Figure 2—figure supplement 2.

(A) Schematic representation of the PPR motifs and sequence homology domain structure of zebrafish Lrpprc. The homology domains are predicted by comparing the zebrafish Lrpprc sequence against multiple databases. The structural analysis predicted that in GBT0235 mutants, truncated Lrpprc had the insertion of mRFP towards the end of PPR motif 17. (B) Structure-based prediction of PPR motifs. PPR sequences and comprehensive residues are represented on the left. The cyan color highlighted amino acids specify the RNA binding of PPR motifs. The predicted target ribonucleotides for each motif are presented on the right. The targets with and without the star marks are high confidence and speculative predictions, respectively. We put the corresponding question mark sign where the prediction for the PPR motif was not sure. The italicized motif was highly degenerate and may consist of a pair of PPRs.