature Genetics. 43(1):79-84
Sullivan-Brown, J., Bisher, M.E., and Burdine, R.D. (2011) Embedding, serial sectioning and staining of zebrafish embryos using JB-4 resin. Nature Protocols. 6(1):46-55
Jaffe, K.M., Thiberge, S.Y., Bisher, M.E., and Burdine, R.D. (2010) Imaging Cilia in Zebrafish. Methods in cell biology. 97C:415-435
Serluca, F.C., Xu, B., Okabe, N., Baker, K., Lin, S.Y., Sullivan-Brown, J., Konieczkowski, D.J., Jaffe, K.M., Bradner, J.M., Fishman, M.C., and Burdine, R.D. (2009) Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development (Cambridge, England). 136(10):1621-1631
Okabe, N., Xu, B., and Burdine, R.D. (2008) Fluid dynamics in zebrafish Kupffer's vesicle. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3602-3612
Baker, K., Holtzman, N.G., and Burdine, R.D. (2008) Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. Proceedings of the National Academy of Sciences of the United States of America. 105(37):13924-13929
Weber, S., Taylor, J.C., Winyard, P., Baker, K.F., Sullivan-Brown, J., Schild, R., Knüppel, T., Zurowska, A.M., Caldas-Alfonso, A., Litwin, M., Emre, S., Ghiggeri, G.M., Bakkaloglu, A., Mehls, O., Antignac, C., Schaefer, F., and Burdine, R.D. (2008) SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development. Journal of the American Society of Nephrology : JASN. 19(5):891-903
Sullivan-Brown, J., Schottenfeld, J., Okabe, N., Hostetter, C.L., Serluca, F.C., Thiberge, S.Y., and Burdine, R.D. (2008) Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. Developmental Biology. 314(2):261-275
Schötz, E.M., Burdine, R.D., Jülicher, F., Steinberg, M.S., Heisenberg, C.P., and Foty, R.A. (2008) Quantitative differences in tissue surface tension influence zebrafish germ layer positioning. HFSP Journal. 2(1):42-56
Schottenfeld, J. (2008) The role of PKD2 and C21ORF59 in patterning the left-right axis of the zebrafish embryo. Ph.D. Thesis. :136p
Fan, X., Hagos, E.G., Xu, B., Sias, C., Kawakami, K., Burdine, R.D., and Dougan, S.T. (2007) Nodal signals mediate interactions between the extra-embryonic and embryonic tissues in zebrafish. Developmental Biology. 310(2):363-378
Schottenfeld, J., Sullivan-Brown, J., and Burdine, R.D. (2007) Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw. Development (Cambridge, England). 134(8):1605-1615
Lin, S.Y., and Burdine, R.D. (2005) Brain asymmetry: switching from left to right. Current biology : CB. 15(9):R343-345
Dutta, S., Dietrich, J.E., Aspock, G., Burdine, R.D., Schier, A., Westerfield, M., and Varga, Z.M. (2005) pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development (Cambridge, England). 132(7):1579-1590
Hostetter, C.L., Sullivan-Brown, J.L., and Burdine, R.D. (2003) Zebrafish pronephros: A model for understanding cystic kidney disease. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):514-522
de la Cruz, J.M., Bamford, R.N., Burdine, R.D., Roessler, E., Barkovich, A.J., Donnai, D., Schier, A.F., and Muenke, M. (2002) A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects. Human genetics. 110(5):422-428
Bamford, R.N., Roessler, E., Burdine, R.D., Saplakoglu, U., de la Cruz, J., Splitt, M., Towbin, J., Bowers, P., Marino, B., Schier, A.F., Shen, M.M., Muenke, M., and Casey, B. (2000) Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Nature Genetics. 26(3):365-369
Concha, M.L., Burdine, R.D., Russell, C., Schier, A.F., and Wilson, S.W. (2000) A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain. Neuron. 28(2):399-409
Burdine, R.D. and Schier, A.F. (2000) Conserved and divergent mechanisms in left-right axis formation. Genes & Development. 14(7):763-776
Yan, Y.T., Gritsman, K., Ding, J., Burdine, R.D., Corrales, J.D., Price, S.M., Talbot, W.S., Schier, A.F., and Shen, M.M. (1999) Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes & Development. 13(19):2527-2537