ZFIN Image: Gourain et al., 2021, FIGURE 4

Image

Figure Caption

FIGURE 4

Sterol Regulatory Element (SRE) motif analysis. (A) Two mammalian SRE motifs were retrieved from the literature (left and middle panels). From the mapping of these two consensus sequences one SRE motif derived in the zebrafish genome (right panel). (B) The SRE motifs were mapped in the promoter of genes involved in cholesterol metabolism. The promoter sequence was defined from 1 kb upstream of the transcription start site and the SRE motif were mapped in both forward (+) and reverse (–) strands. (C) Genes harboring a SRE motif in their 1-kb promoter (underlined) were identified in the cholesterol synthesis pathway, including genes coding for two upstream regulators (srebf2 and insig1). For further details see also legend to Figure 3A.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.