ZFIN Image: Bhandiwad et al., 2022, Fig. 8.

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Figure Caption

Fig. 8.

Circuit model for tonic immobility.

(A) Defense cascade behaviors represented in terms of relative movement with respect to perceived threat. (B) Repeated, inescapable stimuli activate peripheral auditory (SAG) and lateral line ganglia, which then excite the granule cells of the cerebellum (green lines). During stimulus presentation, the cerebellum sends inhibitory projections to the prepontine neurons (vPPNs) and eurydendroid cells (ECs), which may project to vPPNs (dashed lines). Following sustained vibratory stimulation, cerebellar inhibition ceases and leads to activation of the vPPNs. Bilateral activation of the vPPNs disrupts RoL1 neuron activity, leading to suppressed turning behavior and immobility.

Acknowledgments

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