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Figure 3

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ZDB-IMAGE-220104-102
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Figures for Gharbi et al., 2021
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Figure Caption

Figure 3 Ultrastructural changes in the retinal pigment epithelium induced by the loss of DJ-1 are inhibited by introducing DJ-1 in Müller cells. Electron micrographs of photoreceptors (pr) and retinal pigment epithelium (RPE) of wild-type (A), DJ-1 knockout (B), Müller-expressed DJ-1 (C) and Müller-expressed DJ-1c106a mutant (D) retinas from 4-month-old adult zebrafish. DJ-1-deficient retinas displayed a high degree of vacuolization (v), in addition to large electron-dense structures (*) in the RPE. The large electron-dense structures contained remnants of membranous/filamentous structures. Transgenic retinas expressing Müller-selective DJ-1c106a mutant displayed similar morphology as DJ-1 knockouts. The ultrastructural changes induced by DJ-1 loss were prevented by Müller cell selective expression of wild type DJ-1. Different stages of phagosomes containing segment filaments can be seen in wild-type and Müller_DJ-1 retinas (marked with arrowhead and p). Bar, 1 µm.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)