ZFIN Image: Mytlis et al., 2023, Fig. 1

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Figure Caption

Fig. 1 The Bouquet dynamic and MTOC machinery. Left: at the leptotene stage, the onset of meiotic prophase, specific meiotic proteins mediate the binding of telomeres (red) to Sun/KASH complexes (light and dark grey) on the nuclear envelope (NE). Microtubules (MT; magenta) grow from the centrosome MTOC (blue circles) and organize perinuclearly. Association of Sun/KASH with MT via dynein slides telomere-bound Sun/KASH complexes on the perinuclear MTs, moving them on the NE (grey arrows). Telomere movements (arrows) shuffle chromosomes and contribute to their homology searches. Right: telomere sliding on the MTs via the dynein (−) end motor ultimately pulls telomeres toward the centrosome side of the nucleus (grey arrows), clustering them while their chromosomes loop to the other side, and forming the bouquet configuration. Variations of this conserved machinery are discussed in the text.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Curr. Opin. Cell Biol.