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Fig. 5
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Figure Caption
Fig. 5. TNF-induced glutaminolysis increases succinate levels in mycobacterium-infected macrophages in a RIP3- and PGAM5-dependent manner.
(A and B) Quantification of succinate in zebrafish larvae 1 day after infection with Mm or mock-injected, that are wild-type or TNFhi treated with GPNA, BPTES, or vehicle (A) and TNFhi, TNFhi RIP3 morphants, or TNFhi PGAM5 morphants (B). Each point represents the mean of four independent experiments in (A) and two independent experiments in (B). Vertical bars denote pooled SD. ***P < 0.001, ****P < 0.0001 (one-way ANOVA with Tukey’s post-test); ns, not significant.
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