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FIGURE 8
Schematic model of the study. The EWSR1 knockdown leads to the increased incidence of relocation of Aurora B from inner centromere to KPC (prometaphase and metaphase), of lagging chromosomes (anaphase), and of aneuploidy (after a single mitosis). Our data suggests that the EWSR1 prevents the induction of aneuploidy through interaction with Aurora B. Despite of the induction of chromosome mis-segregation in EWSR1 knockdown cells, the cells do not arrest at mitosis, and it is likely that the cells are overriding the error collection process.
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Full text @ Front Cell Dev Biol