ZFIN Image: Almeida et al., 2023, Figure 10.

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Figure Caption

Figure 10.

The process of sheath accumulation involves the repetitive ensheathment of axons and Rab5 promotes longitudinal sheath stabilization.

(A) A model depicting how the repetitive ensheathment of axons is occurring during the dynamic accumulation phase of the sheath formation process. Oligodendrocytes are green, axons are pink, and the nascent ensheathments are purple. (B) A model depicting that Rab5WT helps to promote the stabilization of nascent sheaths during the stabilization phase of the sheath formation process (left). The Rab5DN mutant instead results in fewer stabilized sheaths (right). Oligodendrocytes are green, axons are pink, nascent ensheathments are purple, and stabilized ensheathments are also green.

Acknowledgments

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