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Fig. 1 CRK and CRKL are conserved across vertebrates, including Danio rerio. A and B, Multiple protein sequence alignments of CRK (A) and CRKL (B) performed using the Geneious R10 software. Alignment of Homo sapien, Mus musculus, Rattus norvegicus, Gallus gallus, Danio rerio, and Xenopus tropicalis amino acid sequences colored for similarity in greyscale. Domain structure is modeled above alignments (H. sapien amino acid numbers), and functional domains are color coded in both the diagram and highlighted above in the sequence alignment: SH2 domain (purple), N-SH3 domain (green), C-SH3 domain (orange). C, Table showing percent identity of protein sequences compared between each species. Grey boxes correspond to CRK percent identity and white boxes correspond to CRKL. D, Comparison of H. sapien and D. rerio percent identical amino acids of each functional domain. Grey boxes correspond to CRK percent identity and white boxes correspond to CRKL