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Fig. 9
Fig. 9. Model showing the differential activities of the S protein of SARS-CoV-2 VOCs.S1 proteins promote neutrophil and macrophage recruitment, local and systemic hyperinflammation, emergency myelopoiesis, and hemorrhages. Inhibition of Ace2 exacerbates all these effects, while inhibition of the inflammasome with the caspase-1 inhibitor VX-765 or Ang (1-7) treatment alleviates them. S1γ was more proinflammatory, while S1δ was less proinflammatory than S1WT, and S1β promoted delayed and long-lasting inflammation.
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