ZFIN ID: ZDB-LAB-010829-2
Hibi Lab
PI/Director: Hibi, Masahiko
Co-PI / Senior
Researcher:		 Hashimoto, Hisashi
Shimizu, Takashi
Contact Person: Hibi, Masahiko
Email: hibi@bio.nagoya-u.ac.jp
URL:
Address: Bioscience and Biotechnology Center Nagoya University Furo-cho, Chikusa-ku Nagoya, Aichi 464-8601 Japan
Country: United States
Phone: 81-52-789-5198
Fax: 81-52-789-5053
Line Designation: nub


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 25 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Nagao, Yusuke Post-Doc Takeuchi, Miki Post-Doc Hino, Hiromu Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Hibi, M., Matsuda, K., Takeuchi, M., Shimizu, T., Murakami, Y. (2017) Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum. Development, Growth & Differentiation. 59(4):228-243
Yun, U.J., Sung, J.Y., Park, S.Y., Ye, S.K., Shim, J., Lee, J.S., Hibi, M., Bae, Y.K., Kim, Y.N. (2017) Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway. Cell Death & Disease. 8:e2621
Song, K.H., Woo, S.R., Chung, J.Y., Lee, H.J., Oh, S.J., Hong, S.O., Shim, J., Kim, Y.N., Rho, S.B., Hong, S.M., Cho, H., Hibi, M., Bae, D.J., Kim, S.Y., Kim, M.G., Kim, T.W., Bae, Y.K. (2017) REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. Cell Death & Disease. 8:e2536
Chiba, A., Watanabe-Takano, H., Terai, K., Fukui, H., Miyazaki, T., Uemura, M., Hashimoto, H., Hibi, M., Fukuhara, S., Mochizuki, N. (2016) Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish. Development (Cambridge, England). 144(2):334-344
Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2016) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology.
Scalise, K., Shimizu, T., Hibi, M., Sawtell, N.B. (2016) Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish. Journal of neurophysiology. 116(5):2067-2080
Kawakami, K., Asakawa, K., Hibi, M., Itoh, M., Muto, A., Wada, H. (2016) Gal4 Driver Transgenic Zebrafish: Powerful Tools to Study Developmental Biology, Organogenesis, and Neuroscience. Advances in genetics. 95:65-87
Kim, J.D., Park, K.E., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., Fukamizu, A. (2015) PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination. Science advances. 1:e1500615
Takeuchi, M., Fuse, Y., Watanabe, M., Andrea, C.S., Takeuchi, M., Nakajima, H., Ohashi, K., Kaneko, H., Kobayashi-Osaki, M., Yamamoto, M., Kobayashi, M. (2015) LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. Proceedings of the National Academy of Sciences of the United States of America. 112(45):13922-7
Takeuchi, M., Yamaguchi, S., Yonemura, S., Kakiguchi, K., Sato, Y., Higashiyama, T., Shimizu, T., Hibi, M. (2015) Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. PLoS Genetics. 11:e1005587
Takeuchi, M., Matsuda, K., Yamaguchi, S., Asakawa, K., Miyasaka, N., Lal, P., Yoshihara, Y., Koga, A., Kawakami, K., Shimizu, T., Hibi, M. (2015) Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry. Developmental Biology. 397(1):1-17
Goda, M., Kelsh, R.N., Hashimoto, H. (2014) Taking striping up a notch. Pigment cell & melanoma research. 27:688-9
Kimura, T., Nagao, Y., Hashimoto, H., Yamamoto-Shiraishi, Y., Yamamoto, S., Yabe, T., Takada, S., Kinoshita, M., Kuroiwa, A., and Naruse, K. (2014) Leucophores are similar to xanthophores in their specification and differentiation processes in medaka. Proc. Natl. Acad. Sci. USA. 111(20):7343-7348
Kwon, H.B., Fukuhara, S., Asakawa, K., Ando, K., Kashiwada, T., Kawakami, K., Hibi, M., Kwon, Y.G., Kim, K.W., Alitalo, K., and Mochizuki, N. (2013) The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish. Development (Cambridge, England). 140(19):4081-4090
Yanicostas, C., Barbieri, E., Hibi, M., Brice, A., Stevanin, G., and Soussi-Yanicostas, N. (2012) Requirement for zebrafish ataxin-7 in differentiation of photoreceptors and cerebellar neurons. PLoS One. 7(11):e50705
Kuscha, V., Frazer, S.L., Dias, T.B., Hibi, M., Becker, T., and Becker, C.G. (2012) Lesion-induced generation of interneuron cell types in specific dorso-ventral domains in the spinal cord of adult zebrafish. The Journal of comparative neurology. 520(16):3604-3616
Tran, L.D., Hino, H., Quach, H., Lim, S., Shindo, A., Mimori-Kiyosue, Y., Mione, M., Ueno, N., Winkler, C., Hibi, M., and Sampath, K. (2012) Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish. Development (Cambridge, England). 139(19):3644-3652
Hashimoto, M., and Hibi, M. (2012) Development and evolution of cerebellar neural circuits. Development, Growth & Differentiation. 54(3):373-389
Imai, H., Oomiya, Y., Kikkawa, S., Shoji, W., Hibi, M., Terashima, T., and Katsuyama, Y. (2012) Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period. Development, Growth & Differentiation. 54(2):253-263
Hattori, M., Hashimoto, H., Bubenshchikova, E., and Wakamatsu, Y. (2011) Nuclear Transfer of Embryonic Cell Nuclei to Non-enucleated Eggs in Zebrafish, Danio rerio. International journal of biological sciences. 7(4):460-468
Matsuda, Y., Ito, Y., Hashimoto, H., Yokoi, H., and Suzuki, T. (2011) Detection of vitellogenin incorporation into zebrafish oocytes by FITC fluorescence. Reproductive Biology and Endocrinolgy. 9:45
Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y. (2011) Function of strawberry notch Family Genes in the Zebrafish Brain Development. The Kobe journal of medical sciences. 56(5):E220-E230
Hibi, M., and Shimizu, T. (2011) Development of the cerebellum and cerebellar neural circuits. Developmental Neurobiology. 72(3):282-301
Tanabe, K., Kani, S., Shimizu, T., Bae, Y.K., Abe, T., and Hibi, M. (2010) Atypical protein kinase C regulates primary dendrite specification of cerebellar purkinje cells by localizing Golgi apparatus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(50):16983-16992
Kani, S., Bae, Y.K., Shimizu, T., Tanabe, K., Satou, C., Parsons, M.J., Scott, E., Higashijima, S.I., and Hibi, M. (2010) Proneural gene-linked neurogenesis in zebrafish cerebellum. Developmental Biology. 343(1-2):1-17
Iida, A., Sakaguchi, K., Sato, K., Sakurai, H., Nishimura, D., Iwaki, A., Takeuchi, M., Kobayashi, M., Misaki, K., Yonemura, S., Kawahara, A., and Sehara-Fujisawa, A. (2010) Metalloprotease-dependent onset of blood circulation in zebrafish. Current biology : CB. 20(12):1110-1116
Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y. (2010) Expression of strawberry notch family genes during zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 239(6):1789-1796
Nojima, H., Rothhämel, S., Shimizu, T., Kim, C.H., Yonemura, S., Marlow, F.L., and Hibi, M. (2010) Syntabulin, a motor protein linker, controls dorsal determination. Development (Cambridge, England). 137(6):923-933
Takeuchi, M., Kaneko, H., Nishikawa, K., Kawakami, K., Yamamoto, M., and Kobayashi, M. (2010) Efficient transient rescue of hematopoietic mutant phenotypes in zebrafish using Tol2-mediated transgenesis. Development, Growth & Differentiation. 52(2):245-250
Bae, Y.K., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S.I., and Hibi, M. (2009) Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Developmental Biology. 330(2):406-426
Sawatari, E., Hashimoto, H., Matsumura, T., Iwata, Y., Yamamoto, N., Yokoyama, Y., and Wakamatsu, Y. (2009) Cell growth-promoting activity of fluid from eye sacs of the bubble-eye goldfish (Carassius auratus). Zoolog. Sci.. 26(4):254-258
Shimizu, T., and Hibi, M. (2009) Formation and patterning of the forebrain and olfactory system by zinc-finger genes Fezf1 and Fezf2. Development, Growth & Differentiation. 51(3):221-231
Kim, H., Kim, S., Chung, A.Y., Bae, Y.K., Hibi, M., Lim, C.S., and Park, H.C. (2008) Notch-regulated perineurium development from zebrafish spinal cord. Neuroscience letters. 448(3):240-244
Asakawa, K., Suster, M.L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., and Kawakami, K. (2008) Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish. Proc. Natl. Acad. Sci. USA. 105(4):1255-1260
Katsuyama, Y., Oomiya, Y., Dekimoto, H., Motooka, E., Takano, A., Kikkawa, S., Hibi, M., and Terashima, T. (2007) Expression of zebrafish ROR alpha gene in cerebellar-like structures. Developmental dynamics : an official publication of the American Association of Anatomists. 236(9):2694-2701
Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., and Yamasu, K. (2007) Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal. Developmental dynamics : an official publication of the American Association of Anatomists. 236(2):564-571
Hashimoto, H., Uji, S., Kurokawa, T., Washio, Y., and Suzuki, T. (2007) Flounder and fugu have a single lefty gene that covers the functions of lefty1 and lefty2 of zebrafish during L-R patterning. Gene. 387(1-2):126-132
Shimizu, T., Bae, Y.K., and Hibi, M. (2006) Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development (Cambridge, England). 133(23):4709-4719
Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M. (2006) Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development (Cambridge, England). 133(8):1433-1443
Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y.K., Hashimoto, H., and Hibi, M. (2006) Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Nat. Cell Biol.. 8(4):329-340
Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.K., Nojima, H., and Hibi, M. (2005) E-cadherin is required for gastrulation cell movements in zebrafish. Mechanisms of Development. 122(6):747-763
Suzuki, T., Takagi, Y., Osanai, H., Li, L., Takeuchi, M., Katoh, Y., Kobayashi, M., and Yamamoto, M. (2005) Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish. The Biochemical journal. 388(Pt 1):65-73
Bae, Y.K., Shimizu, T., and Hibi, M. (2005) Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Development (Cambridge, England). 132(6):1375-1385
Shimizu, T., Bae, Y.K., Muraoka, O., and Hibi, M. (2005) Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Developmental Biology. 279(1):125-141
Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., and Aizawa, S. (2005) Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Cell. 120(2):223-35
Bae, Y.K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M. (2004) Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene Expression Patterns. 4(4):481-486
Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T., and Hibi, M. (2004) Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons. Developmental dynamics : an official publication of the American Association of Anatomists. 230(3):546-556
Hashimoto, H., Rebagliati, M., Ahmad, N., Muraoka, O., Kurokawa, T., Hibi, M., and Suzuki, T. (2004) The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development (Cambridge, England). 131(8):1741-1753
Nojima, H., Shimizu, T., Kim, C.H., Yabe, T., Bae, Y.K., Muraoka, O., Hirata, T., Chitnis, A., Hirano, T., and Hibi, M. (2004) Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. Mechanisms of Development. 121(4):371-386
Yabe, T., Shimizu, T., Muraoka, O., Bae, Y.-K., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., and Hibi, M. (2003) Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development (Cambridge, England). 130(12):2705-2716
Bae, Y.K., Shimizu, T., Yabe, T., Kim, C.H., Hirata, T., Nojima, H., Muraoka, O., Hirano, T., and Hibi, M. (2003) A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish. Development (Cambridge, England). 130(9):1853-1865
Levkowitz, G., Zeller, J., Sirotkin, H.I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A. (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nature Neuroscience. 6(1):28-33
Shimizu, T., Yamanaka, Y., Nojima, H., Yabe, T., Hibi, M., and Hirano, T. (2002) A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Mechanisms of Development. 118(1-2):125-38
Suzuki, T., Kurokawa, T., Hashimoto, H., and Sugiyama, M. (2002) cDNA sequence and tissue expression of Fugu rubripes prion protein-like: a candidate for the teleost orthologue of tetrapod PrPs. Biochemical and Biophysical Research Communications. 294(4):912-917
Yamashita, S., Miyagi, C., Carmany-Rampey, A., Shimizu, T., Fujii, R., Schier, A.F., and Hirano, T. (2002) Stat3 controls cell movements during zebrafish gastrulation. Developmental Cell. 2(3):363-375
Hibi, M., Hirano, T., and Dawid, I.B. (2002) Organizer formation and function. Results Probl. Cell Diff.. 40:48-71
Ryu, S.-L., Fujii, R., Yamanaka, Y., Shimizu, T., Yabe, T., Hirata, T., Hibi, M., and Hirano, T. (2001) Regulation of dharma/bozozok by the Wnt Pathway. Developmental Biology. 231(2):397-409
Muraoka, O., Ichikawa, H., Shi, H., Okumura, S., Taira, E., Higuchi, H., Hirano, T., Hibi, M., and Miki, N. (2000) Kheper, a Novel ZFH/δEF1 Family Member, Regulates the Development of the Neuroectoderm of Zebrafish (Danio rerio). Developmental Biology. 228(1):29-40
Park, H.-C., Kim, C.-H., Bae, Y.-K., Yee, S.-Y., Kim, S.-H., Hong, S.-K., Shin, J., Yoo, K.-W., Hibi, M., Hirano, T., Miki, N., Chitnis, A.B., and Huh, T.-L. (2000) Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons. Developmental Biology. 227(2):279-293
Fujii, R., Yamashita, S., Hibi, M., and Hirano, T. (2000) Asymmetric p38 activation in zebrafish: Its possible role in symmetric and synchronous cleavage. The Journal of cell biology. 150(6):1335-1347
Hashimoto, H., Yabe, T., Hirata, T., Shimizu, T., Bae, Y., Yamanaka, Y., Hirano, T., and Hibi, M. (2000) Expression of the zinc finger gene fez-like in zebrafish forebrain. Mechanisms of Development. 97(1-2):191-195
Hirata, T., Yamanaka, Y., Ryu, S.L., Shimizu, T., Yabe, T., Hibi, M., and Hirano, T. (2000) Novel mix-family homeobox genes in zebrafish and their differential regulation. Biochemical and Biophysical Research Communications. 271(3):603-609
Shimizu, T., Yamanaka, Y., Ryu, S., Hashimoto, H., Yabe, T., Hirata, T., Bae, Y., Hibi, M., and Hirano, T. (2000) Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. Mechanisms of Development. 91(1-2):293-303
Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T. (2000) Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Developmental Biology. 217(1):138-152
Fekany, K., Yamanaka, Y., Leung, T., Sirotkin, H.I., Topczewski, J., Gates, M.A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A.F., Driever, W., Hirano, T., Talbot, W.S., and Solnica-Krezel, L. (1999) The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development (Cambridge, England). 126:1427-1438
Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C.-H., Hibi, M., and Hirano, T. (1998) A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes and Development. 12:2345-2353
Kim, C.-H., Y.-K. Bae, Y. Yamanaka, S. Yamashita, T. Shimizu, R. Fujii, H.-C. Park, S.-Y. Yeo, T.-L. Huh, M. Hibi, and T. Hirano (1997) Overexpression of neurogenin induces ectopic expression of HuC in zebrafish. Neuroscience letters. 239:113-116