ZFIN Image: Lasbleiz et al., 2022, Fig. 7

Image

Figure Caption

Fig. 7 Increasing NRF2 levels reduced TDP43 toxicity. (A) RNA expression levels of NRF2 in larvae treated or not with sulforaphane. Data from n = 6 were presented as mean ± SEM. Statistical analysis was performed by the Student t-test (**p < 0.01; ***p < 0.001). (B) RNA expression levels of NRF2 targets: GCLC, GCLM, PRDX6 and PGD in larvae treated or not with sulforaphane. Data from n ≥ 5 were presented as mean ± SEM. Statistical analysis was performed by the Student t-test (**p < 0.01; ***p < 0.001). (C) Touch-escape response of control larvae or larvae expressing TDP43^G348C and treated or not with sulforaphane. Data from 25 were averaged and presented as mean ± SEM. Statistical analysis was performed by Tukey's test (*p < 0.05; ***p < 0.001). (D) Touch-escape response of control larvae or larvae expressing TDP43^G348C alone or with NRF2. Data from 25 larvae were averaged and presented as mean ± SEM. Statistical analysis was performed using ANOVA followed by Tukey's test (***p < 0.001).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Redox Biol.