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Figure 1
The BH3-only proapoptotic gene Bad can regulate brain development at 24 hpf. (A) Bad knockdown (lane 2 for 0.2 mM) shown by Western blot analysis and compared to the uninjected group (lane 1) and the normal control Bad-M5 group (lane 3). The protein expression levels were quantified by a Personal Densitometer (Molecular Dynamics). (B) Dissection and observation of brain development in loss-of-Bad-mediated PCD embryos at 24 hpf. HE staining showing hindbrain development in the Bad-M5 group in panel (Ba) and the Bad-Mo group in panel (Bb) at 24 hpf, as indicated by red arrows.
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