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Fig. 6
Figure 6. Gene set enrichment analysis of hallmark gene sets epithelial mesenchymal transition and inflammatory response. (A) GSEA summary plot of epithelial mesenchymal transition gene set comparing xmrk intestine to wt intestine. The gene set was highly enriched and upregulated: normalized enrichment score (NES) = 2.80, FDR q─value < 0.0001. (B) Heatmap of leading edge subset genes within the epithelial mesenchymal transition gene set (red: high expression; blue: low expression). (C) GSEA summary plot of inflammatory response gene set comparing xmrk intestine to wt intestine. The gene set was enriched and upregulated: NES = 1.63, FDR q─value = 0.0464. (D) Heatmap of leading edge subset genes within the inflammatory response gene set (red: high expression; blue: low expression).
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