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Figure 2—figure supplement 2.

ID: ZDB-IMAGE-210319-12
Source: Figures for Vinayagam et al., 2020

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Figure Caption

Figure 2—figure supplement 2. Cryo-EM map of TRPC4 in complex with the inhibitor GFB-9289 and GFB-8749.

(A) Side and top view of the cryo-EM map of GFB-9289 inhibitor-bound TRPC4, with each subunit colored differently. Positions of the transmembrane domain (TMD) and intracellular cytosolic domain (ICD) are indicated. (B) Location of non-protein densities relative to the atomic model of TRPC4, which is shown in transparent ribbon representation in the side- and top view. Densities corresponding to lipids are depicted in red, GFB-9289 density is shown in blue. (C) Same as in (A), but for the cryo-EM map of GFB-8749 inhibitor-bound TRPC4. (D) Same as in (B), except the density for GFB-8749 is shown in green.

Acknowledgments

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